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Hypoxia-inducible factor-1α polymorphisms and risk of cancer metastasis: a meta-analysis.

Zhang Q, Chen Y, Zhang B, Shi B, Weng W, Chen Z, Guo N, Hua Y, Zhu L - PLoS ONE (2013)

Bottom Line: Many studies have demonstrated that hypoxia-inducible factor1-α (HIF-1α) polymorphisms are significantly associated with cancer metastasis, but the results are inconsistent.TC+ CC, OR  = 1.93, 95% CI  = 0.86-4.36).In the subgroup analyses, the significant associations remained significant among Asians, Caucasians and other cancers in the dominant model.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

ABSTRACT

Background: HIF-1α is a major regulator in tumor progression and metastasis which responds to hypoxia. Many studies have demonstrated that hypoxia-inducible factor1-α (HIF-1α) polymorphisms are significantly associated with cancer metastasis, but the results are inconsistent. We conducted a comprehensive meta-analysis to estimate the associations between HIF-1α C1772 T polymorphism and cancer metastasis.

Methods: Comprehensive searches were conducted on PubMed and EMBASE database. Fifteen studies were included in the meta-analysis. We used the OR and 95%CI to assess the associations between HIF-1α C1772T polymorphism and cancer metastasis. Heterogeneity and publication bias were also assessed by Q test, I (2), and funnel plot.

Results: Totally, fifteen studies including 1239 cases with metastasis-positive (M+) and 2711 cases with metastasis-negative (M-) were performed in this meta-analysis. The results showed that HIF-1a C1772T polymorphism was associated with the increased risk of cancer metastasis (T allele vs. C allele, OR  = 1.36, 95% CI  = 1.12-1.64; TT+ TC vs. CC, OR  = 1.39, 95% CI  = 1.13-1.71; TT vs. TC+ CC, OR  = 1.93, 95% CI  = 0.86-4.36). In the subgroup analyses, the significant associations remained significant among Asians, Caucasians and other cancers in the dominant model. Publication bias was not observed in the analysis.

Conclusions: Our results indicate that the HIF-1αC1772T polymorphism T allele may increase the risk of cancer metastasis, which might be a potential risk factor of cancer progress.

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Related in: MedlinePlus

The detailed process of identifying eligible studies.
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pone-0070961-g001: The detailed process of identifying eligible studies.

Mentions: 27 studies were obtained to evaluate the relationship between HIF-1α C1772 T and cancer metastasis. Twelve of them were excluded (8 studies were excluded for lacking of accurate staging, 4 studies without genotype data). Finally, 15 articles [29], [10]–[23] were included in our meta-analysis (Figure 1). The detail characteristics of eligible studies were summarized in Table 1. Among these studies, there were 10 studies of Asians and 5 of Caucasians. All studies were case-control studies which contained four studies with breast cancer, two with colorectal cancer and other cancers group. As shown in Table 1, 1239 (M+) cases and 2711 (M−) cases were included in the study.


Hypoxia-inducible factor-1α polymorphisms and risk of cancer metastasis: a meta-analysis.

Zhang Q, Chen Y, Zhang B, Shi B, Weng W, Chen Z, Guo N, Hua Y, Zhu L - PLoS ONE (2013)

The detailed process of identifying eligible studies.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3756035&req=5

pone-0070961-g001: The detailed process of identifying eligible studies.
Mentions: 27 studies were obtained to evaluate the relationship between HIF-1α C1772 T and cancer metastasis. Twelve of them were excluded (8 studies were excluded for lacking of accurate staging, 4 studies without genotype data). Finally, 15 articles [29], [10]–[23] were included in our meta-analysis (Figure 1). The detail characteristics of eligible studies were summarized in Table 1. Among these studies, there were 10 studies of Asians and 5 of Caucasians. All studies were case-control studies which contained four studies with breast cancer, two with colorectal cancer and other cancers group. As shown in Table 1, 1239 (M+) cases and 2711 (M−) cases were included in the study.

Bottom Line: Many studies have demonstrated that hypoxia-inducible factor1-α (HIF-1α) polymorphisms are significantly associated with cancer metastasis, but the results are inconsistent.TC+ CC, OR  = 1.93, 95% CI  = 0.86-4.36).In the subgroup analyses, the significant associations remained significant among Asians, Caucasians and other cancers in the dominant model.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

ABSTRACT

Background: HIF-1α is a major regulator in tumor progression and metastasis which responds to hypoxia. Many studies have demonstrated that hypoxia-inducible factor1-α (HIF-1α) polymorphisms are significantly associated with cancer metastasis, but the results are inconsistent. We conducted a comprehensive meta-analysis to estimate the associations between HIF-1α C1772 T polymorphism and cancer metastasis.

Methods: Comprehensive searches were conducted on PubMed and EMBASE database. Fifteen studies were included in the meta-analysis. We used the OR and 95%CI to assess the associations between HIF-1α C1772T polymorphism and cancer metastasis. Heterogeneity and publication bias were also assessed by Q test, I (2), and funnel plot.

Results: Totally, fifteen studies including 1239 cases with metastasis-positive (M+) and 2711 cases with metastasis-negative (M-) were performed in this meta-analysis. The results showed that HIF-1a C1772T polymorphism was associated with the increased risk of cancer metastasis (T allele vs. C allele, OR  = 1.36, 95% CI  = 1.12-1.64; TT+ TC vs. CC, OR  = 1.39, 95% CI  = 1.13-1.71; TT vs. TC+ CC, OR  = 1.93, 95% CI  = 0.86-4.36). In the subgroup analyses, the significant associations remained significant among Asians, Caucasians and other cancers in the dominant model. Publication bias was not observed in the analysis.

Conclusions: Our results indicate that the HIF-1αC1772T polymorphism T allele may increase the risk of cancer metastasis, which might be a potential risk factor of cancer progress.

Show MeSH
Related in: MedlinePlus