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A case of fixed drug eruption due to doxycycline and erythromycin present in food.

Lim WS, Kim DH, Jin SY, Choi YS, Lee SH, Huh HJ, Chae SL, Lee AY - Allergy Asthma Immunol Res (2013)

Bottom Line: She denied taking any medications, but she thought that the lesions appeared after consuming pork and/or fish.Because of the antibiotics' thermostability, cooking does not guarantee the elimination of residual drugs.From the patient's history, we concluded that doxycycline and erythromycin contained in the pork and fish that she ate were the cause of the FDE.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Dongguk University Ilsan Hospital, College of Medicine, Dongguk University, Goyang, Korea.

ABSTRACT
A fixed drug eruption (FDE) is not difficult to diagnose, given its clinical characteristics. However, the causative agent can be difficult to identify, particularly when the patient denies ingestion of any drugs. To the best of our knowledge, we present herein the first reported case of an FDE caused by antibiotics taken in food; doxycycline and erythromycin contained in pork and fish. A 57-year-old female experienced repeated episodes of well-demarcated erythematous patches covering her entire body. She denied taking any medications, but she thought that the lesions appeared after consuming pork and/or fish. An oral provocation test showed positive results for doxycycline and erythromycin, commonly used antibiotics in live-stock farming and in the fishing industry. Because of the antibiotics' thermostability, cooking does not guarantee the elimination of residual drugs. From the patient's history, we concluded that doxycycline and erythromycin contained in the pork and fish that she ate were the cause of the FDE.

No MeSH data available.


Related in: MedlinePlus

The disk-diffusion method for doxycycline and erythromycin. There are no significant differences in the zones of inhibition at various temperatures or with the concentrations of doxycycline and erythromycin.
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Figure 2: The disk-diffusion method for doxycycline and erythromycin. There are no significant differences in the zones of inhibition at various temperatures or with the concentrations of doxycycline and erythromycin.

Mentions: Interestingly, the patient had no history of taking medication, including doxycycline or erythromycin. According to the Korea Food and Drug Administration, doxycycline and erythromycin are commonly used in livestock farming and sea farming in Korea. We did not know whether antibiotics in food cooked at high temperatures could induce an FDE, so we conducted a simple experiment to assess the heat stability of doxycycline and erythromycin. Using the disk-diffusion method, we found that doxycycline and erythromycin are stable at 100℃ and even at autoclave temperatures reaching 121℃ (Fig. 2).


A case of fixed drug eruption due to doxycycline and erythromycin present in food.

Lim WS, Kim DH, Jin SY, Choi YS, Lee SH, Huh HJ, Chae SL, Lee AY - Allergy Asthma Immunol Res (2013)

The disk-diffusion method for doxycycline and erythromycin. There are no significant differences in the zones of inhibition at various temperatures or with the concentrations of doxycycline and erythromycin.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3756182&req=5

Figure 2: The disk-diffusion method for doxycycline and erythromycin. There are no significant differences in the zones of inhibition at various temperatures or with the concentrations of doxycycline and erythromycin.
Mentions: Interestingly, the patient had no history of taking medication, including doxycycline or erythromycin. According to the Korea Food and Drug Administration, doxycycline and erythromycin are commonly used in livestock farming and sea farming in Korea. We did not know whether antibiotics in food cooked at high temperatures could induce an FDE, so we conducted a simple experiment to assess the heat stability of doxycycline and erythromycin. Using the disk-diffusion method, we found that doxycycline and erythromycin are stable at 100℃ and even at autoclave temperatures reaching 121℃ (Fig. 2).

Bottom Line: She denied taking any medications, but she thought that the lesions appeared after consuming pork and/or fish.Because of the antibiotics' thermostability, cooking does not guarantee the elimination of residual drugs.From the patient's history, we concluded that doxycycline and erythromycin contained in the pork and fish that she ate were the cause of the FDE.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Dongguk University Ilsan Hospital, College of Medicine, Dongguk University, Goyang, Korea.

ABSTRACT
A fixed drug eruption (FDE) is not difficult to diagnose, given its clinical characteristics. However, the causative agent can be difficult to identify, particularly when the patient denies ingestion of any drugs. To the best of our knowledge, we present herein the first reported case of an FDE caused by antibiotics taken in food; doxycycline and erythromycin contained in pork and fish. A 57-year-old female experienced repeated episodes of well-demarcated erythematous patches covering her entire body. She denied taking any medications, but she thought that the lesions appeared after consuming pork and/or fish. An oral provocation test showed positive results for doxycycline and erythromycin, commonly used antibiotics in live-stock farming and in the fishing industry. Because of the antibiotics' thermostability, cooking does not guarantee the elimination of residual drugs. From the patient's history, we concluded that doxycycline and erythromycin contained in the pork and fish that she ate were the cause of the FDE.

No MeSH data available.


Related in: MedlinePlus