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Lobomycosis and squamous cell carcinoma.

Nogueira L, Mendes L, Rodrigues CA, Santos M, Talhari S, Talhari C - An Bras Dermatol (2013 Mar-Apr)

Bottom Line: Malignant transformation may occur on burn scars and chronic ulcers of varying etiology, including infectious agents.Transformation of old lobomycosis lesion scars into squamous cell carcinoma has been rarely reported.Careful and long-term follow-up of such patients is important to avoid carcinomatous transformation.

View Article: PubMed Central - PubMed

Affiliation: Tropical Medicine Foundation of the Amazonas, Manaus, (AM), Brazil.

ABSTRACT
The occurence of squamous cell carcinoma on long-lasting ulcers is classic. Malignant transformation may occur on burn scars and chronic ulcers of varying etiology, including infectious agents. Transformation of old lobomycosis lesion scars into squamous cell carcinoma has been rarely reported. Careful and long-term follow-up of such patients is important to avoid carcinomatous transformation.

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Histopathological examination revealed epithelial tumor islands of varying sizein the dermis. Horn pearls and dyskeratotic cells with hyperchromatic nuclei arepresent within the islands (HE X 20)
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f03: Histopathological examination revealed epithelial tumor islands of varying sizein the dermis. Horn pearls and dyskeratotic cells with hyperchromatic nuclei arepresent within the islands (HE X 20)

Mentions: Histopathological examination of the ulcerated lesion revealed epithelial tumor islands ofvarying size in the dermis. Horn pearls and dyskeratotic cells with hyperchromatic nucleiwere present within the islands. (Figure 3). GMSstain showed the typical yeasts of lobomycosis within the tumoral tissue (Figure 4). Based on clinical and histopathologicalfindings, a diagnosis of squamous cell carcinoma in association to lobomycosis was given.Cranial, chest and abdominal computer scans and inguinal ultra-sound disclosed noabnormalities. The tumoral lesion was excised but the patient was lost to follow-up.


Lobomycosis and squamous cell carcinoma.

Nogueira L, Mendes L, Rodrigues CA, Santos M, Talhari S, Talhari C - An Bras Dermatol (2013 Mar-Apr)

Histopathological examination revealed epithelial tumor islands of varying sizein the dermis. Horn pearls and dyskeratotic cells with hyperchromatic nuclei arepresent within the islands (HE X 20)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3750902&req=5

f03: Histopathological examination revealed epithelial tumor islands of varying sizein the dermis. Horn pearls and dyskeratotic cells with hyperchromatic nuclei arepresent within the islands (HE X 20)
Mentions: Histopathological examination of the ulcerated lesion revealed epithelial tumor islands ofvarying size in the dermis. Horn pearls and dyskeratotic cells with hyperchromatic nucleiwere present within the islands. (Figure 3). GMSstain showed the typical yeasts of lobomycosis within the tumoral tissue (Figure 4). Based on clinical and histopathologicalfindings, a diagnosis of squamous cell carcinoma in association to lobomycosis was given.Cranial, chest and abdominal computer scans and inguinal ultra-sound disclosed noabnormalities. The tumoral lesion was excised but the patient was lost to follow-up.

Bottom Line: Malignant transformation may occur on burn scars and chronic ulcers of varying etiology, including infectious agents.Transformation of old lobomycosis lesion scars into squamous cell carcinoma has been rarely reported.Careful and long-term follow-up of such patients is important to avoid carcinomatous transformation.

View Article: PubMed Central - PubMed

Affiliation: Tropical Medicine Foundation of the Amazonas, Manaus, (AM), Brazil.

ABSTRACT
The occurence of squamous cell carcinoma on long-lasting ulcers is classic. Malignant transformation may occur on burn scars and chronic ulcers of varying etiology, including infectious agents. Transformation of old lobomycosis lesion scars into squamous cell carcinoma has been rarely reported. Careful and long-term follow-up of such patients is important to avoid carcinomatous transformation.

Show MeSH
Related in: MedlinePlus