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Lobomycosis and squamous cell carcinoma.

Nogueira L, Mendes L, Rodrigues CA, Santos M, Talhari S, Talhari C - An Bras Dermatol (2013 Mar-Apr)

Bottom Line: Malignant transformation may occur on burn scars and chronic ulcers of varying etiology, including infectious agents.Transformation of old lobomycosis lesion scars into squamous cell carcinoma has been rarely reported.Careful and long-term follow-up of such patients is important to avoid carcinomatous transformation.

View Article: PubMed Central - PubMed

Affiliation: Tropical Medicine Foundation of the Amazonas, Manaus, (AM), Brazil.

ABSTRACT
The occurence of squamous cell carcinoma on long-lasting ulcers is classic. Malignant transformation may occur on burn scars and chronic ulcers of varying etiology, including infectious agents. Transformation of old lobomycosis lesion scars into squamous cell carcinoma has been rarely reported. Careful and long-term follow-up of such patients is important to avoid carcinomatous transformation.

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GMS stain showed the typical yeasts of lobomycosis in chains of uniform round tooval cells within the tumoral tissue
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f04: GMS stain showed the typical yeasts of lobomycosis in chains of uniform round tooval cells within the tumoral tissue

Mentions: Histopathological examination of the ulcerated lesion revealed epithelial tumor islands ofvarying size in the dermis. Horn pearls and dyskeratotic cells with hyperchromatic nucleiwere present within the islands. (Figure 3). GMSstain showed the typical yeasts of lobomycosis within the tumoral tissue (Figure 4). Based on clinical and histopathologicalfindings, a diagnosis of squamous cell carcinoma in association to lobomycosis was given.Cranial, chest and abdominal computer scans and inguinal ultra-sound disclosed noabnormalities. The tumoral lesion was excised but the patient was lost to follow-up.


Lobomycosis and squamous cell carcinoma.

Nogueira L, Mendes L, Rodrigues CA, Santos M, Talhari S, Talhari C - An Bras Dermatol (2013 Mar-Apr)

GMS stain showed the typical yeasts of lobomycosis in chains of uniform round tooval cells within the tumoral tissue
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3750902&req=5

f04: GMS stain showed the typical yeasts of lobomycosis in chains of uniform round tooval cells within the tumoral tissue
Mentions: Histopathological examination of the ulcerated lesion revealed epithelial tumor islands ofvarying size in the dermis. Horn pearls and dyskeratotic cells with hyperchromatic nucleiwere present within the islands. (Figure 3). GMSstain showed the typical yeasts of lobomycosis within the tumoral tissue (Figure 4). Based on clinical and histopathologicalfindings, a diagnosis of squamous cell carcinoma in association to lobomycosis was given.Cranial, chest and abdominal computer scans and inguinal ultra-sound disclosed noabnormalities. The tumoral lesion was excised but the patient was lost to follow-up.

Bottom Line: Malignant transformation may occur on burn scars and chronic ulcers of varying etiology, including infectious agents.Transformation of old lobomycosis lesion scars into squamous cell carcinoma has been rarely reported.Careful and long-term follow-up of such patients is important to avoid carcinomatous transformation.

View Article: PubMed Central - PubMed

Affiliation: Tropical Medicine Foundation of the Amazonas, Manaus, (AM), Brazil.

ABSTRACT
The occurence of squamous cell carcinoma on long-lasting ulcers is classic. Malignant transformation may occur on burn scars and chronic ulcers of varying etiology, including infectious agents. Transformation of old lobomycosis lesion scars into squamous cell carcinoma has been rarely reported. Careful and long-term follow-up of such patients is important to avoid carcinomatous transformation.

Show MeSH
Related in: MedlinePlus