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Autoimmune diseases and hypersensitivities improve the prognosis in ER-negative breast cancer.

Einefors R, Kogler U, Ellberg C, Olsson H - Springerplus (2013)

Bottom Line: Our main finding was that BC patients with estrogen receptor (ER) negative tumors together with preexisting AD or HS had a statistically significant better overall survival (HR=0.53; 95% CI= 0.30-0.96) compared to patients without.For patients with premenopausal or ER-negative BC, coexistence with AD or HS was associated with a better overall survival.Although these findings require validation, and the mechanisms responsible need to be found, they hint to possible new treatment strategies for BC, especially for those with ER-negative tumors and potentially for premenopausal patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Cancer Epidemiology, Skåne University Hospital Lund, Klinikgatan 22, Lund, 221 85 Sweden ; Department of Cancer Epidemiology, Skåne University Hospital Lund, Klinikgatan 22, Lund, 221 85 Sweden.

ABSTRACT

Introduction: Breast cancer (BC) is one of the leading causes of death among women worldwide. Immunostimulatory treatment has increasingly been used as adjuvant therapy in the last few years, in patients with melanoma and other cancer forms, often with an induction of autoimmunity as a consequence of a successful treatment. We aimed at investigating if coexisting autoimmune diseases (AD) or hypersensitivities (HS) similarly to the side effects of immunostimulatory treatment resulted in a better overall survival, compared to patients without these disorders.

Material and methods: The patient material used was a consecutive clinical material consisting of 1705 patients diagnosed with BC between 1980 and 2010 in Sweden. The patients were stratified according to coexisting AD, HS or lack of both. Overall survival was calculated using Kaplan-Meier and the Cox proportional hazard model.

Results: Our main finding was that BC patients with estrogen receptor (ER) negative tumors together with preexisting AD or HS had a statistically significant better overall survival (HR=0.53; 95% CI= 0.30-0.96) compared to patients without. Premenopausal BC patients with a coexistence of AD or HS had a better overall survival, but this was not statistically significant.

Discussion: For patients with premenopausal or ER-negative BC, coexistence with AD or HS was associated with a better overall survival. Although these findings require validation, and the mechanisms responsible need to be found, they hint to possible new treatment strategies for BC, especially for those with ER-negative tumors and potentially for premenopausal patients.

No MeSH data available.


Related in: MedlinePlus

Survival analysis in BC patients with coexistence of AD or HS stratified based on ER- and menopausal status. Kaplan-Meier analysis on the coexistence of AD or HS stratified based on ER- and menopausal status in; a) patients with ER-negative tumors (dotted line) (N=36), b) patients with ER-positive tumors (dotted line) (N=96), c) premenopausal patients (dotted line) (N=56), and d) postmenopausal patients (dotted line) (N=117) compared to BC patients without (whole line). Log-rank tests were performed individually for each Kaplan-Meier analysis and are presented in each diagram respectively.
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Fig1: Survival analysis in BC patients with coexistence of AD or HS stratified based on ER- and menopausal status. Kaplan-Meier analysis on the coexistence of AD or HS stratified based on ER- and menopausal status in; a) patients with ER-negative tumors (dotted line) (N=36), b) patients with ER-positive tumors (dotted line) (N=96), c) premenopausal patients (dotted line) (N=56), and d) postmenopausal patients (dotted line) (N=117) compared to BC patients without (whole line). Log-rank tests were performed individually for each Kaplan-Meier analysis and are presented in each diagram respectively.

Mentions: Overall survival was estimated using Kaplan-Meier. Stratified analyses were made according to ER-status and menopausal status using the AD-HS group. Patients with ER-negative tumors and AD-HS had a statistically significant better overall survival compared to patients without (Figure 1a). ER-positive cases with AD-HS had a non-statistically significant tendency towards better overall survival (Figure 1b). In premenopausal patients we found a non-statistically significant tendency towards better overall survival (Figure 1c). On the contrary, in postmenopausal patients coexistence of AD or HS did not affect the overall survival (Figure 1d). All three groups (AD-HS, AD, HS) analyzed separately had a tendency towards better overall survival, though none of these results were statistically significant (Figure 2).Figure 1


Autoimmune diseases and hypersensitivities improve the prognosis in ER-negative breast cancer.

Einefors R, Kogler U, Ellberg C, Olsson H - Springerplus (2013)

Survival analysis in BC patients with coexistence of AD or HS stratified based on ER- and menopausal status. Kaplan-Meier analysis on the coexistence of AD or HS stratified based on ER- and menopausal status in; a) patients with ER-negative tumors (dotted line) (N=36), b) patients with ER-positive tumors (dotted line) (N=96), c) premenopausal patients (dotted line) (N=56), and d) postmenopausal patients (dotted line) (N=117) compared to BC patients without (whole line). Log-rank tests were performed individually for each Kaplan-Meier analysis and are presented in each diagram respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3755812&req=5

Fig1: Survival analysis in BC patients with coexistence of AD or HS stratified based on ER- and menopausal status. Kaplan-Meier analysis on the coexistence of AD or HS stratified based on ER- and menopausal status in; a) patients with ER-negative tumors (dotted line) (N=36), b) patients with ER-positive tumors (dotted line) (N=96), c) premenopausal patients (dotted line) (N=56), and d) postmenopausal patients (dotted line) (N=117) compared to BC patients without (whole line). Log-rank tests were performed individually for each Kaplan-Meier analysis and are presented in each diagram respectively.
Mentions: Overall survival was estimated using Kaplan-Meier. Stratified analyses were made according to ER-status and menopausal status using the AD-HS group. Patients with ER-negative tumors and AD-HS had a statistically significant better overall survival compared to patients without (Figure 1a). ER-positive cases with AD-HS had a non-statistically significant tendency towards better overall survival (Figure 1b). In premenopausal patients we found a non-statistically significant tendency towards better overall survival (Figure 1c). On the contrary, in postmenopausal patients coexistence of AD or HS did not affect the overall survival (Figure 1d). All three groups (AD-HS, AD, HS) analyzed separately had a tendency towards better overall survival, though none of these results were statistically significant (Figure 2).Figure 1

Bottom Line: Our main finding was that BC patients with estrogen receptor (ER) negative tumors together with preexisting AD or HS had a statistically significant better overall survival (HR=0.53; 95% CI= 0.30-0.96) compared to patients without.For patients with premenopausal or ER-negative BC, coexistence with AD or HS was associated with a better overall survival.Although these findings require validation, and the mechanisms responsible need to be found, they hint to possible new treatment strategies for BC, especially for those with ER-negative tumors and potentially for premenopausal patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Cancer Epidemiology, Skåne University Hospital Lund, Klinikgatan 22, Lund, 221 85 Sweden ; Department of Cancer Epidemiology, Skåne University Hospital Lund, Klinikgatan 22, Lund, 221 85 Sweden.

ABSTRACT

Introduction: Breast cancer (BC) is one of the leading causes of death among women worldwide. Immunostimulatory treatment has increasingly been used as adjuvant therapy in the last few years, in patients with melanoma and other cancer forms, often with an induction of autoimmunity as a consequence of a successful treatment. We aimed at investigating if coexisting autoimmune diseases (AD) or hypersensitivities (HS) similarly to the side effects of immunostimulatory treatment resulted in a better overall survival, compared to patients without these disorders.

Material and methods: The patient material used was a consecutive clinical material consisting of 1705 patients diagnosed with BC between 1980 and 2010 in Sweden. The patients were stratified according to coexisting AD, HS or lack of both. Overall survival was calculated using Kaplan-Meier and the Cox proportional hazard model.

Results: Our main finding was that BC patients with estrogen receptor (ER) negative tumors together with preexisting AD or HS had a statistically significant better overall survival (HR=0.53; 95% CI= 0.30-0.96) compared to patients without. Premenopausal BC patients with a coexistence of AD or HS had a better overall survival, but this was not statistically significant.

Discussion: For patients with premenopausal or ER-negative BC, coexistence with AD or HS was associated with a better overall survival. Although these findings require validation, and the mechanisms responsible need to be found, they hint to possible new treatment strategies for BC, especially for those with ER-negative tumors and potentially for premenopausal patients.

No MeSH data available.


Related in: MedlinePlus