Limits...
Long-term dynamics of hematological data and spleen volume in cirrhotic patients after liver transplantation-various dynamics depending on etiology.

Ishigami M, Ishizu Y, Onishi Y, Kamei H, Kiuchi T, Itoh A, Hirooka Y, Katano Y, Goto H - Springerplus (2013)

Bottom Line: However, detailed dynamics, especially over a long term, are not fully understood.We studied 53 cirrhotic patients who underwent liver transplantation at our institute and followed for more than 1 year.Unique dynamics and correlations between them were found among the different etiologies investigated.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology and Hepatology, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550 Nagoya, Japan.

ABSTRACT

Background: Hypersplenism is a common complication in cirrhotic patients, and liver transplantation would be one of the effective treatments. However, detailed dynamics, especially over a long term, are not fully understood. We investigated the long-term dynamics of hematological data and spleen volumes, as well as their correlation in cirrhotic patients who underwent liver transplantation.

Patients and methods: We studied 53 cirrhotic patients who underwent liver transplantation at our institute and followed for more than 1 year. Hematological data were collected from medical records, while spleen volumes were determined by CT volumetry at 0, 1, 3, 6, 12, 24, 36, 48, 60 postoperative months (POM).

Results: (1) Platelet (Plt) and hemoglobin (Hb) levels were gradually increased up to 18 and 10 POM, respectively, in contrast with white blood cells (WBC), which remained mostly unchanged from pretransplantation levels. (2) Spleen volume was sharply decreased in the first POM, then showed a slower but steady decline up to 48 POM. (3) Spleen volume was significantly correlated with hematological data, though the levels were generally weak (Plt: r = 0.433, p < 0.001; Hb: r = 0.233, p < 0.001; WBC: r = 0.217, p = 0.001). (4) Spleen volume was strongly correlated with all hematological parameters in HBV patients (Plt: r = 0.617, p < 0.0001; Hb: r = 0.401, p < 0.001; WBC: r = 0.387, p < 0.001), in contrast with that in other etiologies, which had generally weak correlations though some were statistically significant.

Conclusions: We investigated the long-term dynamics of hematological data and spleen volume in cirrhotic patients after liver transplantation. Unique dynamics and correlations between them were found among the different etiologies investigated.

No MeSH data available.


Related in: MedlinePlus

Correlations between spleen volumes and each hematological parameter among different etiologies after liver transplantation. a. Correlation between Plt count and spleen volume in HBV, r = 0.617, p < 0.001, b. Correlation between Hb level and spleen volume in HBV, r = 0.401, p < 0.001, c. correlation between WBC count and spleen volume, r = 0.387, p < 0.001, d. Correlation between Plt count and spleen volume in HCV, r = 0.364, p < 0.001, e. Correlation between Hb level and spleen volume in HCV, r = 0.278, p = 0.079, f. Correlation between WBC count and spleen volume in HCV, r = 0.279, p = 0.078, g. Correlation between Plt count and spleen volume in PBC, r = 0.256, p = 0.09, h. Correlation between Hb level and spleen volume in PBC, r = 0.279, p < 0.001, i. Correlation between WBC count and spleen volume in PBC, r = 0.128, p = 0.314, j. Correlation between Plt count and spleen volume in NBNC, r = 0.660, p < 0.001, k. Correlation between Hb level and spleen volume in NBNC, r = 0.056, p = 0.715, l. Correlation between WBC count and spleen volume in NBNC, r = 0.316, p = 0.013.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3755816&req=5

Fig6: Correlations between spleen volumes and each hematological parameter among different etiologies after liver transplantation. a. Correlation between Plt count and spleen volume in HBV, r = 0.617, p < 0.001, b. Correlation between Hb level and spleen volume in HBV, r = 0.401, p < 0.001, c. correlation between WBC count and spleen volume, r = 0.387, p < 0.001, d. Correlation between Plt count and spleen volume in HCV, r = 0.364, p < 0.001, e. Correlation between Hb level and spleen volume in HCV, r = 0.278, p = 0.079, f. Correlation between WBC count and spleen volume in HCV, r = 0.279, p = 0.078, g. Correlation between Plt count and spleen volume in PBC, r = 0.256, p = 0.09, h. Correlation between Hb level and spleen volume in PBC, r = 0.279, p < 0.001, i. Correlation between WBC count and spleen volume in PBC, r = 0.128, p = 0.314, j. Correlation between Plt count and spleen volume in NBNC, r = 0.660, p < 0.001, k. Correlation between Hb level and spleen volume in NBNC, r = 0.056, p = 0.715, l. Correlation between WBC count and spleen volume in NBNC, r = 0.316, p = 0.013.

Mentions: Analysis in each etiology, relatively strong correlations were seen in HBV patients, with the correlations between platelets and spleen volumes the strongest (Plt: r = 0.617, p < 0.001; Figure 6a, Hb: r = 0.401, p < 0.001; Figure 6b, WBC: r = 0.387, p < 0.001; Figure 6c, respectively). In other etiologies, the correlations were generally weak or not significant (Figure 6d-6i, 6k, 6l) except that between Plt level and spleen volume in NBNC (r = 0.660, p < 0.001, Figure 6j).Figure 6


Long-term dynamics of hematological data and spleen volume in cirrhotic patients after liver transplantation-various dynamics depending on etiology.

Ishigami M, Ishizu Y, Onishi Y, Kamei H, Kiuchi T, Itoh A, Hirooka Y, Katano Y, Goto H - Springerplus (2013)

Correlations between spleen volumes and each hematological parameter among different etiologies after liver transplantation. a. Correlation between Plt count and spleen volume in HBV, r = 0.617, p < 0.001, b. Correlation between Hb level and spleen volume in HBV, r = 0.401, p < 0.001, c. correlation between WBC count and spleen volume, r = 0.387, p < 0.001, d. Correlation between Plt count and spleen volume in HCV, r = 0.364, p < 0.001, e. Correlation between Hb level and spleen volume in HCV, r = 0.278, p = 0.079, f. Correlation between WBC count and spleen volume in HCV, r = 0.279, p = 0.078, g. Correlation between Plt count and spleen volume in PBC, r = 0.256, p = 0.09, h. Correlation between Hb level and spleen volume in PBC, r = 0.279, p < 0.001, i. Correlation between WBC count and spleen volume in PBC, r = 0.128, p = 0.314, j. Correlation between Plt count and spleen volume in NBNC, r = 0.660, p < 0.001, k. Correlation between Hb level and spleen volume in NBNC, r = 0.056, p = 0.715, l. Correlation between WBC count and spleen volume in NBNC, r = 0.316, p = 0.013.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3755816&req=5

Fig6: Correlations between spleen volumes and each hematological parameter among different etiologies after liver transplantation. a. Correlation between Plt count and spleen volume in HBV, r = 0.617, p < 0.001, b. Correlation between Hb level and spleen volume in HBV, r = 0.401, p < 0.001, c. correlation between WBC count and spleen volume, r = 0.387, p < 0.001, d. Correlation between Plt count and spleen volume in HCV, r = 0.364, p < 0.001, e. Correlation between Hb level and spleen volume in HCV, r = 0.278, p = 0.079, f. Correlation between WBC count and spleen volume in HCV, r = 0.279, p = 0.078, g. Correlation between Plt count and spleen volume in PBC, r = 0.256, p = 0.09, h. Correlation between Hb level and spleen volume in PBC, r = 0.279, p < 0.001, i. Correlation between WBC count and spleen volume in PBC, r = 0.128, p = 0.314, j. Correlation between Plt count and spleen volume in NBNC, r = 0.660, p < 0.001, k. Correlation between Hb level and spleen volume in NBNC, r = 0.056, p = 0.715, l. Correlation between WBC count and spleen volume in NBNC, r = 0.316, p = 0.013.
Mentions: Analysis in each etiology, relatively strong correlations were seen in HBV patients, with the correlations between platelets and spleen volumes the strongest (Plt: r = 0.617, p < 0.001; Figure 6a, Hb: r = 0.401, p < 0.001; Figure 6b, WBC: r = 0.387, p < 0.001; Figure 6c, respectively). In other etiologies, the correlations were generally weak or not significant (Figure 6d-6i, 6k, 6l) except that between Plt level and spleen volume in NBNC (r = 0.660, p < 0.001, Figure 6j).Figure 6

Bottom Line: However, detailed dynamics, especially over a long term, are not fully understood.We studied 53 cirrhotic patients who underwent liver transplantation at our institute and followed for more than 1 year.Unique dynamics and correlations between them were found among the different etiologies investigated.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology and Hepatology, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550 Nagoya, Japan.

ABSTRACT

Background: Hypersplenism is a common complication in cirrhotic patients, and liver transplantation would be one of the effective treatments. However, detailed dynamics, especially over a long term, are not fully understood. We investigated the long-term dynamics of hematological data and spleen volumes, as well as their correlation in cirrhotic patients who underwent liver transplantation.

Patients and methods: We studied 53 cirrhotic patients who underwent liver transplantation at our institute and followed for more than 1 year. Hematological data were collected from medical records, while spleen volumes were determined by CT volumetry at 0, 1, 3, 6, 12, 24, 36, 48, 60 postoperative months (POM).

Results: (1) Platelet (Plt) and hemoglobin (Hb) levels were gradually increased up to 18 and 10 POM, respectively, in contrast with white blood cells (WBC), which remained mostly unchanged from pretransplantation levels. (2) Spleen volume was sharply decreased in the first POM, then showed a slower but steady decline up to 48 POM. (3) Spleen volume was significantly correlated with hematological data, though the levels were generally weak (Plt: r = 0.433, p < 0.001; Hb: r = 0.233, p < 0.001; WBC: r = 0.217, p = 0.001). (4) Spleen volume was strongly correlated with all hematological parameters in HBV patients (Plt: r = 0.617, p < 0.0001; Hb: r = 0.401, p < 0.001; WBC: r = 0.387, p < 0.001), in contrast with that in other etiologies, which had generally weak correlations though some were statistically significant.

Conclusions: We investigated the long-term dynamics of hematological data and spleen volume in cirrhotic patients after liver transplantation. Unique dynamics and correlations between them were found among the different etiologies investigated.

No MeSH data available.


Related in: MedlinePlus