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Lymphangiectatic Kaposi's sarcoma in a patient with AIDS.

Santos M, Vilasboas V, Mendes L, Talhari C, Talhari S - An Bras Dermatol (2013 Mar-Apr)

Bottom Line: Its four distinct clinical forms are: classic, endemic, iatrogenic and epidemic Kaposi's sarcoma.The clinical course of the disease differs among patients, ranging from a single or a few indolent lesions to an aggressive diffuse disease.Advanced Kaposi's sarcoma lesions, typically those on the lower extremities, are often associated with lymphedema.

View Article: PubMed Central - PubMed

Affiliation: Nilton Lins University – Manaus (AM), Brazil. m.n.souza.santos@gmail.com

ABSTRACT
Kaposi's sarcoma is a malignant disease that originates in the lymphatic endothelium. It has a broad spectrum of clinical manifestations. Its four distinct clinical forms are: classic, endemic, iatrogenic and epidemic Kaposi's sarcoma. In non-HIV-associated Kaposi's sarcoma, the disease is typically limited to the lower extremities, but in immunodeficient patients, it is a multifocal systemic disease. The clinical course of the disease differs among patients, ranging from a single or a few indolent lesions to an aggressive diffuse disease. Advanced Kaposi's sarcoma lesions, typically those on the lower extremities, are often associated with lymphedema. In this paper, we report a case of a patient with a rare form of AIDS-associated Kaposi sarcoma called lymphangiectatic Kaposis's sarcoma.

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Related in: MedlinePlus

Magnetic resonance imaging showed a volumetric increase in the diameter of theentire right thigh associated with severe edema of the entire subcutaneous tissueand a heterogeneous, hypodense area in the proximal right thigh
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f04: Magnetic resonance imaging showed a volumetric increase in the diameter of theentire right thigh associated with severe edema of the entire subcutaneous tissueand a heterogeneous, hypodense area in the proximal right thigh

Mentions: In 2001, a 32-year-old male was referred to the department of dermatology reporting ahistory of lesions in the proximal right thigh. A skin biopsy was performed andsuggested diagnosis of KS. A partial improvement was noted when antiretroviral therapy(TARV) was started, but the patient was lost to follow-up. At diagnosis, CD4+ T-cellcount was 409 cells/mm3 and viral load 76,000 copies/mm3. In 2010, the patient returned with a worsening clinical status, including anincreased number of lesions and edema around the right lower limb. Dermatologicalexamination revealed isolated and confluent erythematousviolaceous tuberous lesions ofvarying sizes as well as a vegetating tumor on the inner right thigh (Figures 1 and 2). Histopathological examination revealed inter-cellular epidermal edema,proliferation of spindle cells, neoangiogenesis and large dilated intratumoral andperitumoral thin-walled lymphatic vessels (Figure3). Magnetic resonance imaging showed a volumetric increase in the diameter ofthe entire right thigh associated with severe edema of the entire subcutaneous tissueand a heterogeneous, hypodense area in the proximal right thigh (Figure 4). Lymphangiocintigraphy revealed bilateral retention of theradiotracer, which was more pronounced in the right lower limb, with signs of lymphaticleakage (Figure 5). CT scan of the skull and chestshowed no abnormalities and the endoscopy was normal. The patient was referred to aspecialized cancer treatment center, where he resumed chemotherapy with paclitaxel, withpartial reduction of edema and lesions.


Lymphangiectatic Kaposi's sarcoma in a patient with AIDS.

Santos M, Vilasboas V, Mendes L, Talhari C, Talhari S - An Bras Dermatol (2013 Mar-Apr)

Magnetic resonance imaging showed a volumetric increase in the diameter of theentire right thigh associated with severe edema of the entire subcutaneous tissueand a heterogeneous, hypodense area in the proximal right thigh
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3750897&req=5

f04: Magnetic resonance imaging showed a volumetric increase in the diameter of theentire right thigh associated with severe edema of the entire subcutaneous tissueand a heterogeneous, hypodense area in the proximal right thigh
Mentions: In 2001, a 32-year-old male was referred to the department of dermatology reporting ahistory of lesions in the proximal right thigh. A skin biopsy was performed andsuggested diagnosis of KS. A partial improvement was noted when antiretroviral therapy(TARV) was started, but the patient was lost to follow-up. At diagnosis, CD4+ T-cellcount was 409 cells/mm3 and viral load 76,000 copies/mm3. In 2010, the patient returned with a worsening clinical status, including anincreased number of lesions and edema around the right lower limb. Dermatologicalexamination revealed isolated and confluent erythematousviolaceous tuberous lesions ofvarying sizes as well as a vegetating tumor on the inner right thigh (Figures 1 and 2). Histopathological examination revealed inter-cellular epidermal edema,proliferation of spindle cells, neoangiogenesis and large dilated intratumoral andperitumoral thin-walled lymphatic vessels (Figure3). Magnetic resonance imaging showed a volumetric increase in the diameter ofthe entire right thigh associated with severe edema of the entire subcutaneous tissueand a heterogeneous, hypodense area in the proximal right thigh (Figure 4). Lymphangiocintigraphy revealed bilateral retention of theradiotracer, which was more pronounced in the right lower limb, with signs of lymphaticleakage (Figure 5). CT scan of the skull and chestshowed no abnormalities and the endoscopy was normal. The patient was referred to aspecialized cancer treatment center, where he resumed chemotherapy with paclitaxel, withpartial reduction of edema and lesions.

Bottom Line: Its four distinct clinical forms are: classic, endemic, iatrogenic and epidemic Kaposi's sarcoma.The clinical course of the disease differs among patients, ranging from a single or a few indolent lesions to an aggressive diffuse disease.Advanced Kaposi's sarcoma lesions, typically those on the lower extremities, are often associated with lymphedema.

View Article: PubMed Central - PubMed

Affiliation: Nilton Lins University – Manaus (AM), Brazil. m.n.souza.santos@gmail.com

ABSTRACT
Kaposi's sarcoma is a malignant disease that originates in the lymphatic endothelium. It has a broad spectrum of clinical manifestations. Its four distinct clinical forms are: classic, endemic, iatrogenic and epidemic Kaposi's sarcoma. In non-HIV-associated Kaposi's sarcoma, the disease is typically limited to the lower extremities, but in immunodeficient patients, it is a multifocal systemic disease. The clinical course of the disease differs among patients, ranging from a single or a few indolent lesions to an aggressive diffuse disease. Advanced Kaposi's sarcoma lesions, typically those on the lower extremities, are often associated with lymphedema. In this paper, we report a case of a patient with a rare form of AIDS-associated Kaposi sarcoma called lymphangiectatic Kaposis's sarcoma.

Show MeSH
Related in: MedlinePlus