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Anti-tumor Effects of Exo- and Endo-biopolymers Produced from Submerged Cultures of Three Different Mushrooms.

Jeong YT, Yang BK, Li CR, Song CH - Mycobiology (2008)

Bottom Line: The anti-tumor effects of exo- (EX) and endo-biopolymers (EN) produced from submerged mycelial cultures of Ganoderma applanatum (GA), Collybia confluens (CC), and Pleurotus eryngii (PE) were studied using Sarcoma 180 bearing mice.GA-EX and PE-EN reduced the tumor formation by 30.7% and 29.4%, respectively.GA-EX and PE-EN increased the natural killer (NK) cell activity of splenocytes by 41.3% and 28.9%, respectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Biotechnology, Daegu University, Gyeongbuk, Gyeongsan 712-714, Korea.

ABSTRACT
The anti-tumor effects of exo- (EX) and endo-biopolymers (EN) produced from submerged mycelial cultures of Ganoderma applanatum (GA), Collybia confluens (CC), and Pleurotus eryngii (PE) were studied using Sarcoma 180 bearing mice. Solid tumor growth was inhibited most effectively when 40 mg/kg body weight (BW) of GA-EX or PE-EN was administered to the intraperitoneal (i.p.) cavity of BALB/c mice. The spleen and liver indexes were increased in mice following i.p. administration of GA-EX and PE-EN fractions. GA-EX and PE-EN reduced the tumor formation by 30.7% and 29.4%, respectively. GA-EX and PE-EN increased the natural killer (NK) cell activity of splenocytes by 41.3% and 28.9%, respectively.

No MeSH data available.


Related in: MedlinePlus

Effect of exo-biopolymers produced from 3 kinds of mushrooms on the NK cell activity of mice splenic lymphocytes in BALB/c mice 4 weeks after inoculation with Sarcoma 180 cells. Each value is mean ± SE for 10 mice. a,bMeans in the same column with different superscripts are significantly different (p < 0.05). Control: Saline treated control group, GA: Ganoderma applanatum, CC: Collybia confluens, PE: Pleurotus eryngii, EX: Exo-biopolymer.
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Figure 1: Effect of exo-biopolymers produced from 3 kinds of mushrooms on the NK cell activity of mice splenic lymphocytes in BALB/c mice 4 weeks after inoculation with Sarcoma 180 cells. Each value is mean ± SE for 10 mice. a,bMeans in the same column with different superscripts are significantly different (p < 0.05). Control: Saline treated control group, GA: Ganoderma applanatum, CC: Collybia confluens, PE: Pleurotus eryngii, EX: Exo-biopolymer.

Mentions: The effect of EX and EN obtained from 3 different kinds of mushrooms on NK cell activity of mice splenic lymphocytes in Sarcoma 180 cell treated BALB/c mice was shown in Fig. 1 and 2. NK cell activity for all of the EX and EN treated groups was significantly higher than the control group. In particular, GA-EX (86.7%) and PE-EN (87.4%) showed the highest activity when compared with the other EX and EN treated groups. Several investigators have reported that administration of anti-tumor polysaccharides or anti-tumor protein-polysaccharide isolated from mushrooms can restore suppressed NK cell activity in tumor-bearing mice (Moon et al., 1987). NK cell activity plays an important role in the control of tumor growth. NK cells are a subset of lymphocytes that have cytotoxic effects on various malignant cell types and infected cells, playing an important role in the first-line defense against viral disease and cancer (Herberman, 1981; Pedersen, 1985). These results suggest that GA-EX and PE-EN may possess the ability to activate NK cells, promoting tumor killing or reduce tumor growth.


Anti-tumor Effects of Exo- and Endo-biopolymers Produced from Submerged Cultures of Three Different Mushrooms.

Jeong YT, Yang BK, Li CR, Song CH - Mycobiology (2008)

Effect of exo-biopolymers produced from 3 kinds of mushrooms on the NK cell activity of mice splenic lymphocytes in BALB/c mice 4 weeks after inoculation with Sarcoma 180 cells. Each value is mean ± SE for 10 mice. a,bMeans in the same column with different superscripts are significantly different (p < 0.05). Control: Saline treated control group, GA: Ganoderma applanatum, CC: Collybia confluens, PE: Pleurotus eryngii, EX: Exo-biopolymer.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3755232&req=5

Figure 1: Effect of exo-biopolymers produced from 3 kinds of mushrooms on the NK cell activity of mice splenic lymphocytes in BALB/c mice 4 weeks after inoculation with Sarcoma 180 cells. Each value is mean ± SE for 10 mice. a,bMeans in the same column with different superscripts are significantly different (p < 0.05). Control: Saline treated control group, GA: Ganoderma applanatum, CC: Collybia confluens, PE: Pleurotus eryngii, EX: Exo-biopolymer.
Mentions: The effect of EX and EN obtained from 3 different kinds of mushrooms on NK cell activity of mice splenic lymphocytes in Sarcoma 180 cell treated BALB/c mice was shown in Fig. 1 and 2. NK cell activity for all of the EX and EN treated groups was significantly higher than the control group. In particular, GA-EX (86.7%) and PE-EN (87.4%) showed the highest activity when compared with the other EX and EN treated groups. Several investigators have reported that administration of anti-tumor polysaccharides or anti-tumor protein-polysaccharide isolated from mushrooms can restore suppressed NK cell activity in tumor-bearing mice (Moon et al., 1987). NK cell activity plays an important role in the control of tumor growth. NK cells are a subset of lymphocytes that have cytotoxic effects on various malignant cell types and infected cells, playing an important role in the first-line defense against viral disease and cancer (Herberman, 1981; Pedersen, 1985). These results suggest that GA-EX and PE-EN may possess the ability to activate NK cells, promoting tumor killing or reduce tumor growth.

Bottom Line: The anti-tumor effects of exo- (EX) and endo-biopolymers (EN) produced from submerged mycelial cultures of Ganoderma applanatum (GA), Collybia confluens (CC), and Pleurotus eryngii (PE) were studied using Sarcoma 180 bearing mice.GA-EX and PE-EN reduced the tumor formation by 30.7% and 29.4%, respectively.GA-EX and PE-EN increased the natural killer (NK) cell activity of splenocytes by 41.3% and 28.9%, respectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Biotechnology, Daegu University, Gyeongbuk, Gyeongsan 712-714, Korea.

ABSTRACT
The anti-tumor effects of exo- (EX) and endo-biopolymers (EN) produced from submerged mycelial cultures of Ganoderma applanatum (GA), Collybia confluens (CC), and Pleurotus eryngii (PE) were studied using Sarcoma 180 bearing mice. Solid tumor growth was inhibited most effectively when 40 mg/kg body weight (BW) of GA-EX or PE-EN was administered to the intraperitoneal (i.p.) cavity of BALB/c mice. The spleen and liver indexes were increased in mice following i.p. administration of GA-EX and PE-EN fractions. GA-EX and PE-EN reduced the tumor formation by 30.7% and 29.4%, respectively. GA-EX and PE-EN increased the natural killer (NK) cell activity of splenocytes by 41.3% and 28.9%, respectively.

No MeSH data available.


Related in: MedlinePlus