Limits...
Screening and Optimal Extraction of a New Antidementia β-Secretase Inhibitor-Containing Mushroom.

Seo DS, Lee EN, Seo GS, Lee JS - Mycobiology (2008)

Bottom Line: To produce a potent antidementia β-secretase inhibitor from a mushroom, the β-secretase inhibitory activities of various mushroom extracts were determined.Methanol extracts of Lentinula edodes exhibited the highest inhibitory activity (40.1%).The inhibitor was maximally extracted when a fruiting body of L. edodes was treated with 50% methanol at 40℃ for 24 h.

View Article: PubMed Central - PubMed

Affiliation: Department of Life Science and Genetic Engineering, Paichai University, Daejeon 302-735, Korea.

ABSTRACT
To produce a potent antidementia β-secretase inhibitor from a mushroom, the β-secretase inhibitory activities of various mushroom extracts were determined. Methanol extracts of Lentinula edodes exhibited the highest inhibitory activity (40.1%). The inhibitor was maximally extracted when a fruiting body of L. edodes was treated with 50% methanol at 40℃ for 24 h.

No MeSH data available.


Related in: MedlinePlus

Effect of extraction time on extraction of BACE1 inhibitor form Lentinula edodes by methanol at 40℃. ▪: 80% methanol extraction, ♦ 50% methanol extraction.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3755194&req=5

Figure 1: Effect of extraction time on extraction of BACE1 inhibitor form Lentinula edodes by methanol at 40℃. ▪: 80% methanol extraction, ♦ 50% methanol extraction.

Mentions: The time course of the BACE1 inhibitor extraction was determined using 50% and 80% methanol. Inhibitor extraction increased as the extraction time increased. The maximal BACE1 inhibitor extraction levels was obtained by extraction after 24 h (Fig. 1).


Screening and Optimal Extraction of a New Antidementia β-Secretase Inhibitor-Containing Mushroom.

Seo DS, Lee EN, Seo GS, Lee JS - Mycobiology (2008)

Effect of extraction time on extraction of BACE1 inhibitor form Lentinula edodes by methanol at 40℃. ▪: 80% methanol extraction, ♦ 50% methanol extraction.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3755194&req=5

Figure 1: Effect of extraction time on extraction of BACE1 inhibitor form Lentinula edodes by methanol at 40℃. ▪: 80% methanol extraction, ♦ 50% methanol extraction.
Mentions: The time course of the BACE1 inhibitor extraction was determined using 50% and 80% methanol. Inhibitor extraction increased as the extraction time increased. The maximal BACE1 inhibitor extraction levels was obtained by extraction after 24 h (Fig. 1).

Bottom Line: To produce a potent antidementia β-secretase inhibitor from a mushroom, the β-secretase inhibitory activities of various mushroom extracts were determined.Methanol extracts of Lentinula edodes exhibited the highest inhibitory activity (40.1%).The inhibitor was maximally extracted when a fruiting body of L. edodes was treated with 50% methanol at 40℃ for 24 h.

View Article: PubMed Central - PubMed

Affiliation: Department of Life Science and Genetic Engineering, Paichai University, Daejeon 302-735, Korea.

ABSTRACT
To produce a potent antidementia β-secretase inhibitor from a mushroom, the β-secretase inhibitory activities of various mushroom extracts were determined. Methanol extracts of Lentinula edodes exhibited the highest inhibitory activity (40.1%). The inhibitor was maximally extracted when a fruiting body of L. edodes was treated with 50% methanol at 40℃ for 24 h.

No MeSH data available.


Related in: MedlinePlus