Limits...
A meta-analysis of the association between the CC chemokine ligand 5 (CCL5) -403 G>A gene polymorphism and tuberculosis susceptibility.

Areeshi MY, Mandal RK, Panda AK, Haque S - PLoS ONE (2013)

Bottom Line: GG; p = 0.001; OR = 1.520, 95% CI = 1.202 to 1.923) carriers were significantly associated with TB susceptibility.GG: p = 0.222; OR = 1.188, 95% CI = 0.901 to 1.567) models failed to show increased risk of developing TB.This meta-analysis suggests that there is a significant association between the CCL5 -403 G>A polymorphism and increased risk of TB.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Microbiology, College of Nursing and Allied Health Sciences, Jazan University, Jazan, Saudi Arabia.

ABSTRACT

Aim: Many case-control studies have been performed in the recent past to investigate the association between CCL5 -403 G>A (rs2107538) gene polymorphism and tuberculosis (TB) susceptibility in various ethnic groups. However, these studies have produced inconsistent and contradictory results. In the present study, meta-analysis was performed to assess the association between CCL5 -403 G>A polymorphism and TB risk.

Methodology: Quantitative synthesis was done for the published studies based upon association between CCL5 -403 G>A polymorphism and TB risk from PubMed (Medline), EMBASE web search. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for allele contrast, homozygous, heterozygous, dominant and recessive genetic models.

Results: A total of six studies comprising 1638 confirmed TB cases and 1519 healthy controls were included in this meta-analysis. Variant A allele (A vs. G: p = 0.035; OR = 1.301, 95% CI = 1.019 to 1.662) and variant homozygous (AA vs. GG; p = 0.001; OR = 1.520, 95% CI = 1.202 to 1.923) carriers were significantly associated with TB susceptibility. Similarly, recessive model (AA vs. GG+GA: p = 0.016; OR = 1.791, 95% CI = 1.117 to 2.873) also indicated increased TB risk. Whereas, heterozygous (GA vs. GG: p = 0.837; OR = 1.028, 95% CI = 0.791 to 1.335) and dominant (AA+GA vs. GG: p = 0.222; OR = 1.188, 95% CI = 0.901 to 1.567) models failed to show increased risk of developing TB.

Conclusions: This meta-analysis suggests that there is a significant association between the CCL5 -403 G>A polymorphism and increased risk of TB. However, larger well-designed epidemiological studies with stratified case control and biological characterization may be helpful to validate this association.

Show MeSH

Related in: MedlinePlus

Forest plot and ORs with 95% CI of CCL5 -403G>A polymorphism and TB risk (A vs. G).
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3756059&req=5

pone-0072139-g001: Forest plot and ORs with 95% CI of CCL5 -403G>A polymorphism and TB risk (A vs. G).

Mentions: All six studies were pooled together which resulted into 1638 confirm TB cases and 1519 controls, and the random effects model (based on heterogeneity) was employed to evaluate the overall association between the CCL5 -409 G>A polymorphism and TB susceptibility. The pooled results demonstrated that variant allele A was significantly associated with increased risk of TB (A vs. G: p = 0.035; OR = 1.301, 95% CI = 1.019 to 1.662) (Figure 1). Mutant homozygous genotype AA showed 1.5 fold increased TB risk (AA vs. GG; p = 0.001; OR = 1.520, 95% CI = 1.202 to 1.923) compare with wild type homozygous GG (Figure 2). Furthermore, recessive genetic model also indicated 1.7 fold increased risk of TB (AA vs. GG+GA: p = 0.016; OR = 1.791, 95% CI = 1.117 to 2.873) (Figure 3). However, heterozygous GA genotype (GA vs. GG: p = 0.837; OR = 1.028, 95% CI = 0.791 to 1.335) (Figure 4) and dominant (AA+GA vs. GG: p = 0.222; OR = 1.188, 95% CI = 0.901 to 1.567) model failed to show any altered risk for TB occurrence (Figure 5).


A meta-analysis of the association between the CC chemokine ligand 5 (CCL5) -403 G>A gene polymorphism and tuberculosis susceptibility.

Areeshi MY, Mandal RK, Panda AK, Haque S - PLoS ONE (2013)

Forest plot and ORs with 95% CI of CCL5 -403G>A polymorphism and TB risk (A vs. G).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3756059&req=5

pone-0072139-g001: Forest plot and ORs with 95% CI of CCL5 -403G>A polymorphism and TB risk (A vs. G).
Mentions: All six studies were pooled together which resulted into 1638 confirm TB cases and 1519 controls, and the random effects model (based on heterogeneity) was employed to evaluate the overall association between the CCL5 -409 G>A polymorphism and TB susceptibility. The pooled results demonstrated that variant allele A was significantly associated with increased risk of TB (A vs. G: p = 0.035; OR = 1.301, 95% CI = 1.019 to 1.662) (Figure 1). Mutant homozygous genotype AA showed 1.5 fold increased TB risk (AA vs. GG; p = 0.001; OR = 1.520, 95% CI = 1.202 to 1.923) compare with wild type homozygous GG (Figure 2). Furthermore, recessive genetic model also indicated 1.7 fold increased risk of TB (AA vs. GG+GA: p = 0.016; OR = 1.791, 95% CI = 1.117 to 2.873) (Figure 3). However, heterozygous GA genotype (GA vs. GG: p = 0.837; OR = 1.028, 95% CI = 0.791 to 1.335) (Figure 4) and dominant (AA+GA vs. GG: p = 0.222; OR = 1.188, 95% CI = 0.901 to 1.567) model failed to show any altered risk for TB occurrence (Figure 5).

Bottom Line: GG; p = 0.001; OR = 1.520, 95% CI = 1.202 to 1.923) carriers were significantly associated with TB susceptibility.GG: p = 0.222; OR = 1.188, 95% CI = 0.901 to 1.567) models failed to show increased risk of developing TB.This meta-analysis suggests that there is a significant association between the CCL5 -403 G>A polymorphism and increased risk of TB.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Microbiology, College of Nursing and Allied Health Sciences, Jazan University, Jazan, Saudi Arabia.

ABSTRACT

Aim: Many case-control studies have been performed in the recent past to investigate the association between CCL5 -403 G>A (rs2107538) gene polymorphism and tuberculosis (TB) susceptibility in various ethnic groups. However, these studies have produced inconsistent and contradictory results. In the present study, meta-analysis was performed to assess the association between CCL5 -403 G>A polymorphism and TB risk.

Methodology: Quantitative synthesis was done for the published studies based upon association between CCL5 -403 G>A polymorphism and TB risk from PubMed (Medline), EMBASE web search. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for allele contrast, homozygous, heterozygous, dominant and recessive genetic models.

Results: A total of six studies comprising 1638 confirmed TB cases and 1519 healthy controls were included in this meta-analysis. Variant A allele (A vs. G: p = 0.035; OR = 1.301, 95% CI = 1.019 to 1.662) and variant homozygous (AA vs. GG; p = 0.001; OR = 1.520, 95% CI = 1.202 to 1.923) carriers were significantly associated with TB susceptibility. Similarly, recessive model (AA vs. GG+GA: p = 0.016; OR = 1.791, 95% CI = 1.117 to 2.873) also indicated increased TB risk. Whereas, heterozygous (GA vs. GG: p = 0.837; OR = 1.028, 95% CI = 0.791 to 1.335) and dominant (AA+GA vs. GG: p = 0.222; OR = 1.188, 95% CI = 0.901 to 1.567) models failed to show increased risk of developing TB.

Conclusions: This meta-analysis suggests that there is a significant association between the CCL5 -403 G>A polymorphism and increased risk of TB. However, larger well-designed epidemiological studies with stratified case control and biological characterization may be helpful to validate this association.

Show MeSH
Related in: MedlinePlus