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Antibacterial and Antifungal Studies on Some Schiff Base Complexes of Zinc(II).

Joseyphus RS, Nair MS - Mycobiology (2008)

Bottom Line: A comparative study of inhibition values of the Schiff base ligands and their complexes indicates that the complexes exhibit higher antimicrobial activity than the free ligands.Zinc ions are proven to be essential for the growth-inhibitor effect.The extent of inhibition appeared to be strongly dependent on the initial cell density and on the growth medium.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Manonmaniam Sundaranar University, Tirunelveli-627 012, India.

ABSTRACT
Two Schiff base ligands L1and L2 were obtained by the condensation of glycylglycine respectively with imidazole-2-carboxaldehyde and indole-3-carboxaldehyde and their complexes with Zn(II) were prepared and characterized by microanalytical, conductivity measurement, IR, UV-Vis., XRD and SEM. The molar conductance measurement indicates that the Zn(II) complexes are 1: 1electrolytes. The IR data demonstrate the tetradentate binding of L1and tridentate binding of L2. The XRD data show that Zn(II) complexes with L1and L2 have the crystallite sizes of 53 and 61nm respectively. The surface morphology of the complexes was studied using SEM. The in vitro biological screening effects of the investigated compounds were tested against the bacterial species Staphylococcus aureus, Escherichia coli, Klebsiella pneumaniae, Proteus vulgaris and Pseudomonas aeruginosa and fungal species Aspergillus niger, Rhizopus stolonifer, Aspergillus flavus, Rhizoctonia bataicola and Candida albicans by the disc diffusion method. A comparative study of inhibition values of the Schiff base ligands and their complexes indicates that the complexes exhibit higher antimicrobial activity than the free ligands. Zinc ions are proven to be essential for the growth-inhibitor effect. The extent of inhibition appeared to be strongly dependent on the initial cell density and on the growth medium.

No MeSH data available.


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SEM images of (a) ZnL1 and (b) ZnL2 Schiff base complexes.
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Figure 5: SEM images of (a) ZnL1 and (b) ZnL2 Schiff base complexes.

Mentions: The surface morphology of the Zn(II) complexes in this study are shown in Figs. 5(a) and 5(b). The Zn(II) complex with 5(a) has leaflet morphology, while that with 5(b) has cauliflower like morphology. The particle sizes of the Zn(II) complexes were in the diameter range of few microns. However, particles with sizes less than 100 nm were also observed which groups to form agglomerates of larger size. The smaller grain sizes were found from XRD suggesting that these complexes are polycrystalline with nanosized grains.


Antibacterial and Antifungal Studies on Some Schiff Base Complexes of Zinc(II).

Joseyphus RS, Nair MS - Mycobiology (2008)

SEM images of (a) ZnL1 and (b) ZnL2 Schiff base complexes.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3755241&req=5

Figure 5: SEM images of (a) ZnL1 and (b) ZnL2 Schiff base complexes.
Mentions: The surface morphology of the Zn(II) complexes in this study are shown in Figs. 5(a) and 5(b). The Zn(II) complex with 5(a) has leaflet morphology, while that with 5(b) has cauliflower like morphology. The particle sizes of the Zn(II) complexes were in the diameter range of few microns. However, particles with sizes less than 100 nm were also observed which groups to form agglomerates of larger size. The smaller grain sizes were found from XRD suggesting that these complexes are polycrystalline with nanosized grains.

Bottom Line: A comparative study of inhibition values of the Schiff base ligands and their complexes indicates that the complexes exhibit higher antimicrobial activity than the free ligands.Zinc ions are proven to be essential for the growth-inhibitor effect.The extent of inhibition appeared to be strongly dependent on the initial cell density and on the growth medium.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Manonmaniam Sundaranar University, Tirunelveli-627 012, India.

ABSTRACT
Two Schiff base ligands L1and L2 were obtained by the condensation of glycylglycine respectively with imidazole-2-carboxaldehyde and indole-3-carboxaldehyde and their complexes with Zn(II) were prepared and characterized by microanalytical, conductivity measurement, IR, UV-Vis., XRD and SEM. The molar conductance measurement indicates that the Zn(II) complexes are 1: 1electrolytes. The IR data demonstrate the tetradentate binding of L1and tridentate binding of L2. The XRD data show that Zn(II) complexes with L1and L2 have the crystallite sizes of 53 and 61nm respectively. The surface morphology of the complexes was studied using SEM. The in vitro biological screening effects of the investigated compounds were tested against the bacterial species Staphylococcus aureus, Escherichia coli, Klebsiella pneumaniae, Proteus vulgaris and Pseudomonas aeruginosa and fungal species Aspergillus niger, Rhizopus stolonifer, Aspergillus flavus, Rhizoctonia bataicola and Candida albicans by the disc diffusion method. A comparative study of inhibition values of the Schiff base ligands and their complexes indicates that the complexes exhibit higher antimicrobial activity than the free ligands. Zinc ions are proven to be essential for the growth-inhibitor effect. The extent of inhibition appeared to be strongly dependent on the initial cell density and on the growth medium.

No MeSH data available.


Related in: MedlinePlus