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An evolutionary explanation for the perturbation of the dynamics of metastatic tumors induced by surgery and acute inflammation.

Carmona Bayonas A - Cancers (Basel) (2011)

Bottom Line: The postsurgical patterns of progression include unexpected features such as distant interactions and variable rhythms.The paper proposes that distant interactions are an extension of the ecological events at the local level.This notion explains the evolutionary basis for tumor dormancy, and warns against the teleological view of tumorigenesis as a process directed towards the maximization of a concrete trait such as aggressiveness.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology and Medical Oncology, Hospital Morales Meseguer, Murcia, Spain. alberto.carmonabayonas@gmail.com.

ABSTRACT
Surgery has contributed to unveil a tumor behavior that is difficult to reconcile with the models of tumorigenesis based on gradualism. The postsurgical patterns of progression include unexpected features such as distant interactions and variable rhythms. The underlying evidence can be summarized as follows: (1) the resection of the primary tumor is able to accelerate the evolution of micrometastasis in early stages, and (2) the outcome is transiently opposed in advanced tumors. The objective of this paper is to give some insight into tumorigenesis and surgery-related effects, by applying the concepts of the evolutionary theory in those tumor behaviors that gompertzian and tissular-centered models are unable to explain. According to this view, tumors are the consequence of natural selection operating at the somatic level, which is the basic mechanism of tumorigenesis, notwithstanding the complementary role of the intrinsic constrictions of complex networks. A tumor is a complicated phenomenon that entails growth, evolution and development simultaneously. So, an evo-devo perspective can explain how and why tumor subclones are able to translate competition from a metabolic level into neoangiogenesis and the immune response. The paper proposes that distant interactions are an extension of the ecological events at the local level. This notion explains the evolutionary basis for tumor dormancy, and warns against the teleological view of tumorigenesis as a process directed towards the maximization of a concrete trait such as aggressiveness.

No MeSH data available.


Related in: MedlinePlus

Environmental pressures contribute to make the choice between neoangiogenesis and EMT. The balance between both processes is a suitable target for natural selection, operating at the somatic level.
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f3-cancers-03-00945: Environmental pressures contribute to make the choice between neoangiogenesis and EMT. The balance between both processes is a suitable target for natural selection, operating at the somatic level.

Mentions: First, the transcription factors involved in EMT, such as slug, snail and SIP1 are negative regulators of proliferation via the downregulation of cyclin D1 expression, and other inducers of the cell cycle [43-45]. It actually makes sense because the radical cytoskeletal rearrangement that is required during cell movement is not really compatible with mitosis. Therefore, the cells undergoing EMT lose their proliferative capacity, and thereby the balance between EMT and angiogenesis can be a suitable target for natural selection (Figure 3).


An evolutionary explanation for the perturbation of the dynamics of metastatic tumors induced by surgery and acute inflammation.

Carmona Bayonas A - Cancers (Basel) (2011)

Environmental pressures contribute to make the choice between neoangiogenesis and EMT. The balance between both processes is a suitable target for natural selection, operating at the somatic level.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3756398&req=5

f3-cancers-03-00945: Environmental pressures contribute to make the choice between neoangiogenesis and EMT. The balance between both processes is a suitable target for natural selection, operating at the somatic level.
Mentions: First, the transcription factors involved in EMT, such as slug, snail and SIP1 are negative regulators of proliferation via the downregulation of cyclin D1 expression, and other inducers of the cell cycle [43-45]. It actually makes sense because the radical cytoskeletal rearrangement that is required during cell movement is not really compatible with mitosis. Therefore, the cells undergoing EMT lose their proliferative capacity, and thereby the balance between EMT and angiogenesis can be a suitable target for natural selection (Figure 3).

Bottom Line: The postsurgical patterns of progression include unexpected features such as distant interactions and variable rhythms.The paper proposes that distant interactions are an extension of the ecological events at the local level.This notion explains the evolutionary basis for tumor dormancy, and warns against the teleological view of tumorigenesis as a process directed towards the maximization of a concrete trait such as aggressiveness.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology and Medical Oncology, Hospital Morales Meseguer, Murcia, Spain. alberto.carmonabayonas@gmail.com.

ABSTRACT
Surgery has contributed to unveil a tumor behavior that is difficult to reconcile with the models of tumorigenesis based on gradualism. The postsurgical patterns of progression include unexpected features such as distant interactions and variable rhythms. The underlying evidence can be summarized as follows: (1) the resection of the primary tumor is able to accelerate the evolution of micrometastasis in early stages, and (2) the outcome is transiently opposed in advanced tumors. The objective of this paper is to give some insight into tumorigenesis and surgery-related effects, by applying the concepts of the evolutionary theory in those tumor behaviors that gompertzian and tissular-centered models are unable to explain. According to this view, tumors are the consequence of natural selection operating at the somatic level, which is the basic mechanism of tumorigenesis, notwithstanding the complementary role of the intrinsic constrictions of complex networks. A tumor is a complicated phenomenon that entails growth, evolution and development simultaneously. So, an evo-devo perspective can explain how and why tumor subclones are able to translate competition from a metabolic level into neoangiogenesis and the immune response. The paper proposes that distant interactions are an extension of the ecological events at the local level. This notion explains the evolutionary basis for tumor dormancy, and warns against the teleological view of tumorigenesis as a process directed towards the maximization of a concrete trait such as aggressiveness.

No MeSH data available.


Related in: MedlinePlus