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Low-dose CT scan screening for lung cancer: comparison of images and radiation doses between low-dose CT and follow-up standard diagnostic CT.

Ono K, Hiraoka T, Ono A, Komatsu E, Shigenaga T, Takaki H, Maeda T, Ogusu H, Yoshida S, Fukushima K, Kai M - Springerplus (2013)

Bottom Line: The concordance rate for the diagnoses was approximately 80% (p < 0.001) for all categories.Agreement of the evaluation of all categories in the final diagnosis exceeded 94% (p < 0.001).This study suggests that low-dose CT can be effectively used as a follow-up standard diagnostic CT in place of standard-dose CT in order to reduce the radiation dose.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Nursing at Higashigaoka, Tokyo Healthcare University, 2-5-1, Higashigaoka, Meguro, Tokyo, Japan.

ABSTRACT

Objectives: This study aim to compare image quality and radiation doses between low-dose CT and follow-up standard diagnostic CT for lung cancer screening.

Methods: In a single medical institution, 19 subjects who had been screened for lung cancer by low-dose CT before going through follow-up standard diagnostic CT were randomly selected. Both CT image sets for all subjects were independently evaluated by five specialized physicians.

Results: There were no significant differences between low-dose CT screening and follow-up standard diagnostic CT for lung cancer screening in all 11 criteria. The concordance rate for the diagnoses was approximately 80% (p < 0.001) for all categories. Agreement of the evaluation of all categories in the final diagnosis exceeded 94% (p < 0.001). Five physicians detecting and characterizing the pulmonary nodules did not recognized the difference between low-dose CT screening and follow-up standard diagnostic CT. With low-dose CT, the effective dose ranged between 1.3 and 3.4 mSv, whereas in the follow-up diagnostic CT, the effective dose ranged between 8.5 and 14.0 mSv.

Conclusion: This study suggests that low-dose CT can be effectively used as a follow-up standard diagnostic CT in place of standard-dose CT in order to reduce the radiation dose.

No MeSH data available.


Related in: MedlinePlus

Low-dose CT screening image and follow-up diagnostic CT image. Low-dose CT screening image with an image slice thickness and interval of 3 mm. Follow-up diagnostic CT image with an image slice thickness and interval of 1 mm. A 46-year-old man with pleural dissemination and adenocarcinoma presenting as a solid nodule with spiculation in the right upper lobe. Results of pathological staging in an operable patient (T4N2M1).
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Fig2: Low-dose CT screening image and follow-up diagnostic CT image. Low-dose CT screening image with an image slice thickness and interval of 3 mm. Follow-up diagnostic CT image with an image slice thickness and interval of 1 mm. A 46-year-old man with pleural dissemination and adenocarcinoma presenting as a solid nodule with spiculation in the right upper lobe. Results of pathological staging in an operable patient (T4N2M1).

Mentions: Evaluation concerning the nodules diagnosed as malignant accorded with the final diagnosis in the subjects. All physicians diagnosed 4 nodules in 3 subjects as malignant or suspected malignancy during follow-up examination. The four malignant nodules included an adenocarcinoma with cavitary lung lesion, pleural dissemination of an adenocarcinoma, and two bronchioloalveolar carcinomas, as shown in Figures 1, 2, 3 and 4. Two patient (3 nodules) diagnoses were confirmed at surgery, and 1 patient was diagnosed with inoperable lung cancer.Figure 1


Low-dose CT scan screening for lung cancer: comparison of images and radiation doses between low-dose CT and follow-up standard diagnostic CT.

Ono K, Hiraoka T, Ono A, Komatsu E, Shigenaga T, Takaki H, Maeda T, Ogusu H, Yoshida S, Fukushima K, Kai M - Springerplus (2013)

Low-dose CT screening image and follow-up diagnostic CT image. Low-dose CT screening image with an image slice thickness and interval of 3 mm. Follow-up diagnostic CT image with an image slice thickness and interval of 1 mm. A 46-year-old man with pleural dissemination and adenocarcinoma presenting as a solid nodule with spiculation in the right upper lobe. Results of pathological staging in an operable patient (T4N2M1).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3755805&req=5

Fig2: Low-dose CT screening image and follow-up diagnostic CT image. Low-dose CT screening image with an image slice thickness and interval of 3 mm. Follow-up diagnostic CT image with an image slice thickness and interval of 1 mm. A 46-year-old man with pleural dissemination and adenocarcinoma presenting as a solid nodule with spiculation in the right upper lobe. Results of pathological staging in an operable patient (T4N2M1).
Mentions: Evaluation concerning the nodules diagnosed as malignant accorded with the final diagnosis in the subjects. All physicians diagnosed 4 nodules in 3 subjects as malignant or suspected malignancy during follow-up examination. The four malignant nodules included an adenocarcinoma with cavitary lung lesion, pleural dissemination of an adenocarcinoma, and two bronchioloalveolar carcinomas, as shown in Figures 1, 2, 3 and 4. Two patient (3 nodules) diagnoses were confirmed at surgery, and 1 patient was diagnosed with inoperable lung cancer.Figure 1

Bottom Line: The concordance rate for the diagnoses was approximately 80% (p < 0.001) for all categories.Agreement of the evaluation of all categories in the final diagnosis exceeded 94% (p < 0.001).This study suggests that low-dose CT can be effectively used as a follow-up standard diagnostic CT in place of standard-dose CT in order to reduce the radiation dose.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Nursing at Higashigaoka, Tokyo Healthcare University, 2-5-1, Higashigaoka, Meguro, Tokyo, Japan.

ABSTRACT

Objectives: This study aim to compare image quality and radiation doses between low-dose CT and follow-up standard diagnostic CT for lung cancer screening.

Methods: In a single medical institution, 19 subjects who had been screened for lung cancer by low-dose CT before going through follow-up standard diagnostic CT were randomly selected. Both CT image sets for all subjects were independently evaluated by five specialized physicians.

Results: There were no significant differences between low-dose CT screening and follow-up standard diagnostic CT for lung cancer screening in all 11 criteria. The concordance rate for the diagnoses was approximately 80% (p < 0.001) for all categories. Agreement of the evaluation of all categories in the final diagnosis exceeded 94% (p < 0.001). Five physicians detecting and characterizing the pulmonary nodules did not recognized the difference between low-dose CT screening and follow-up standard diagnostic CT. With low-dose CT, the effective dose ranged between 1.3 and 3.4 mSv, whereas in the follow-up diagnostic CT, the effective dose ranged between 8.5 and 14.0 mSv.

Conclusion: This study suggests that low-dose CT can be effectively used as a follow-up standard diagnostic CT in place of standard-dose CT in order to reduce the radiation dose.

No MeSH data available.


Related in: MedlinePlus