Limits...
Dose-dependent effects of evening primrose oil in children and adolescents with atopic dermatitis.

Chung BY, Kim JH, Cho SI, Ahn IS, Kim HO, Park CW, Lee CH - Ann Dermatol (2013)

Bottom Line: The aim of this study is to investigate the dose-response treatment effects of evening primrose oil on clinical symptoms of AD and serum concentrations of polyunsaturated fatty acids.The serum fatty acid levels C18 : 3n and C20 : 4 were higher in the 320 mg group than in the 160 mg group, with statistical significance.There were no side effects seen in either group during the study in the 2 groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea.

ABSTRACT

Background: Previous clinical trials with evening primrose oil in atopic dermatitis (AD) treatment have shown different results. In addition, the optimal dose and duration of treatment with evening primrose oil have not yet been determined.

Objective: The aim of this study is to investigate the dose-response treatment effects of evening primrose oil on clinical symptoms of AD and serum concentrations of polyunsaturated fatty acids.

Methods: Forty AD patients were enrolled for the study and randomly divided into 2 groups: those who received evening primrose oil 160 mg daily for 8 weeks and those who received 320 mg of evening primrose oil twice daily for 8 weeks. We evaluated the Eczema Area Severity Index (EASI) scores of all AD patients at weeks 0, 2, 4 and 8. In addition, we measured the levels of serum fatty acids, including C16 : 0 (palmitic), C18 : 2n (linoleic), C18 : 3n (linolenic) and C20 : 4 (arachidonic acid) using gas chromatography.

Results: The serum fatty acid levels C18 : 3n and C20 : 4 were higher in the 320 mg group than in the 160 mg group, with statistical significance. After evening primrose oil treatment, EASI scores were reduced in the 2 groups. The improvement in EASI scores was greater in the 320 mg group than in the 160 mg group. There were no side effects seen in either group during the study in the 2 groups.

Conclusion: The results of this study suggest that the 320 mg and 160 mg groups may be equally effective in treating AD patients and show dose-dependent effects on serum fatty acid levels and EASI scores.

No MeSH data available.


Related in: MedlinePlus

Changes in serum fatty acid levels after treatment with evening primrose oil. (A) In the 160 mg group, all serum fatty acid levels increased, but only the increases in the levels of C18 : 3n (linolenic acid) and C20 : 4 (arachidonic acid) were statistically significant. *p=0.006, **p=0.006. (B) In the 320 mg group, all serum fatty acid levels increased, but significant differences were only noted in the serum levels of C18:3n (linolenic acid) and C20:4 (arachidonic acid). *p=0.001, **p=0.000.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3756191&req=5

Figure 1: Changes in serum fatty acid levels after treatment with evening primrose oil. (A) In the 160 mg group, all serum fatty acid levels increased, but only the increases in the levels of C18 : 3n (linolenic acid) and C20 : 4 (arachidonic acid) were statistically significant. *p=0.006, **p=0.006. (B) In the 320 mg group, all serum fatty acid levels increased, but significant differences were only noted in the serum levels of C18:3n (linolenic acid) and C20:4 (arachidonic acid). *p=0.001, **p=0.000.

Mentions: In the 160 mg group, the serum levels of C16:0 (palmitic acid) changed from 0.242±0.026 nmol/L to 0.251±0.125 nmol/L. The C18 : 2n (linoleic acid) level changed from 0.282±0.035 nmol/L to 0.301±0.153 nmol/L; C18 : 3n (linolenic acid) changed from 0.005±0.002 nmol/L to 0.008±0.004 nmol/L, and those of C20:4 (AA) rose from 0.059±0.011 nmol/L to 0.079±0.025 nmol/L. All of the fatty acid levels increased, but only the levels of C18 : 3n (linolenic acid) and C20:4 (AA) showed a significant change (p=0.006 and p=0.006, respectively) (Fig. 1A).


Dose-dependent effects of evening primrose oil in children and adolescents with atopic dermatitis.

Chung BY, Kim JH, Cho SI, Ahn IS, Kim HO, Park CW, Lee CH - Ann Dermatol (2013)

Changes in serum fatty acid levels after treatment with evening primrose oil. (A) In the 160 mg group, all serum fatty acid levels increased, but only the increases in the levels of C18 : 3n (linolenic acid) and C20 : 4 (arachidonic acid) were statistically significant. *p=0.006, **p=0.006. (B) In the 320 mg group, all serum fatty acid levels increased, but significant differences were only noted in the serum levels of C18:3n (linolenic acid) and C20:4 (arachidonic acid). *p=0.001, **p=0.000.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3756191&req=5

Figure 1: Changes in serum fatty acid levels after treatment with evening primrose oil. (A) In the 160 mg group, all serum fatty acid levels increased, but only the increases in the levels of C18 : 3n (linolenic acid) and C20 : 4 (arachidonic acid) were statistically significant. *p=0.006, **p=0.006. (B) In the 320 mg group, all serum fatty acid levels increased, but significant differences were only noted in the serum levels of C18:3n (linolenic acid) and C20:4 (arachidonic acid). *p=0.001, **p=0.000.
Mentions: In the 160 mg group, the serum levels of C16:0 (palmitic acid) changed from 0.242±0.026 nmol/L to 0.251±0.125 nmol/L. The C18 : 2n (linoleic acid) level changed from 0.282±0.035 nmol/L to 0.301±0.153 nmol/L; C18 : 3n (linolenic acid) changed from 0.005±0.002 nmol/L to 0.008±0.004 nmol/L, and those of C20:4 (AA) rose from 0.059±0.011 nmol/L to 0.079±0.025 nmol/L. All of the fatty acid levels increased, but only the levels of C18 : 3n (linolenic acid) and C20:4 (AA) showed a significant change (p=0.006 and p=0.006, respectively) (Fig. 1A).

Bottom Line: The aim of this study is to investigate the dose-response treatment effects of evening primrose oil on clinical symptoms of AD and serum concentrations of polyunsaturated fatty acids.The serum fatty acid levels C18 : 3n and C20 : 4 were higher in the 320 mg group than in the 160 mg group, with statistical significance.There were no side effects seen in either group during the study in the 2 groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea.

ABSTRACT

Background: Previous clinical trials with evening primrose oil in atopic dermatitis (AD) treatment have shown different results. In addition, the optimal dose and duration of treatment with evening primrose oil have not yet been determined.

Objective: The aim of this study is to investigate the dose-response treatment effects of evening primrose oil on clinical symptoms of AD and serum concentrations of polyunsaturated fatty acids.

Methods: Forty AD patients were enrolled for the study and randomly divided into 2 groups: those who received evening primrose oil 160 mg daily for 8 weeks and those who received 320 mg of evening primrose oil twice daily for 8 weeks. We evaluated the Eczema Area Severity Index (EASI) scores of all AD patients at weeks 0, 2, 4 and 8. In addition, we measured the levels of serum fatty acids, including C16 : 0 (palmitic), C18 : 2n (linoleic), C18 : 3n (linolenic) and C20 : 4 (arachidonic acid) using gas chromatography.

Results: The serum fatty acid levels C18 : 3n and C20 : 4 were higher in the 320 mg group than in the 160 mg group, with statistical significance. After evening primrose oil treatment, EASI scores were reduced in the 2 groups. The improvement in EASI scores was greater in the 320 mg group than in the 160 mg group. There were no side effects seen in either group during the study in the 2 groups.

Conclusion: The results of this study suggest that the 320 mg and 160 mg groups may be equally effective in treating AD patients and show dose-dependent effects on serum fatty acid levels and EASI scores.

No MeSH data available.


Related in: MedlinePlus