Limits...
Sex differences in adipose tissue: It is not only a question of quantity and distribution.

Fuente-Martín E, Argente-Arizón P, Ros P, Argente J, Chowen JA - Adipocyte (2013)

Bottom Line: As a result of this intensified research numerous differences between males and females at all levels of metabolic control have come to the forefront.These differences include not only the amount and distribution of adipose tissue, but also differences in its metabolic capacity and functions between the sexes.Here, we review some of the recent advances in our understanding of these dimorphisms and emphasize the fact that these differences between males and females must be taken into consideration in hopes of obtaining successful treatments for both sexes.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatric Endocrinology; Hospital Infantil Universitario Niño Jesús; Instituto de Investigación La Princesa; Madrid, Spain ; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn); Instituto de Salud Carlos III; Madrid, Spain.

ABSTRACT
Obesity and its associated secondary complications are active areas of investigation in search of effective treatments. As a result of this intensified research numerous differences between males and females at all levels of metabolic control have come to the forefront. These differences include not only the amount and distribution of adipose tissue, but also differences in its metabolic capacity and functions between the sexes. Here, we review some of the recent advances in our understanding of these dimorphisms and emphasize the fact that these differences between males and females must be taken into consideration in hopes of obtaining successful treatments for both sexes.

No MeSH data available.


Related in: MedlinePlus

Figure 1. Schematic summary of the differences between adipose tissue from males and females discussed in this review. The genetic make-up and basal gene expression of adipose tissue differs between the sexes. This, in addition to diverse signals and inputs to adipose tissue that differ between males and females, results in differences in the quantity and distribution of adipose tissue, as well as its responses and outputs.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3756100&req=5

Figure 1: Figure 1. Schematic summary of the differences between adipose tissue from males and females discussed in this review. The genetic make-up and basal gene expression of adipose tissue differs between the sexes. This, in addition to diverse signals and inputs to adipose tissue that differ between males and females, results in differences in the quantity and distribution of adipose tissue, as well as its responses and outputs.

Mentions: There are clear differences in the white adipose tissue of males and females at many levels (Fig. 1) including quantity, distribution, metabolic capacity, inputs, etc. Some of these differences are due to direct activational effects of sex steroids or are mediated indirectly through other factors that are modified by sex steroids, while others appear to be inherent to each sex and thus not sex steroid-dependent. Here we have briefly reviewed some of the recent advances in delineating the mechanisms underlying this important aspect of adipose tissue, but much is yet to be learned. Understanding these differences and the mechanisms involved will undoubtedly lead to better therapies for the treatment of obesity and its complications, with some of these treatments surely having different efficaciousness in males and females.


Sex differences in adipose tissue: It is not only a question of quantity and distribution.

Fuente-Martín E, Argente-Arizón P, Ros P, Argente J, Chowen JA - Adipocyte (2013)

Figure 1. Schematic summary of the differences between adipose tissue from males and females discussed in this review. The genetic make-up and basal gene expression of adipose tissue differs between the sexes. This, in addition to diverse signals and inputs to adipose tissue that differ between males and females, results in differences in the quantity and distribution of adipose tissue, as well as its responses and outputs.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3756100&req=5

Figure 1: Figure 1. Schematic summary of the differences between adipose tissue from males and females discussed in this review. The genetic make-up and basal gene expression of adipose tissue differs between the sexes. This, in addition to diverse signals and inputs to adipose tissue that differ between males and females, results in differences in the quantity and distribution of adipose tissue, as well as its responses and outputs.
Mentions: There are clear differences in the white adipose tissue of males and females at many levels (Fig. 1) including quantity, distribution, metabolic capacity, inputs, etc. Some of these differences are due to direct activational effects of sex steroids or are mediated indirectly through other factors that are modified by sex steroids, while others appear to be inherent to each sex and thus not sex steroid-dependent. Here we have briefly reviewed some of the recent advances in delineating the mechanisms underlying this important aspect of adipose tissue, but much is yet to be learned. Understanding these differences and the mechanisms involved will undoubtedly lead to better therapies for the treatment of obesity and its complications, with some of these treatments surely having different efficaciousness in males and females.

Bottom Line: As a result of this intensified research numerous differences between males and females at all levels of metabolic control have come to the forefront.These differences include not only the amount and distribution of adipose tissue, but also differences in its metabolic capacity and functions between the sexes.Here, we review some of the recent advances in our understanding of these dimorphisms and emphasize the fact that these differences between males and females must be taken into consideration in hopes of obtaining successful treatments for both sexes.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatric Endocrinology; Hospital Infantil Universitario Niño Jesús; Instituto de Investigación La Princesa; Madrid, Spain ; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn); Instituto de Salud Carlos III; Madrid, Spain.

ABSTRACT
Obesity and its associated secondary complications are active areas of investigation in search of effective treatments. As a result of this intensified research numerous differences between males and females at all levels of metabolic control have come to the forefront. These differences include not only the amount and distribution of adipose tissue, but also differences in its metabolic capacity and functions between the sexes. Here, we review some of the recent advances in our understanding of these dimorphisms and emphasize the fact that these differences between males and females must be taken into consideration in hopes of obtaining successful treatments for both sexes.

No MeSH data available.


Related in: MedlinePlus