Limits...
Non Hodgkin T cell lymphoma: an atypical clinical presentation.

Maio P, Bento D, Vieira R, Afonso A, Sachse F, Kutzner H - An Bras Dermatol (2013 Mar-Apr)

Bottom Line: We describe a 46-year-old man from Cape Verde, with a dermatosis involving his face and trunk, consisting of monomorphic papules with a smooth surface and both motor and sensory polyneuropathy.The hypothesis of leprosy was supported by the clinical and initial hystopathological findings and the patient was referred to our hospital with suspected Hansen's disease.In the new skin and lymph node biopsies a lymphocyte population was identified whose immunohystochemistry study allowed the diagnosis of T-cell lymphoma with expression of cytotoxic markers.The patient was started on chemotherapy with initial remission of the skin lesions but, subsequently, progression of systemic disease.

View Article: PubMed Central - PubMed

Affiliation: Curry Cabral Hospital, Central Lisbon Hospital Center EPE, Lisbon, Portugal. paulamaio@gmail.com

ABSTRACT
Cytotoxic lymphomas comprise a spectrum of peripheral T-cell lymphomas that can have a initial or late cutaneous presentation. We describe a 46-year-old man from Cape Verde, with a dermatosis involving his face and trunk, consisting of monomorphic papules with a smooth surface and both motor and sensory polyneuropathy.The hypothesis of leprosy was supported by the clinical and initial hystopathological findings and the patient was referred to our hospital with suspected Hansen's disease. In the new skin and lymph node biopsies a lymphocyte population was identified whose immunohystochemistry study allowed the diagnosis of T-cell lymphoma with expression of cytotoxic markers. The patient was started on chemotherapy with initial remission of the skin lesions but, subsequently, progression of systemic disease.

Show MeSH

Related in: MedlinePlus

Clinical presentation (left sideof the face). Multiple small monomorphic papulesand plaques slightly infiltrateds
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3750894&req=5

f02: Clinical presentation (left sideof the face). Multiple small monomorphic papulesand plaques slightly infiltrateds

Mentions: We describe a 46-year-old, black male patient, born in Cape Verde. He first noted,months prior to presentation, a dermatosis that almost exclusively involved his face andtrunk consisting of multiple small monomorphic papules with an erythematous smoothsurface. 1,2 The patient reported dysesthesia at the distal ends of both feet andparoxistical difficulty in mobilizing both feet. These symptoms suggested the existenceof a sensory motor polyneuropathy.A cutaneous biopsy was performed motivated by thesefindings. The histopathological evaluation revealed perivascular and periadnexalinflammatory infiltration of nerve bundles with lymphocytic permeation which, withsimultaneous findings of cutaneous involvement and sensory motor polyneuropathy, couldbe consistent with the diagnosis of leprosy. The patient was therefore referred for aconsultation at the hospital regarding the possibility of Hansen's disease. The physicalexamination revealed a dermatosis involving the face and the upper torso that consistedof multiple infracentimetric monomorphic papules and plaques with a smooth erythematoussurface (Figures 1 and 2). There was no hypoesthesia in relation to skin lesions.Examination of ganglionic chains revealed several adenopathies below the chin and inaxillary chains. The adenopathies that were found were over one centimeter in diameter,with a hard consistency. Palpation of the abdomen revealed no masses or organomegaly.


Non Hodgkin T cell lymphoma: an atypical clinical presentation.

Maio P, Bento D, Vieira R, Afonso A, Sachse F, Kutzner H - An Bras Dermatol (2013 Mar-Apr)

Clinical presentation (left sideof the face). Multiple small monomorphic papulesand plaques slightly infiltrateds
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3750894&req=5

f02: Clinical presentation (left sideof the face). Multiple small monomorphic papulesand plaques slightly infiltrateds
Mentions: We describe a 46-year-old, black male patient, born in Cape Verde. He first noted,months prior to presentation, a dermatosis that almost exclusively involved his face andtrunk consisting of multiple small monomorphic papules with an erythematous smoothsurface. 1,2 The patient reported dysesthesia at the distal ends of both feet andparoxistical difficulty in mobilizing both feet. These symptoms suggested the existenceof a sensory motor polyneuropathy.A cutaneous biopsy was performed motivated by thesefindings. The histopathological evaluation revealed perivascular and periadnexalinflammatory infiltration of nerve bundles with lymphocytic permeation which, withsimultaneous findings of cutaneous involvement and sensory motor polyneuropathy, couldbe consistent with the diagnosis of leprosy. The patient was therefore referred for aconsultation at the hospital regarding the possibility of Hansen's disease. The physicalexamination revealed a dermatosis involving the face and the upper torso that consistedof multiple infracentimetric monomorphic papules and plaques with a smooth erythematoussurface (Figures 1 and 2). There was no hypoesthesia in relation to skin lesions.Examination of ganglionic chains revealed several adenopathies below the chin and inaxillary chains. The adenopathies that were found were over one centimeter in diameter,with a hard consistency. Palpation of the abdomen revealed no masses or organomegaly.

Bottom Line: We describe a 46-year-old man from Cape Verde, with a dermatosis involving his face and trunk, consisting of monomorphic papules with a smooth surface and both motor and sensory polyneuropathy.The hypothesis of leprosy was supported by the clinical and initial hystopathological findings and the patient was referred to our hospital with suspected Hansen's disease.In the new skin and lymph node biopsies a lymphocyte population was identified whose immunohystochemistry study allowed the diagnosis of T-cell lymphoma with expression of cytotoxic markers.The patient was started on chemotherapy with initial remission of the skin lesions but, subsequently, progression of systemic disease.

View Article: PubMed Central - PubMed

Affiliation: Curry Cabral Hospital, Central Lisbon Hospital Center EPE, Lisbon, Portugal. paulamaio@gmail.com

ABSTRACT
Cytotoxic lymphomas comprise a spectrum of peripheral T-cell lymphomas that can have a initial or late cutaneous presentation. We describe a 46-year-old man from Cape Verde, with a dermatosis involving his face and trunk, consisting of monomorphic papules with a smooth surface and both motor and sensory polyneuropathy.The hypothesis of leprosy was supported by the clinical and initial hystopathological findings and the patient was referred to our hospital with suspected Hansen's disease. In the new skin and lymph node biopsies a lymphocyte population was identified whose immunohystochemistry study allowed the diagnosis of T-cell lymphoma with expression of cytotoxic markers. The patient was started on chemotherapy with initial remission of the skin lesions but, subsequently, progression of systemic disease.

Show MeSH
Related in: MedlinePlus