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The relation of onychomatricoma to onychodermis in the nail unit.

Lee DY - Ann Dermatol (2013)

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

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Recently, based on its histopathological and immunohistochemical features, the concept of epithelial onychogenic tumor with onychogenic mesenchyme is being suggested for this peculiar mixed tumor... Based on this finding, we proposed new terminology onychodermis for specialized mesenchyme because it is histologically and immunohistochemically distinct from the dermis of other parts of the nail unit... This study evaluates the relation of onychomatricoma to onychodermis in the nail unit we performed CD10 immunohistochemistry in one case of onychomatricoma sample (a kind gift from Dr Robert Baran and Dr Josette André)... As reported previously, CD10 is strongly expressed in the onychodermis below the nail matrix and nail bed within normal nail unit (data not shown)... Onychomatricoma is a subungual tumor which consists of epithelial onychogenic tumor with onychogenic mesenchyme... According to a previous study using organotypic cultures, the fibroblasts around the nail matrix induced hard keratin expressions in the non-nail-matrix keratinocytes through epithelial-mesenchymal interactions... Thus, the onychodermis containing onychofibroblasts may play an important role in nail formation through epithelial-mesenchymal interactions... Epithelial lesion in onychomatricoma might be induced by mesenchymal tumor occurring in the onychodermis... To deduce, the onychodermis might be involved in the histogenesis of the onychomatricoma... In conclusion, onychomatricoma seems to be closely related to the onychodermis... It might be a derivative from onychoderms.

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Immunohistochemical staining of CD10 in onychomatricoma. CD10 was diffusely expressed in the stroma of onychomatricoma. (A) Low-power view (×40), (B) highpower view (×200).
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Figure 1: Immunohistochemical staining of CD10 in onychomatricoma. CD10 was diffusely expressed in the stroma of onychomatricoma. (A) Low-power view (×40), (B) highpower view (×200).

Mentions: As reported previously, CD10 is strongly expressed in the onychodermis below the nail matrix and nail bed within normal nail unit (data not shown). In the onychomatricoma case, CD10 is being expressed diffusely in the stoma (Fig. 1).


The relation of onychomatricoma to onychodermis in the nail unit.

Lee DY - Ann Dermatol (2013)

Immunohistochemical staining of CD10 in onychomatricoma. CD10 was diffusely expressed in the stroma of onychomatricoma. (A) Low-power view (×40), (B) highpower view (×200).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3756218&req=5

Figure 1: Immunohistochemical staining of CD10 in onychomatricoma. CD10 was diffusely expressed in the stroma of onychomatricoma. (A) Low-power view (×40), (B) highpower view (×200).
Mentions: As reported previously, CD10 is strongly expressed in the onychodermis below the nail matrix and nail bed within normal nail unit (data not shown). In the onychomatricoma case, CD10 is being expressed diffusely in the stoma (Fig. 1).

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Recently, based on its histopathological and immunohistochemical features, the concept of epithelial onychogenic tumor with onychogenic mesenchyme is being suggested for this peculiar mixed tumor... Based on this finding, we proposed new terminology onychodermis for specialized mesenchyme because it is histologically and immunohistochemically distinct from the dermis of other parts of the nail unit... This study evaluates the relation of onychomatricoma to onychodermis in the nail unit we performed CD10 immunohistochemistry in one case of onychomatricoma sample (a kind gift from Dr Robert Baran and Dr Josette André)... As reported previously, CD10 is strongly expressed in the onychodermis below the nail matrix and nail bed within normal nail unit (data not shown)... Onychomatricoma is a subungual tumor which consists of epithelial onychogenic tumor with onychogenic mesenchyme... According to a previous study using organotypic cultures, the fibroblasts around the nail matrix induced hard keratin expressions in the non-nail-matrix keratinocytes through epithelial-mesenchymal interactions... Thus, the onychodermis containing onychofibroblasts may play an important role in nail formation through epithelial-mesenchymal interactions... Epithelial lesion in onychomatricoma might be induced by mesenchymal tumor occurring in the onychodermis... To deduce, the onychodermis might be involved in the histogenesis of the onychomatricoma... In conclusion, onychomatricoma seems to be closely related to the onychodermis... It might be a derivative from onychoderms.

No MeSH data available.