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Dose-dependent effects of evening primrose oil in children and adolescents with atopic dermatitis.

Chung BY, Kim JH, Cho SI, Ahn IS, Kim HO, Park CW, Lee CH - Ann Dermatol (2013)

Bottom Line: The aim of this study is to investigate the dose-response treatment effects of evening primrose oil on clinical symptoms of AD and serum concentrations of polyunsaturated fatty acids.The serum fatty acid levels C18 : 3n and C20 : 4 were higher in the 320 mg group than in the 160 mg group, with statistical significance.There were no side effects seen in either group during the study in the 2 groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea.

ABSTRACT

Background: Previous clinical trials with evening primrose oil in atopic dermatitis (AD) treatment have shown different results. In addition, the optimal dose and duration of treatment with evening primrose oil have not yet been determined.

Objective: The aim of this study is to investigate the dose-response treatment effects of evening primrose oil on clinical symptoms of AD and serum concentrations of polyunsaturated fatty acids.

Methods: Forty AD patients were enrolled for the study and randomly divided into 2 groups: those who received evening primrose oil 160 mg daily for 8 weeks and those who received 320 mg of evening primrose oil twice daily for 8 weeks. We evaluated the Eczema Area Severity Index (EASI) scores of all AD patients at weeks 0, 2, 4 and 8. In addition, we measured the levels of serum fatty acids, including C16 : 0 (palmitic), C18 : 2n (linoleic), C18 : 3n (linolenic) and C20 : 4 (arachidonic acid) using gas chromatography.

Results: The serum fatty acid levels C18 : 3n and C20 : 4 were higher in the 320 mg group than in the 160 mg group, with statistical significance. After evening primrose oil treatment, EASI scores were reduced in the 2 groups. The improvement in EASI scores was greater in the 320 mg group than in the 160 mg group. There were no side effects seen in either group during the study in the 2 groups.

Conclusion: The results of this study suggest that the 320 mg and 160 mg groups may be equally effective in treating AD patients and show dose-dependent effects on serum fatty acid levels and EASI scores.

No MeSH data available.


Related in: MedlinePlus

A 10-year-old boy with atopic dermatitis. (A) Clinical photograph taken at first visit showing scaly erythematous patches, small erythematous papules and excoriations on the neck. (B) Clinical photograph taken eight weeks after supplementation of gamma-linolenic acid 320 mg/d shows considerably improved skin lesions.
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Figure 2: A 10-year-old boy with atopic dermatitis. (A) Clinical photograph taken at first visit showing scaly erythematous patches, small erythematous papules and excoriations on the neck. (B) Clinical photograph taken eight weeks after supplementation of gamma-linolenic acid 320 mg/d shows considerably improved skin lesions.

Mentions: After GLA supplementation, AD patients showed clinical improvement (Fig. 2). In the 160 mg group, the mean EASI scores were 5.850±1.548, 5.350±1.367, 4.850±1.451 and 4.525±3.581 at weeks 0, 2, 4 and 8, respectively (Fig. 3). There were no significant differences in the EASI scores between the first and last measurements (p=0.55). In the 320 mg group, the mean EASI scores were 6.250±1.713, 5.450±1.512, 4.200±1.174 and 3.475±1.175 at weeks 0, 2, 4 and 8, respectively (Fig. 3). The differences in EASI scores between the first and final visit were statistically significant (p=0.000). The changes in EASI scores were greater in the 320 mg group than in the 160 mg group: in the 160 mg group, the mean EASI scores were 1.29 times lower at the last visit than at the first visit, whereas in the 320 mg group, they were 1.8 times lower.


Dose-dependent effects of evening primrose oil in children and adolescents with atopic dermatitis.

Chung BY, Kim JH, Cho SI, Ahn IS, Kim HO, Park CW, Lee CH - Ann Dermatol (2013)

A 10-year-old boy with atopic dermatitis. (A) Clinical photograph taken at first visit showing scaly erythematous patches, small erythematous papules and excoriations on the neck. (B) Clinical photograph taken eight weeks after supplementation of gamma-linolenic acid 320 mg/d shows considerably improved skin lesions.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3756191&req=5

Figure 2: A 10-year-old boy with atopic dermatitis. (A) Clinical photograph taken at first visit showing scaly erythematous patches, small erythematous papules and excoriations on the neck. (B) Clinical photograph taken eight weeks after supplementation of gamma-linolenic acid 320 mg/d shows considerably improved skin lesions.
Mentions: After GLA supplementation, AD patients showed clinical improvement (Fig. 2). In the 160 mg group, the mean EASI scores were 5.850±1.548, 5.350±1.367, 4.850±1.451 and 4.525±3.581 at weeks 0, 2, 4 and 8, respectively (Fig. 3). There were no significant differences in the EASI scores between the first and last measurements (p=0.55). In the 320 mg group, the mean EASI scores were 6.250±1.713, 5.450±1.512, 4.200±1.174 and 3.475±1.175 at weeks 0, 2, 4 and 8, respectively (Fig. 3). The differences in EASI scores between the first and final visit were statistically significant (p=0.000). The changes in EASI scores were greater in the 320 mg group than in the 160 mg group: in the 160 mg group, the mean EASI scores were 1.29 times lower at the last visit than at the first visit, whereas in the 320 mg group, they were 1.8 times lower.

Bottom Line: The aim of this study is to investigate the dose-response treatment effects of evening primrose oil on clinical symptoms of AD and serum concentrations of polyunsaturated fatty acids.The serum fatty acid levels C18 : 3n and C20 : 4 were higher in the 320 mg group than in the 160 mg group, with statistical significance.There were no side effects seen in either group during the study in the 2 groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea.

ABSTRACT

Background: Previous clinical trials with evening primrose oil in atopic dermatitis (AD) treatment have shown different results. In addition, the optimal dose and duration of treatment with evening primrose oil have not yet been determined.

Objective: The aim of this study is to investigate the dose-response treatment effects of evening primrose oil on clinical symptoms of AD and serum concentrations of polyunsaturated fatty acids.

Methods: Forty AD patients were enrolled for the study and randomly divided into 2 groups: those who received evening primrose oil 160 mg daily for 8 weeks and those who received 320 mg of evening primrose oil twice daily for 8 weeks. We evaluated the Eczema Area Severity Index (EASI) scores of all AD patients at weeks 0, 2, 4 and 8. In addition, we measured the levels of serum fatty acids, including C16 : 0 (palmitic), C18 : 2n (linoleic), C18 : 3n (linolenic) and C20 : 4 (arachidonic acid) using gas chromatography.

Results: The serum fatty acid levels C18 : 3n and C20 : 4 were higher in the 320 mg group than in the 160 mg group, with statistical significance. After evening primrose oil treatment, EASI scores were reduced in the 2 groups. The improvement in EASI scores was greater in the 320 mg group than in the 160 mg group. There were no side effects seen in either group during the study in the 2 groups.

Conclusion: The results of this study suggest that the 320 mg and 160 mg groups may be equally effective in treating AD patients and show dose-dependent effects on serum fatty acid levels and EASI scores.

No MeSH data available.


Related in: MedlinePlus