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The allergenic potency of Japanese hop pollen is increasing with environmental changes in Korea.

Jin HJ, Choi GS, Shin YS, Kim JH, Kim JE, Ye YM, Park HS - Allergy Asthma Immunol Res (2013)

Bottom Line: IgE binding components were compared by IgE immunoblot analysis.Serum specific IgE levels to the 09 and urban extracts in both groups increased significantly compared to those of the 98 and suburban extracts.When the 98 and 09 extracts were compared, intensification of the major allergen of 09 extract had occurred in both groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea. ; Center for Respiratory Disease, Yeungnam University Medical Center, Daegu, Korea.

ABSTRACT

Purpose: The sensitization rate to Japanese Hop (Hop J) in respiratory allergy patients has increased in recent years in Korea. We evaluated changes in the allergenic potency of Hop J pollen collected in 1998 and 2009.

Methods: Thirty-five patients with allergic rhinitis and/or asthma were enrolled. Group I included 21 subjects sensitized to Hop J at an initial visit and group II included 14 subjects who developed a new sensitization. Hop J pollens were collected in 1998 and 2009 (98 and 09 extracts) and both urban and suburban environments (urban and suburban extracts). Serum specific IgE levels to Hop J pollen extracts were compared using an enzyme-linked immunosorbent assay (ELISA). IgE binding components were compared by IgE immunoblot analysis.

Results: Serum specific IgE levels to the 09 and urban extracts in both groups increased significantly compared to those of the 98 and suburban extracts. IgE immunoblot demonstrated that the major 10 kDa allergen was intensified in group I, while it was newly generated in group II with additional components ranging from 12-95 kDa. When the 98 and 09 extracts were compared, intensification of the major allergen of 09 extract had occurred in both groups. The IgE binding components of the urban extract was stronger than those of suburban one.

Conclusions: The allergenic potency of Hop J pollen may be increased with environmental changes.

No MeSH data available.


Related in: MedlinePlus

Comparison of serum specific IgE levels against four different Hop J pollen extracts, i.e., the 98 and 09 extracts (A), and the urban and suburban extracts (B), in groups I and II subjects using enzyme-linked immunosorbent assay. P values were determined by a Wilcoxon signed rank test. Horizontal bar indicates the mean value.
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Figure 1: Comparison of serum specific IgE levels against four different Hop J pollen extracts, i.e., the 98 and 09 extracts (A), and the urban and suburban extracts (B), in groups I and II subjects using enzyme-linked immunosorbent assay. P values were determined by a Wilcoxon signed rank test. Horizontal bar indicates the mean value.

Mentions: The serum specific IgE levels to the 98 extracts were not significantly different between the two groups (P=0.893); however, serum specific IgE levels to the 09 extracts were significantly higher than those of the 98 extracts in both groups (P<0.001, P=0.006, respectively; Fig. 1A). Moreover, when serum specific IgE levels to the 09 Hop J extracts from urban and suburban areas were compared, those to the urban extracts were significantly higher than those to the suburban in both groups (P<0.001, P=0.001; Fig. 1B).


The allergenic potency of Japanese hop pollen is increasing with environmental changes in Korea.

Jin HJ, Choi GS, Shin YS, Kim JH, Kim JE, Ye YM, Park HS - Allergy Asthma Immunol Res (2013)

Comparison of serum specific IgE levels against four different Hop J pollen extracts, i.e., the 98 and 09 extracts (A), and the urban and suburban extracts (B), in groups I and II subjects using enzyme-linked immunosorbent assay. P values were determined by a Wilcoxon signed rank test. Horizontal bar indicates the mean value.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3756178&req=5

Figure 1: Comparison of serum specific IgE levels against four different Hop J pollen extracts, i.e., the 98 and 09 extracts (A), and the urban and suburban extracts (B), in groups I and II subjects using enzyme-linked immunosorbent assay. P values were determined by a Wilcoxon signed rank test. Horizontal bar indicates the mean value.
Mentions: The serum specific IgE levels to the 98 extracts were not significantly different between the two groups (P=0.893); however, serum specific IgE levels to the 09 extracts were significantly higher than those of the 98 extracts in both groups (P<0.001, P=0.006, respectively; Fig. 1A). Moreover, when serum specific IgE levels to the 09 Hop J extracts from urban and suburban areas were compared, those to the urban extracts were significantly higher than those to the suburban in both groups (P<0.001, P=0.001; Fig. 1B).

Bottom Line: IgE binding components were compared by IgE immunoblot analysis.Serum specific IgE levels to the 09 and urban extracts in both groups increased significantly compared to those of the 98 and suburban extracts.When the 98 and 09 extracts were compared, intensification of the major allergen of 09 extract had occurred in both groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea. ; Center for Respiratory Disease, Yeungnam University Medical Center, Daegu, Korea.

ABSTRACT

Purpose: The sensitization rate to Japanese Hop (Hop J) in respiratory allergy patients has increased in recent years in Korea. We evaluated changes in the allergenic potency of Hop J pollen collected in 1998 and 2009.

Methods: Thirty-five patients with allergic rhinitis and/or asthma were enrolled. Group I included 21 subjects sensitized to Hop J at an initial visit and group II included 14 subjects who developed a new sensitization. Hop J pollens were collected in 1998 and 2009 (98 and 09 extracts) and both urban and suburban environments (urban and suburban extracts). Serum specific IgE levels to Hop J pollen extracts were compared using an enzyme-linked immunosorbent assay (ELISA). IgE binding components were compared by IgE immunoblot analysis.

Results: Serum specific IgE levels to the 09 and urban extracts in both groups increased significantly compared to those of the 98 and suburban extracts. IgE immunoblot demonstrated that the major 10 kDa allergen was intensified in group I, while it was newly generated in group II with additional components ranging from 12-95 kDa. When the 98 and 09 extracts were compared, intensification of the major allergen of 09 extract had occurred in both groups. The IgE binding components of the urban extract was stronger than those of suburban one.

Conclusions: The allergenic potency of Hop J pollen may be increased with environmental changes.

No MeSH data available.


Related in: MedlinePlus