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Sterol Ring System Oxidation Pattern in Marine Sponges

View Article: PubMed Central

ABSTRACT

The marine sponges (Porifera) are a unique group of sedentary organisms from which several novel natural products are reported, many of which have useful biological activities. In producing unusual sterols, they occupy a preeminent position among the various groups of organisms. The polar sterols of sponges reported as at the end of the year 2002 number about 250; their ring structure changing a hundred times. The oxidation pattern in the sterol ring system, from the point of view of biogenesis seems to be mainly of four types. Each sponge species is able to produce sterols fitting into one of the four main biogenetic pathways viz., (i) 3β-hydroxy-Δ5-sterol pathway, (ii) 3β-hydroxy-Δ7-sterol pathway, (iii) 3β-hydroxy-Δ5,7-sterol pathway, and (iv) 3α-hydroxy sterol pathway.

No MeSH data available.


3α-oxysteroids: Δ5 origin; [ ] : not isolated, S = side chain
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Related In: Results  -  Collection


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f12-marinedrugs-03-00084: 3α-oxysteroids: Δ5 origin; [ ] : not isolated, S = side chain

Mentions: The polar sterols of sponges, particularly the sulfate esters (Schemes 12–14) have interesting and useful biological activities that make them targets of biological evaluation and synthesis.


Sterol Ring System Oxidation Pattern in Marine Sponges
3α-oxysteroids: Δ5 origin; [ ] : not isolated, S = side chain
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3756323&req=5

f12-marinedrugs-03-00084: 3α-oxysteroids: Δ5 origin; [ ] : not isolated, S = side chain
Mentions: The polar sterols of sponges, particularly the sulfate esters (Schemes 12–14) have interesting and useful biological activities that make them targets of biological evaluation and synthesis.

View Article: PubMed Central

ABSTRACT

The marine sponges (Porifera) are a unique group of sedentary organisms from which several novel natural products are reported, many of which have useful biological activities. In producing unusual sterols, they occupy a preeminent position among the various groups of organisms. The polar sterols of sponges reported as at the end of the year 2002 number about 250; their ring structure changing a hundred times. The oxidation pattern in the sterol ring system, from the point of view of biogenesis seems to be mainly of four types. Each sponge species is able to produce sterols fitting into one of the four main biogenetic pathways viz., (i) 3β-hydroxy-Δ5-sterol pathway, (ii) 3β-hydroxy-Δ7-sterol pathway, (iii) 3β-hydroxy-Δ5,7-sterol pathway, and (iv) 3α-hydroxy sterol pathway.

No MeSH data available.