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Antibacterial and Antifungal Studies on Some Schiff Base Complexes of Zinc(II).

Joseyphus RS, Nair MS - Mycobiology (2008)

Bottom Line: A comparative study of inhibition values of the Schiff base ligands and their complexes indicates that the complexes exhibit higher antimicrobial activity than the free ligands.Zinc ions are proven to be essential for the growth-inhibitor effect.The extent of inhibition appeared to be strongly dependent on the initial cell density and on the growth medium.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Manonmaniam Sundaranar University, Tirunelveli-627 012, India.

ABSTRACT
Two Schiff base ligands L1and L2 were obtained by the condensation of glycylglycine respectively with imidazole-2-carboxaldehyde and indole-3-carboxaldehyde and their complexes with Zn(II) were prepared and characterized by microanalytical, conductivity measurement, IR, UV-Vis., XRD and SEM. The molar conductance measurement indicates that the Zn(II) complexes are 1: 1electrolytes. The IR data demonstrate the tetradentate binding of L1and tridentate binding of L2. The XRD data show that Zn(II) complexes with L1and L2 have the crystallite sizes of 53 and 61nm respectively. The surface morphology of the complexes was studied using SEM. The in vitro biological screening effects of the investigated compounds were tested against the bacterial species Staphylococcus aureus, Escherichia coli, Klebsiella pneumaniae, Proteus vulgaris and Pseudomonas aeruginosa and fungal species Aspergillus niger, Rhizopus stolonifer, Aspergillus flavus, Rhizoctonia bataicola and Candida albicans by the disc diffusion method. A comparative study of inhibition values of the Schiff base ligands and their complexes indicates that the complexes exhibit higher antimicrobial activity than the free ligands. Zinc ions are proven to be essential for the growth-inhibitor effect. The extent of inhibition appeared to be strongly dependent on the initial cell density and on the growth medium.

No MeSH data available.


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Proposed structure for ZnL2 Schiff base complex.
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Figure 4: Proposed structure for ZnL2 Schiff base complex.

Mentions: The Schiff base ligands L1 and L2 show the absorption bands at 320 and 307 nm, which is assigned to π-π* transition of the C=N chromophore. On complexation, this band was shifted to lower wavelength region, suggesting the coordination of azomethine nitrogen with Zn(II) ion (Lever, 1984). Zn(II) complex does not exhibit d-d electronic transition due to the completely filled 'd' orbital. Four coordinate Zn(II) complexes would have tetrahedral geometry (Figs. 3 and 4).


Antibacterial and Antifungal Studies on Some Schiff Base Complexes of Zinc(II).

Joseyphus RS, Nair MS - Mycobiology (2008)

Proposed structure for ZnL2 Schiff base complex.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3755241&req=5

Figure 4: Proposed structure for ZnL2 Schiff base complex.
Mentions: The Schiff base ligands L1 and L2 show the absorption bands at 320 and 307 nm, which is assigned to π-π* transition of the C=N chromophore. On complexation, this band was shifted to lower wavelength region, suggesting the coordination of azomethine nitrogen with Zn(II) ion (Lever, 1984). Zn(II) complex does not exhibit d-d electronic transition due to the completely filled 'd' orbital. Four coordinate Zn(II) complexes would have tetrahedral geometry (Figs. 3 and 4).

Bottom Line: A comparative study of inhibition values of the Schiff base ligands and their complexes indicates that the complexes exhibit higher antimicrobial activity than the free ligands.Zinc ions are proven to be essential for the growth-inhibitor effect.The extent of inhibition appeared to be strongly dependent on the initial cell density and on the growth medium.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Manonmaniam Sundaranar University, Tirunelveli-627 012, India.

ABSTRACT
Two Schiff base ligands L1and L2 were obtained by the condensation of glycylglycine respectively with imidazole-2-carboxaldehyde and indole-3-carboxaldehyde and their complexes with Zn(II) were prepared and characterized by microanalytical, conductivity measurement, IR, UV-Vis., XRD and SEM. The molar conductance measurement indicates that the Zn(II) complexes are 1: 1electrolytes. The IR data demonstrate the tetradentate binding of L1and tridentate binding of L2. The XRD data show that Zn(II) complexes with L1and L2 have the crystallite sizes of 53 and 61nm respectively. The surface morphology of the complexes was studied using SEM. The in vitro biological screening effects of the investigated compounds were tested against the bacterial species Staphylococcus aureus, Escherichia coli, Klebsiella pneumaniae, Proteus vulgaris and Pseudomonas aeruginosa and fungal species Aspergillus niger, Rhizopus stolonifer, Aspergillus flavus, Rhizoctonia bataicola and Candida albicans by the disc diffusion method. A comparative study of inhibition values of the Schiff base ligands and their complexes indicates that the complexes exhibit higher antimicrobial activity than the free ligands. Zinc ions are proven to be essential for the growth-inhibitor effect. The extent of inhibition appeared to be strongly dependent on the initial cell density and on the growth medium.

No MeSH data available.


Related in: MedlinePlus