Schistosoma mansoni experimental infection in Mus spretus (SPRET/EiJ strain) mice.
Bottom Line: Mus musculus (CD1 strain) mice.The parasitological data suggests that SPRET/EiJ mice tolerate higher parasite loads compared to CD1 strain.In addition, hematological parameters measured in Mus spretus group showed a significant increase in granulocytes population in early stages of infection compared to the CD1 cohort.
Affiliation: Laboratorio de Inmunología y Parasitología Molecular, CIETUS, Facultad de Farmacia, Universidad de Salamanca, 37008 Salamanca, Spain - Instituto de Investigaciones Biomédicas de Salamanca (IBSAL), Salamanca, Spain.Show MeSH
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Mentions: In this study, we also analyzed the immunological and hematological profiles presented during S. mansoni infection in SPRET/EiJ and CD1 mice. The variables studied were white blood cell counts, and IgG1 and IgG2a isotype-specific subclasses. Regarding the humoral response, our results show a typical progressive enhancement on antibodies levels against the SWAP during S. mansoni experimental infection in both subtypes of immunoglobulin analyzed. Specifically, SPRET/EiJ mice showed an increase of IgG2a levels compared to CD1 at 9 weeks post-infection in both sexes (p < 0.05) (Figure 1A). On the other hand, female CD1 mice showed significant higher IgG1 levels at 3 and 6 weeks after infection compared with female SPRET/EiJ mice (p < 0.05). Furthermore, significant higher IgG1 levels were also found in CD1 male mice compared to their SPRET/EiJ counterparts at 6 weeks after infection (p < 0.05) (Figure 1B). These results suggested that CD1 mice would present a stronger Th2 immune response against S. mansoni compared to SPRET/EiJ mice.Figure 1.
Affiliation: Laboratorio de Inmunología y Parasitología Molecular, CIETUS, Facultad de Farmacia, Universidad de Salamanca, 37008 Salamanca, Spain - Instituto de Investigaciones Biomédicas de Salamanca (IBSAL), Salamanca, Spain.