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Time to relapse and remission of bipolar disorder: findings from a 1-year prospective study in Thailand.

Leelahanaj T, Kongsakon R, Choovanichvong S, Tangwongchai S, Paholpak S, Kongsuk T, Srisurapanont M, Thai Bipolar Registry Study Gro - Neuropsychiatr Dis Treat (2013)

Bottom Line: Using the Kaplan-Meier method, we found that 25% of the participants relapsed in 361 days.About one-fifth of recovered patients had mood relapses within 371 days.On average, a mood episode would remit in 67.5 days.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry and Neurology, Phramongkutklao Hospital, Bangkok, Thailand.

ABSTRACT

Background and methods: This study aimed to determine time to relapse and remission of mood episodes in Thai patients with bipolar disorder (BD). The Thai Bipolar Disorder Registry was a multicenter, prospective, naturalistic, observational study conducted in Thailand. Participants were adult inpatients or outpatients with Diagnostic and Statistical Manual of Mental Disorders bipolar disorder. The diagnosis of bipolar disorder, current psychiatric comorbidity, mood relapse, and mood remission were determined by using the Mini International Neuropsychiatric Interview. Relapse and remission were assessed every 2 months.

Results: Of 424 BD participants, 404 (95.3%) were BD I, and 258 (60.8%) were female. At entry, 260 (61.3%) had recovered, and 49 (11.6%) were recovering. During 1-year follow-up (381.7 person-years), 92 participants (21.7%) had 119 relapses or 0.31 (95% confidence interval 0.25-0.35) episodes per person-year. Among 119 relapses, 58 (48.7%), 39 (32.7%), and 21 (17.6%) of them were depressive, hypomanic, and manic episodes, respectively. Using the Kaplan-Meier method, we found that 25% of the participants relapsed in 361 days. Of the 400 participants who reached remission, 113 (28.2%) had mood relapses. Of 173 mood events accountable for remission analysis, the median time to remission was 67.5 days (72.5 days for depressive episodes versus 58.0 days for manic episodes, log rank P = 0.014).

Conclusions: The 1-year relapse rate in Thai patients with BD was 21.7% or 0.31 episodes per person-year. About one-fifth of recovered patients had mood relapses within 371 days. On average, a mood episode would remit in 67.5 days.

No MeSH data available.


Related in: MedlinePlus

Kaplan–Meier plot for the relapse-survival analysis.
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f1-ndt-9-1249: Kaplan–Meier plot for the relapse-survival analysis.

Mentions: A total of 400 participants who fulfilled the definition of remission status were included in the relapse analysis. Of these, 86 patients (21.5%) had mood relapses within a total observable period of 371 days (the last 86th patient had a mood relapse at 371 days). Using the Kaplan–Meier method, we found that 30.8% of the participants had mood relapses in 371 days, which corresponded to 12.5% in 6 months or 28.2% in 1 year (see Figure 1). Ten percent of them relapsed in 134.5 days (95% CI 64.6–209.0), 20% in 300.8 days (95% CI 237.3–348.2), and 25% in 361 days (95% CI 300.3–>371 days). Because the relapses occurred in less than 50% of the participants, the median time for relapse (days needed for 50% of the participants to have relapses) could not be calculated.


Time to relapse and remission of bipolar disorder: findings from a 1-year prospective study in Thailand.

Leelahanaj T, Kongsakon R, Choovanichvong S, Tangwongchai S, Paholpak S, Kongsuk T, Srisurapanont M, Thai Bipolar Registry Study Gro - Neuropsychiatr Dis Treat (2013)

Kaplan–Meier plot for the relapse-survival analysis.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3755707&req=5

f1-ndt-9-1249: Kaplan–Meier plot for the relapse-survival analysis.
Mentions: A total of 400 participants who fulfilled the definition of remission status were included in the relapse analysis. Of these, 86 patients (21.5%) had mood relapses within a total observable period of 371 days (the last 86th patient had a mood relapse at 371 days). Using the Kaplan–Meier method, we found that 30.8% of the participants had mood relapses in 371 days, which corresponded to 12.5% in 6 months or 28.2% in 1 year (see Figure 1). Ten percent of them relapsed in 134.5 days (95% CI 64.6–209.0), 20% in 300.8 days (95% CI 237.3–348.2), and 25% in 361 days (95% CI 300.3–>371 days). Because the relapses occurred in less than 50% of the participants, the median time for relapse (days needed for 50% of the participants to have relapses) could not be calculated.

Bottom Line: Using the Kaplan-Meier method, we found that 25% of the participants relapsed in 361 days.About one-fifth of recovered patients had mood relapses within 371 days.On average, a mood episode would remit in 67.5 days.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry and Neurology, Phramongkutklao Hospital, Bangkok, Thailand.

ABSTRACT

Background and methods: This study aimed to determine time to relapse and remission of mood episodes in Thai patients with bipolar disorder (BD). The Thai Bipolar Disorder Registry was a multicenter, prospective, naturalistic, observational study conducted in Thailand. Participants were adult inpatients or outpatients with Diagnostic and Statistical Manual of Mental Disorders bipolar disorder. The diagnosis of bipolar disorder, current psychiatric comorbidity, mood relapse, and mood remission were determined by using the Mini International Neuropsychiatric Interview. Relapse and remission were assessed every 2 months.

Results: Of 424 BD participants, 404 (95.3%) were BD I, and 258 (60.8%) were female. At entry, 260 (61.3%) had recovered, and 49 (11.6%) were recovering. During 1-year follow-up (381.7 person-years), 92 participants (21.7%) had 119 relapses or 0.31 (95% confidence interval 0.25-0.35) episodes per person-year. Among 119 relapses, 58 (48.7%), 39 (32.7%), and 21 (17.6%) of them were depressive, hypomanic, and manic episodes, respectively. Using the Kaplan-Meier method, we found that 25% of the participants relapsed in 361 days. Of the 400 participants who reached remission, 113 (28.2%) had mood relapses. Of 173 mood events accountable for remission analysis, the median time to remission was 67.5 days (72.5 days for depressive episodes versus 58.0 days for manic episodes, log rank P = 0.014).

Conclusions: The 1-year relapse rate in Thai patients with BD was 21.7% or 0.31 episodes per person-year. About one-fifth of recovered patients had mood relapses within 371 days. On average, a mood episode would remit in 67.5 days.

No MeSH data available.


Related in: MedlinePlus