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Histiocytic endometritis.

Wader JV, Jain A, Kumbhar SS, Vhawal V - Am J Case Rep (2013)

Bottom Line: We report the case of a 78-year-old post-menopausal female with symptoms of vaginal discharge, fever, and weakness.Radiological investigation showed a mass lesion in the cervix, extending into the myometrium, suggestive of cervical carcinoma.Histopathological examination with extensive sampling of tissue is essential because presence of endometritis does not rule out malignancy.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Krishna Institute of Medical Sciences KIMSU, Karad, Maharashtra, India.

ABSTRACT

Patient: Female, 72 FINAL DIAGNOSIS: Histiocytic endometritis Symptoms: Vaginal discharge • fever • weakness

Medication: - Clinical Procedure: Endometrial and cervical biopsy Specialty: Pathology • Gynaecology.

Objective: Rare disease.

Background: Histiocytic or xanthogranulomatous endometritis, characterized by disappearance of endometrial mucosa and its replacement by sheets of lipid containing histiocytic cells, is very rare. Extensive internet and PubMed searches revealed only 19 cases reported to date. The pathogenesis of histiocytic endometritis seems to be inflammation due to post-menopausal cervical stenosis or as the result of cervical carcinoma. Histiocytic endometritis can infiltrate the myometrium and can mimic a malignancy.

Case report: We report the case of a 78-year-old post-menopausal female with symptoms of vaginal discharge, fever, and weakness. Radiological investigation showed a mass lesion in the cervix, extending into the myometrium, suggestive of cervical carcinoma. The lesion was biopsied and histopathological examination led to the diagnosis of histiocytic endometritis with no evidence of malignancy.

Conclusions: Histiocytic endometritis, an inflammatory pathology, can mimic malignancy clinically as well as radiologically. Histopathological examination with extensive sampling of tissue is essential because presence of endometritis does not rule out malignancy.

No MeSH data available.


Related in: MedlinePlus

Microphotograph showing replacement of endometrial glands with histiocytic sheets with no evidence of malignancy (H&E: 4×).
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f2-amjcaserep-14-329: Microphotograph showing replacement of endometrial glands with histiocytic sheets with no evidence of malignancy (H&E: 4×).

Mentions: Microscopic sections obtained from the tissue received for histopathological examination showed endometrial tissue with few glands and sheets of lipid containing foamy histiocytes in the stroma, along with diffuse infiltration by inflammatory cells (lymphocytes and plasma cells). A few areas of histiocytic aggregates were seen infiltrating the myometrium (Figures 2–5). Ziehl-Neelsen, PAS, and GMS staining revealed no specific organism.


Histiocytic endometritis.

Wader JV, Jain A, Kumbhar SS, Vhawal V - Am J Case Rep (2013)

Microphotograph showing replacement of endometrial glands with histiocytic sheets with no evidence of malignancy (H&E: 4×).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3755699&req=5

f2-amjcaserep-14-329: Microphotograph showing replacement of endometrial glands with histiocytic sheets with no evidence of malignancy (H&E: 4×).
Mentions: Microscopic sections obtained from the tissue received for histopathological examination showed endometrial tissue with few glands and sheets of lipid containing foamy histiocytes in the stroma, along with diffuse infiltration by inflammatory cells (lymphocytes and plasma cells). A few areas of histiocytic aggregates were seen infiltrating the myometrium (Figures 2–5). Ziehl-Neelsen, PAS, and GMS staining revealed no specific organism.

Bottom Line: We report the case of a 78-year-old post-menopausal female with symptoms of vaginal discharge, fever, and weakness.Radiological investigation showed a mass lesion in the cervix, extending into the myometrium, suggestive of cervical carcinoma.Histopathological examination with extensive sampling of tissue is essential because presence of endometritis does not rule out malignancy.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Krishna Institute of Medical Sciences KIMSU, Karad, Maharashtra, India.

ABSTRACT

Patient: Female, 72 FINAL DIAGNOSIS: Histiocytic endometritis Symptoms: Vaginal discharge • fever • weakness

Medication: - Clinical Procedure: Endometrial and cervical biopsy Specialty: Pathology • Gynaecology.

Objective: Rare disease.

Background: Histiocytic or xanthogranulomatous endometritis, characterized by disappearance of endometrial mucosa and its replacement by sheets of lipid containing histiocytic cells, is very rare. Extensive internet and PubMed searches revealed only 19 cases reported to date. The pathogenesis of histiocytic endometritis seems to be inflammation due to post-menopausal cervical stenosis or as the result of cervical carcinoma. Histiocytic endometritis can infiltrate the myometrium and can mimic a malignancy.

Case report: We report the case of a 78-year-old post-menopausal female with symptoms of vaginal discharge, fever, and weakness. Radiological investigation showed a mass lesion in the cervix, extending into the myometrium, suggestive of cervical carcinoma. The lesion was biopsied and histopathological examination led to the diagnosis of histiocytic endometritis with no evidence of malignancy.

Conclusions: Histiocytic endometritis, an inflammatory pathology, can mimic malignancy clinically as well as radiologically. Histopathological examination with extensive sampling of tissue is essential because presence of endometritis does not rule out malignancy.

No MeSH data available.


Related in: MedlinePlus