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Treatment resistance mechanisms of malignant glioma tumor stem cells.

Schmalz PG, Shen MJ, Park JK - Cancers (Basel) (2011)

Bottom Line: Recent evidence suggests that a minor subpopulation of cells with stem cell properties reside within these tumors.These tumor stem cells are more resistant to radiation and chemotherapies than their counterpart differentiated tumor cells and may underlie the persistence and recurrence of tumors following treatment.The various mechanisms by which tumor stem cells avoid or repair the damaging effects of cancer therapies are discussed.

View Article: PubMed Central - PubMed

Affiliation: Surgical and Molecular Neuro-Oncology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. parkjk@ninds.nih.gov.

ABSTRACT
Malignant gliomas are highly lethal because of their resistance to conventional treatments. Recent evidence suggests that a minor subpopulation of cells with stem cell properties reside within these tumors. These tumor stem cells are more resistant to radiation and chemotherapies than their counterpart differentiated tumor cells and may underlie the persistence and recurrence of tumors following treatment. The various mechanisms by which tumor stem cells avoid or repair the damaging effects of cancer therapies are discussed.

No MeSH data available.


Related in: MedlinePlus

Mediators of TSC treatment resistance. Depicted are the various treatment resistance mechanisms and pathways differentially expressed or regulated in TSC versus their differentiated cell counterparts. Blocked red lines indicate ways to inhibit or block these mediators.
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f1-cancers-03-00621: Mediators of TSC treatment resistance. Depicted are the various treatment resistance mechanisms and pathways differentially expressed or regulated in TSC versus their differentiated cell counterparts. Blocked red lines indicate ways to inhibit or block these mediators.

Mentions: The preceding functional properties support the hypothesis that TSC are the cells responsible for the initiation and propagation of patient tumors. An extension of this hypothesis is that the overall treatment resistance of GBM tumors is due in large part to the treatment resistance of TSC in particular. Diverse mechanisms of radio- and chemo- therapeutic resistance have been demonstrated in the TSC population including increased expression of drug efflux transporters, a more robust DNA damage response, reduced sensitivity to apoptotic signals, increased expression of growth factors and dysregulation of transcription (Figure 1). This review will summarize recent research findings on these resistance mechanisms and discuss the various strategies used to circumvent these mechanisms.


Treatment resistance mechanisms of malignant glioma tumor stem cells.

Schmalz PG, Shen MJ, Park JK - Cancers (Basel) (2011)

Mediators of TSC treatment resistance. Depicted are the various treatment resistance mechanisms and pathways differentially expressed or regulated in TSC versus their differentiated cell counterparts. Blocked red lines indicate ways to inhibit or block these mediators.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3756380&req=5

f1-cancers-03-00621: Mediators of TSC treatment resistance. Depicted are the various treatment resistance mechanisms and pathways differentially expressed or regulated in TSC versus their differentiated cell counterparts. Blocked red lines indicate ways to inhibit or block these mediators.
Mentions: The preceding functional properties support the hypothesis that TSC are the cells responsible for the initiation and propagation of patient tumors. An extension of this hypothesis is that the overall treatment resistance of GBM tumors is due in large part to the treatment resistance of TSC in particular. Diverse mechanisms of radio- and chemo- therapeutic resistance have been demonstrated in the TSC population including increased expression of drug efflux transporters, a more robust DNA damage response, reduced sensitivity to apoptotic signals, increased expression of growth factors and dysregulation of transcription (Figure 1). This review will summarize recent research findings on these resistance mechanisms and discuss the various strategies used to circumvent these mechanisms.

Bottom Line: Recent evidence suggests that a minor subpopulation of cells with stem cell properties reside within these tumors.These tumor stem cells are more resistant to radiation and chemotherapies than their counterpart differentiated tumor cells and may underlie the persistence and recurrence of tumors following treatment.The various mechanisms by which tumor stem cells avoid or repair the damaging effects of cancer therapies are discussed.

View Article: PubMed Central - PubMed

Affiliation: Surgical and Molecular Neuro-Oncology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. parkjk@ninds.nih.gov.

ABSTRACT
Malignant gliomas are highly lethal because of their resistance to conventional treatments. Recent evidence suggests that a minor subpopulation of cells with stem cell properties reside within these tumors. These tumor stem cells are more resistant to radiation and chemotherapies than their counterpart differentiated tumor cells and may underlie the persistence and recurrence of tumors following treatment. The various mechanisms by which tumor stem cells avoid or repair the damaging effects of cancer therapies are discussed.

No MeSH data available.


Related in: MedlinePlus