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Hypoglycemic Effects of Exo-biopolymers Produced by Five Different Medicinal Mushrooms in STZ-induced Diabetic Rats.

Yang BK, Kim GN, Jeong YT, Jeong H, Mehta P, Song CH - Mycobiology (2008)

Bottom Line: Though the hypoglycemic effect was achieved in all the cases, however, C. versicolor EBP proved as the most potent one.The administration of the C. versicolor EBP substantially reduced (29.9%) the plasma glucose level as compared to the saline administered group (control).It also reduced the plasma total cholesterol (TC), triglyceride (TG), aspartate aminotransferase (AST) and, alanine aminotransferase (ALT) levels by 9.22, 23.83, 16.93, and 27.31%, respectively.

View Article: PubMed Central - PubMed

Affiliation: Research Center for Processing & Application of Agricultural Products, Daegu University, Gyungsan, Gyungbuk 712-714, Korea.

ABSTRACT
Hypoglycemic effects of exo-biopolymers (EBP) produced by submerged mycelial cultures of Coriolus versicolor, Cordyceps sinensis, Paecilomyces japonica, Armillariella mellea, and Fomes fomentarius were investigated in streptozotocin (STZ)-induced diabetic rats. The rats from each experimental group were orally administered with EBPs (100 mg/kg BW) daily for 2 weeks. Though the hypoglycemic effect was achieved in all the cases, however, C. versicolor EBP proved as the most potent one. The administration of the C. versicolor EBP substantially reduced (29.9%) the plasma glucose level as compared to the saline administered group (control). It also reduced the plasma total cholesterol (TC), triglyceride (TG), aspartate aminotransferase (AST) and, alanine aminotransferase (ALT) levels by 9.22, 23.83, 16.93, and 27.31%, respectively. The sugar and amino acid compositions of this EBP were also analyzed in detail.

No MeSH data available.


Hypoglycemic effect of exo-biopolymers produced by submerged mycelial culture of different five mushrooms in streptozotocin-induced diabetic rats. 1)See Table 1. Each value is the mean ± S.E. for 9 rats. a,b,cValues with different superscript letters in the same column significantly different among the group at p < 0.05.
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Figure 1: Hypoglycemic effect of exo-biopolymers produced by submerged mycelial culture of different five mushrooms in streptozotocin-induced diabetic rats. 1)See Table 1. Each value is the mean ± S.E. for 9 rats. a,b,cValues with different superscript letters in the same column significantly different among the group at p < 0.05.


Hypoglycemic Effects of Exo-biopolymers Produced by Five Different Medicinal Mushrooms in STZ-induced Diabetic Rats.

Yang BK, Kim GN, Jeong YT, Jeong H, Mehta P, Song CH - Mycobiology (2008)

Hypoglycemic effect of exo-biopolymers produced by submerged mycelial culture of different five mushrooms in streptozotocin-induced diabetic rats. 1)See Table 1. Each value is the mean ± S.E. for 9 rats. a,b,cValues with different superscript letters in the same column significantly different among the group at p < 0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3755251&req=5

Figure 1: Hypoglycemic effect of exo-biopolymers produced by submerged mycelial culture of different five mushrooms in streptozotocin-induced diabetic rats. 1)See Table 1. Each value is the mean ± S.E. for 9 rats. a,b,cValues with different superscript letters in the same column significantly different among the group at p < 0.05.
Bottom Line: Though the hypoglycemic effect was achieved in all the cases, however, C. versicolor EBP proved as the most potent one.The administration of the C. versicolor EBP substantially reduced (29.9%) the plasma glucose level as compared to the saline administered group (control).It also reduced the plasma total cholesterol (TC), triglyceride (TG), aspartate aminotransferase (AST) and, alanine aminotransferase (ALT) levels by 9.22, 23.83, 16.93, and 27.31%, respectively.

View Article: PubMed Central - PubMed

Affiliation: Research Center for Processing & Application of Agricultural Products, Daegu University, Gyungsan, Gyungbuk 712-714, Korea.

ABSTRACT
Hypoglycemic effects of exo-biopolymers (EBP) produced by submerged mycelial cultures of Coriolus versicolor, Cordyceps sinensis, Paecilomyces japonica, Armillariella mellea, and Fomes fomentarius were investigated in streptozotocin (STZ)-induced diabetic rats. The rats from each experimental group were orally administered with EBPs (100 mg/kg BW) daily for 2 weeks. Though the hypoglycemic effect was achieved in all the cases, however, C. versicolor EBP proved as the most potent one. The administration of the C. versicolor EBP substantially reduced (29.9%) the plasma glucose level as compared to the saline administered group (control). It also reduced the plasma total cholesterol (TC), triglyceride (TG), aspartate aminotransferase (AST) and, alanine aminotransferase (ALT) levels by 9.22, 23.83, 16.93, and 27.31%, respectively. The sugar and amino acid compositions of this EBP were also analyzed in detail.

No MeSH data available.