Limits...
Plasmocytoma-induced intertriginous amyloid purpura.

Schreml S, Schroeder J, Siegmund H, Eder F, Babilas P, Landthaler M, Karrer S - Ann Dermatol (2013)

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, University Medical Center Regensburg, Regensburg, Germany.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Eight months before, diagnosis of immunoglobulin A-light-chain plasmocytoma (type lambda) had been made... However, the etiology of skin lesions was still unclear... She did not take any anticoagulants... An inframammary skin biopsy showed subepidermal amorphous eosinophilic material (Fig. 1C, D) and erythrocyte extravasation... In-situ-hybridization revealed lambda light-chains (Fig. 1F, no kappa light-chains were found: see Fig. 1E); hence, systemic immunoglobulin light-chain amyloidosis was suspected... Typically, amyloid purpura occurs above the nipple-line, mostly on the head and neck, and particularly on the eyelids,... Among the suspected reasons for dermatorrhagia are that factor X is decreased by binding to amyloid fibrils, and that amyloid deposits in blood vessel walls increase vessel fragility... As purpura may be among the first signs of systemic amyloidoses, it is of utmost importance for dermatologists to keep this sign in mind... Furthermore, it is crucial to treat the underlying cause (e.g., multiple myeloma, plasmocytoma, renal insufficiency with hemodialysis)... However, there are also a couple of hereditary systemic amyloidoses with cutaneous involvement, e.g., Meretoja's syndrome (i.e. gelsolin amyloidosis)... Future treatments with siRNAs or antiamyloid antibodies are in the pipeline,, and we will see which ones make their way from bench to bedside.

No MeSH data available.


Related in: MedlinePlus

Plasmocytoma-induced intertriginous amyloid purpura. Inframammary (A) and inguinal (B) purpura. (C, D) Subepidermal amorphous eosinophilic material (H&E, ×40). In-situ hybridization for kappa (E) and lamba (F) light chains (×40). Only lambda light-chains were found. (G) Electron microscopy revealed amyloid (left part of the image) next to collagen fibers (right part of the image) (in situ hybridization for immunoglobulin light chains, ×10,000). (H) Amyloid fibrils (in situ hybridization for immunoglobulin light chains, ×20,000).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3756216&req=5

Figure 1: Plasmocytoma-induced intertriginous amyloid purpura. Inframammary (A) and inguinal (B) purpura. (C, D) Subepidermal amorphous eosinophilic material (H&E, ×40). In-situ hybridization for kappa (E) and lamba (F) light chains (×40). Only lambda light-chains were found. (G) Electron microscopy revealed amyloid (left part of the image) next to collagen fibers (right part of the image) (in situ hybridization for immunoglobulin light chains, ×10,000). (H) Amyloid fibrils (in situ hybridization for immunoglobulin light chains, ×20,000).

Mentions: A 58-year-old woman presented with inframammary and inguinal purpuric, non-blanching lesions (Fig. 1A, B).


Plasmocytoma-induced intertriginous amyloid purpura.

Schreml S, Schroeder J, Siegmund H, Eder F, Babilas P, Landthaler M, Karrer S - Ann Dermatol (2013)

Plasmocytoma-induced intertriginous amyloid purpura. Inframammary (A) and inguinal (B) purpura. (C, D) Subepidermal amorphous eosinophilic material (H&E, ×40). In-situ hybridization for kappa (E) and lamba (F) light chains (×40). Only lambda light-chains were found. (G) Electron microscopy revealed amyloid (left part of the image) next to collagen fibers (right part of the image) (in situ hybridization for immunoglobulin light chains, ×10,000). (H) Amyloid fibrils (in situ hybridization for immunoglobulin light chains, ×20,000).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3756216&req=5

Figure 1: Plasmocytoma-induced intertriginous amyloid purpura. Inframammary (A) and inguinal (B) purpura. (C, D) Subepidermal amorphous eosinophilic material (H&E, ×40). In-situ hybridization for kappa (E) and lamba (F) light chains (×40). Only lambda light-chains were found. (G) Electron microscopy revealed amyloid (left part of the image) next to collagen fibers (right part of the image) (in situ hybridization for immunoglobulin light chains, ×10,000). (H) Amyloid fibrils (in situ hybridization for immunoglobulin light chains, ×20,000).
Mentions: A 58-year-old woman presented with inframammary and inguinal purpuric, non-blanching lesions (Fig. 1A, B).

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, University Medical Center Regensburg, Regensburg, Germany.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Eight months before, diagnosis of immunoglobulin A-light-chain plasmocytoma (type lambda) had been made... However, the etiology of skin lesions was still unclear... She did not take any anticoagulants... An inframammary skin biopsy showed subepidermal amorphous eosinophilic material (Fig. 1C, D) and erythrocyte extravasation... In-situ-hybridization revealed lambda light-chains (Fig. 1F, no kappa light-chains were found: see Fig. 1E); hence, systemic immunoglobulin light-chain amyloidosis was suspected... Typically, amyloid purpura occurs above the nipple-line, mostly on the head and neck, and particularly on the eyelids,... Among the suspected reasons for dermatorrhagia are that factor X is decreased by binding to amyloid fibrils, and that amyloid deposits in blood vessel walls increase vessel fragility... As purpura may be among the first signs of systemic amyloidoses, it is of utmost importance for dermatologists to keep this sign in mind... Furthermore, it is crucial to treat the underlying cause (e.g., multiple myeloma, plasmocytoma, renal insufficiency with hemodialysis)... However, there are also a couple of hereditary systemic amyloidoses with cutaneous involvement, e.g., Meretoja's syndrome (i.e. gelsolin amyloidosis)... Future treatments with siRNAs or antiamyloid antibodies are in the pipeline,, and we will see which ones make their way from bench to bedside.

No MeSH data available.


Related in: MedlinePlus