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Usefulness of Colored 3D Imaging of Respiratory Impedance in Asthma.

Shirai T, Mori K, Mikamo M, Shishido Y, Akita T, Morita S, Asada K, Fujii M, Suda T, Chida K - Allergy Asthma Immunol Res (2013)

Bottom Line: The classification was performed by three researchers, who were unaware of the clinical information, and the clinical characteristics were compared among the three groups.Patients with the COPD-like pattern were predominantly female with a higher body mass index, lower forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC), and higher Rrs and Xrs values (whole-breath and within-breath variation).Those with the normal pattern had higher FEV1 and FVC, and a lower single-breath nitrogen washout slope.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan.

ABSTRACT

Purpose: Recently, the clinical application of the forced oscillation technique (FOT) has progressed with the spread of commercially available FOT devices, including the impulse oscillation system and MostGraph. We investigated the usefulness of color 3D imaging of respiratory impedance in asthma using MostGraph.

Methods: Whole-breath and within-breath respiratory system resistance (Rrs) and reactance (Xrs) were measured in 78 patients with asthma. Color 3D images were classified into three patterns: the chronic obstructive pulmonary disease (COPD)-like pattern (high values of Rrs and Xrs with a marked respiratory cycle and frequency dependence), the asthma pattern (moderately high Rrs over the entire frequency and a respiratory cycle with slight Xrs changes), and a normal-like pattern (low Rrs and Xrs with few within-breath changes). The classification was performed by three researchers, who were unaware of the clinical information, and the clinical characteristics were compared among the three groups.

Results: Color 3D imaging provided a COPD-like pattern in 25 patients, an asthma pattern in 39 patients, and a normal-like pattern in 14 patients. Patients with the COPD-like pattern were predominantly female with a higher body mass index, lower forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC), and higher Rrs and Xrs values (whole-breath and within-breath variation). Those with the normal pattern had higher FEV1 and FVC, and a lower single-breath nitrogen washout slope. There were no differences in asthma control or exhaled nitric oxide levels among the three groups.

Conclusions: These results suggest that color 3D imaging of respiratory impedance may show asthma phenotypes.

No MeSH data available.


Related in: MedlinePlus

Color 3D imaging patterns of respiratory impedance in patients with asthma. Color 3D images were classified visually into COPD-like, asthma, and normal-like patterns by three researchers who were unaware of the clinical information and classified images by a majority decision when necessary. The COPD-like pattern corresponded to the pattern usually found in patients with COPD, while the normal-like pattern corresponded to the pattern usually found in normal controls.
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Figure 2: Color 3D imaging patterns of respiratory impedance in patients with asthma. Color 3D images were classified visually into COPD-like, asthma, and normal-like patterns by three researchers who were unaware of the clinical information and classified images by a majority decision when necessary. The COPD-like pattern corresponded to the pattern usually found in patients with COPD, while the normal-like pattern corresponded to the pattern usually found in normal controls.

Mentions: According to our previous report,7 color 3D imaging of respiratory impedance provided three patterns in each representative subject (Fig. 1). The criteria consisted of the following: 1) high values of Rrs and Xrs (blue or black at the top and bottom, that is, the top ≥6 cmH2O/L/s and the bottom <-6 cmH2O/L/s) with a marked respiratory cycle and frequency dependence, which was usually found in patients with COPD; 2) moderately high Rrs over the entire frequency and respiratory cycle (yellow, orange, or red, that is, the top ≥2-<6 cmH2O/L/s) with slight Xrs changes (yellow), which was usually found in patients with asthma; and 3) low Rrs (green, that is, the top <2 cmH2O/L/s) and Xrs (yellow) with few within-breath changes, which was usually found in healthy controls. Because these patterns were not disease-specific, but rather disease-suggestive, different color 3D imaging patterns can occur in patients with asthma. Three researchers (K. M., M. M., and S. M.) classified each asthma patient's color 3D imaging visually into the COPD-like pattern, asthma pattern, and normal-like pattern (Fig. 2); they were unaware of the clinical information and classified the images based on a majority decision when necessary. The COPD-like pattern refers to the typical color 3D imaging pattern that is observed in many patients with COPD, while the normal-like pattern refers to the one that is observed in many normal controls.


Usefulness of Colored 3D Imaging of Respiratory Impedance in Asthma.

Shirai T, Mori K, Mikamo M, Shishido Y, Akita T, Morita S, Asada K, Fujii M, Suda T, Chida K - Allergy Asthma Immunol Res (2013)

Color 3D imaging patterns of respiratory impedance in patients with asthma. Color 3D images were classified visually into COPD-like, asthma, and normal-like patterns by three researchers who were unaware of the clinical information and classified images by a majority decision when necessary. The COPD-like pattern corresponded to the pattern usually found in patients with COPD, while the normal-like pattern corresponded to the pattern usually found in normal controls.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3756180&req=5

Figure 2: Color 3D imaging patterns of respiratory impedance in patients with asthma. Color 3D images were classified visually into COPD-like, asthma, and normal-like patterns by three researchers who were unaware of the clinical information and classified images by a majority decision when necessary. The COPD-like pattern corresponded to the pattern usually found in patients with COPD, while the normal-like pattern corresponded to the pattern usually found in normal controls.
Mentions: According to our previous report,7 color 3D imaging of respiratory impedance provided three patterns in each representative subject (Fig. 1). The criteria consisted of the following: 1) high values of Rrs and Xrs (blue or black at the top and bottom, that is, the top ≥6 cmH2O/L/s and the bottom <-6 cmH2O/L/s) with a marked respiratory cycle and frequency dependence, which was usually found in patients with COPD; 2) moderately high Rrs over the entire frequency and respiratory cycle (yellow, orange, or red, that is, the top ≥2-<6 cmH2O/L/s) with slight Xrs changes (yellow), which was usually found in patients with asthma; and 3) low Rrs (green, that is, the top <2 cmH2O/L/s) and Xrs (yellow) with few within-breath changes, which was usually found in healthy controls. Because these patterns were not disease-specific, but rather disease-suggestive, different color 3D imaging patterns can occur in patients with asthma. Three researchers (K. M., M. M., and S. M.) classified each asthma patient's color 3D imaging visually into the COPD-like pattern, asthma pattern, and normal-like pattern (Fig. 2); they were unaware of the clinical information and classified the images based on a majority decision when necessary. The COPD-like pattern refers to the typical color 3D imaging pattern that is observed in many patients with COPD, while the normal-like pattern refers to the one that is observed in many normal controls.

Bottom Line: The classification was performed by three researchers, who were unaware of the clinical information, and the clinical characteristics were compared among the three groups.Patients with the COPD-like pattern were predominantly female with a higher body mass index, lower forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC), and higher Rrs and Xrs values (whole-breath and within-breath variation).Those with the normal pattern had higher FEV1 and FVC, and a lower single-breath nitrogen washout slope.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan.

ABSTRACT

Purpose: Recently, the clinical application of the forced oscillation technique (FOT) has progressed with the spread of commercially available FOT devices, including the impulse oscillation system and MostGraph. We investigated the usefulness of color 3D imaging of respiratory impedance in asthma using MostGraph.

Methods: Whole-breath and within-breath respiratory system resistance (Rrs) and reactance (Xrs) were measured in 78 patients with asthma. Color 3D images were classified into three patterns: the chronic obstructive pulmonary disease (COPD)-like pattern (high values of Rrs and Xrs with a marked respiratory cycle and frequency dependence), the asthma pattern (moderately high Rrs over the entire frequency and a respiratory cycle with slight Xrs changes), and a normal-like pattern (low Rrs and Xrs with few within-breath changes). The classification was performed by three researchers, who were unaware of the clinical information, and the clinical characteristics were compared among the three groups.

Results: Color 3D imaging provided a COPD-like pattern in 25 patients, an asthma pattern in 39 patients, and a normal-like pattern in 14 patients. Patients with the COPD-like pattern were predominantly female with a higher body mass index, lower forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC), and higher Rrs and Xrs values (whole-breath and within-breath variation). Those with the normal pattern had higher FEV1 and FVC, and a lower single-breath nitrogen washout slope. There were no differences in asthma control or exhaled nitric oxide levels among the three groups.

Conclusions: These results suggest that color 3D imaging of respiratory impedance may show asthma phenotypes.

No MeSH data available.


Related in: MedlinePlus