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Tumor necrosis factor alpha rs1800629 polymorphism and risk of cervical lesions: a meta-analysis.

Li M, Han Y, Wu TT, Feng Y, Wang HB - PLoS ONE (2013)

Bottom Line: The pooled odds ratios (ORs) with their 95% confidence interval (95%CIs) were calculated to assess the strength of the association.Twenty individual case-control studies from 19 publications with a total of 4,146 cases and 4,731 controls were finally included into the meta-analysis.The meta-analysis suggests that TNF-α rs1800629 polymorphism is associated with increased risk of cervical lesions, especially in Caucasians.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China ; Department of Obstetrics and Gynecology, South Branch of the Six People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.

ABSTRACT

Background: Tumor necrosis factor- alpha (TNF-α) is an inflammatory cytokine which may play important role on the immune response may control the progression of cervical lesions. There is a possible association between TNF-α rs1800629 G/A polymorphism and cervical lesions, but previous studies report conflicting results. We performed a meta-analysis to comprehensively assess the association between TNF-α rs1800629 polymorphism and cervical lesions risk.

Methods: Literature searches of Pubmed, Embase, Web of Science, and Wanfang databases were performed for all publications on the association between TNF-α rs1800629 polymorphism and cervical lesions through December 15, 2012. The pooled odds ratios (ORs) with their 95% confidence interval (95%CIs) were calculated to assess the strength of the association.

Results: Twenty individual case-control studies from 19 publications with a total of 4,146 cases and 4,731 controls were finally included into the meta-analysis. Overall, TNF-α rs1800629 polymorphism was significantly associated with increased risk of cervical lesions under two main genetic comparison models (For A versus G: OR 1.22, 95%CI 1.04-1.44, P = 0.017; for AA versus GG: OR 1.32, 95%CI 1.02-1.71, P = 0.034). Subgroup analysis by ethnicity further showed that there was a significant association between TNF-α rs1800629 polymorphism and increased risk of cervical lesions in Caucasians but not in Asians. Subgroup analysis by the types of cervical lesions showed that there was a significant association between TNF-α rs1800629 polymorphism and increased risk of cervical cancer (For A versus G: OR 1.24, 95%CI 1.05-1.47, P = 0.011; for AA versus GG: OR 1.31, 95%CI 1.01-1.70, P = 0.043; for AA/GA versus GG: OR 1.25, 95%CI 1.01-1.54, P = 0.039).

Conclusion: The meta-analysis suggests that TNF-α rs1800629 polymorphism is associated with increased risk of cervical lesions, especially in Caucasians.

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Related in: MedlinePlus

Funnel plot for the detection of the publication bias in this meta-analysis.
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pone-0069201-g003: Funnel plot for the detection of the publication bias in this meta-analysis.

Mentions: Publication bias was investigated by Begg's funnel plot, and funnel plot asymetry was further assessed by Egger's linear regeression test. As shown in the Figure 3, there was low possibility of asymmetry in the allele comparison model (A versus G) of this meta-analysis (Figure 3). Besides, the Egger linear regression test also suggested there was no significant risk of publication bias (P = 0.532). Therefore, there was no risk of publication bias in the meta-analysis.


Tumor necrosis factor alpha rs1800629 polymorphism and risk of cervical lesions: a meta-analysis.

Li M, Han Y, Wu TT, Feng Y, Wang HB - PLoS ONE (2013)

Funnel plot for the detection of the publication bias in this meta-analysis.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3755002&req=5

pone-0069201-g003: Funnel plot for the detection of the publication bias in this meta-analysis.
Mentions: Publication bias was investigated by Begg's funnel plot, and funnel plot asymetry was further assessed by Egger's linear regeression test. As shown in the Figure 3, there was low possibility of asymmetry in the allele comparison model (A versus G) of this meta-analysis (Figure 3). Besides, the Egger linear regression test also suggested there was no significant risk of publication bias (P = 0.532). Therefore, there was no risk of publication bias in the meta-analysis.

Bottom Line: The pooled odds ratios (ORs) with their 95% confidence interval (95%CIs) were calculated to assess the strength of the association.Twenty individual case-control studies from 19 publications with a total of 4,146 cases and 4,731 controls were finally included into the meta-analysis.The meta-analysis suggests that TNF-α rs1800629 polymorphism is associated with increased risk of cervical lesions, especially in Caucasians.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China ; Department of Obstetrics and Gynecology, South Branch of the Six People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.

ABSTRACT

Background: Tumor necrosis factor- alpha (TNF-α) is an inflammatory cytokine which may play important role on the immune response may control the progression of cervical lesions. There is a possible association between TNF-α rs1800629 G/A polymorphism and cervical lesions, but previous studies report conflicting results. We performed a meta-analysis to comprehensively assess the association between TNF-α rs1800629 polymorphism and cervical lesions risk.

Methods: Literature searches of Pubmed, Embase, Web of Science, and Wanfang databases were performed for all publications on the association between TNF-α rs1800629 polymorphism and cervical lesions through December 15, 2012. The pooled odds ratios (ORs) with their 95% confidence interval (95%CIs) were calculated to assess the strength of the association.

Results: Twenty individual case-control studies from 19 publications with a total of 4,146 cases and 4,731 controls were finally included into the meta-analysis. Overall, TNF-α rs1800629 polymorphism was significantly associated with increased risk of cervical lesions under two main genetic comparison models (For A versus G: OR 1.22, 95%CI 1.04-1.44, P = 0.017; for AA versus GG: OR 1.32, 95%CI 1.02-1.71, P = 0.034). Subgroup analysis by ethnicity further showed that there was a significant association between TNF-α rs1800629 polymorphism and increased risk of cervical lesions in Caucasians but not in Asians. Subgroup analysis by the types of cervical lesions showed that there was a significant association between TNF-α rs1800629 polymorphism and increased risk of cervical cancer (For A versus G: OR 1.24, 95%CI 1.05-1.47, P = 0.011; for AA versus GG: OR 1.31, 95%CI 1.01-1.70, P = 0.043; for AA/GA versus GG: OR 1.25, 95%CI 1.01-1.54, P = 0.039).

Conclusion: The meta-analysis suggests that TNF-α rs1800629 polymorphism is associated with increased risk of cervical lesions, especially in Caucasians.

Show MeSH
Related in: MedlinePlus