Limits...
Prognostic factors affecting the clinical outcome of carcinoma ex pleomorphic adenoma in the major salivary gland.

Zhao J, Wang J, Yu C, Guo L, Wang K, Liang Z, Lou J - World J Surg Oncol (2013)

Bottom Line: Using chi-squared tests, invasiveness, T stage, lymph node involvement and clinical stage were found to be significantly associated with locoregional recurrence.Histological grade, invasiveness, lymph node involvement and perineural invasion were associated with distant metastases (P < 0.05).T stage, lymph node involvement, histological grade, perineural invasion and extent of invasion are important prognostic factors of CXPA in the major salivary glands.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Head and Neck Surgery, Zhejiang Cancer Hospital, 38 Guangji Road, Hangzhou, Zhejiang 310022, China. zhaojianqiang73@163.com

ABSTRACT

Background: Carcinoma ex pleomorphic adenoma (CXPA) is an uncommon malignant tumor with highly aggressive biological behavior. Our goal was to investigate the prognosis of CXPA in the major salivary glands and factors influencing it.

Methods: We retrospectively reviewed 51 patients diagnosed with CXPA of the major salivary glands between 1999 and 2006, comprising 36 males and 15 females, aged from 23 to 86 years. All patients underwent surgery with curative intention, and 21 received postoperative radiation therapy.

Results: Of the 51 patients, 39.2% developed locoregional recurrence and 27.5% developed distant metastases. Median follow-up was 54 months. At the time of analysis, 29 (56.9%) patients were deceased. Overall survival was 62.7% at 3 years and 50.3% at 5 years. Tumor-specific survival was 64.4% at 3 years and 53.5% at 5 years. Using chi-squared tests, invasiveness, T stage, lymph node involvement and clinical stage were found to be significantly associated with locoregional recurrence. Histological grade, invasiveness, lymph node involvement and perineural invasion were associated with distant metastases (P < 0.05). Cox analysis showed that T stage, lymph node involvement, histological grade and perineural invasion were independent prognostic factors for overall survival.

Conclusion: T stage, lymph node involvement, histological grade, perineural invasion and extent of invasion are important prognostic factors of CXPA in the major salivary glands. Surgery is the primary treatment modality for CXPA and postoperative radiation therapy may be used in patients with factors for poor prognosis.

Show MeSH

Related in: MedlinePlus

Survival for all patients. (A) Overall survival. (B) Tumor-specific survival.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3750873&req=5

Figure 1: Survival for all patients. (A) Overall survival. (B) Tumor-specific survival.

Mentions: At the time of the present analysis, 29 (56.9%) patients were dead: 24 patients died from their cancer, while 5 patients died from other causes. Overall survival was 62.7% at 3 years and 50.3% at 5 years. Tumor-specific survival was 64.4% at 3 years and 53.5% at 5 years (Figure 1). In univariate analyses, histological grade (P = 0.02), invasiveness (P = 0.001), T stage (P = 0.002), lymph node involvement (P < 0.001), clinical stage (P < 0.001) and perineural invasion (P < 0.001) were significantly associated with tumor-specific survival. Factors significantly associated with overall survival were age (P = 0.03), histological grade (P = 0.01), invasiveness (P = 0.003), T stage (P = 0.004), lymph node involvement (P < 0.001), clinical stage (P < 0.001) and perineural invasion (P < 0.001) (Table 3). When the seven significantly associated variables in univariate analyses were entered into a Cox model, T stage, lymph node involvement, histological grade and perineural invasion were identified as independent prognostic factors for overall survival (Table 4, Figure 2).


Prognostic factors affecting the clinical outcome of carcinoma ex pleomorphic adenoma in the major salivary gland.

Zhao J, Wang J, Yu C, Guo L, Wang K, Liang Z, Lou J - World J Surg Oncol (2013)

Survival for all patients. (A) Overall survival. (B) Tumor-specific survival.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3750873&req=5

Figure 1: Survival for all patients. (A) Overall survival. (B) Tumor-specific survival.
Mentions: At the time of the present analysis, 29 (56.9%) patients were dead: 24 patients died from their cancer, while 5 patients died from other causes. Overall survival was 62.7% at 3 years and 50.3% at 5 years. Tumor-specific survival was 64.4% at 3 years and 53.5% at 5 years (Figure 1). In univariate analyses, histological grade (P = 0.02), invasiveness (P = 0.001), T stage (P = 0.002), lymph node involvement (P < 0.001), clinical stage (P < 0.001) and perineural invasion (P < 0.001) were significantly associated with tumor-specific survival. Factors significantly associated with overall survival were age (P = 0.03), histological grade (P = 0.01), invasiveness (P = 0.003), T stage (P = 0.004), lymph node involvement (P < 0.001), clinical stage (P < 0.001) and perineural invasion (P < 0.001) (Table 3). When the seven significantly associated variables in univariate analyses were entered into a Cox model, T stage, lymph node involvement, histological grade and perineural invasion were identified as independent prognostic factors for overall survival (Table 4, Figure 2).

Bottom Line: Using chi-squared tests, invasiveness, T stage, lymph node involvement and clinical stage were found to be significantly associated with locoregional recurrence.Histological grade, invasiveness, lymph node involvement and perineural invasion were associated with distant metastases (P < 0.05).T stage, lymph node involvement, histological grade, perineural invasion and extent of invasion are important prognostic factors of CXPA in the major salivary glands.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Head and Neck Surgery, Zhejiang Cancer Hospital, 38 Guangji Road, Hangzhou, Zhejiang 310022, China. zhaojianqiang73@163.com

ABSTRACT

Background: Carcinoma ex pleomorphic adenoma (CXPA) is an uncommon malignant tumor with highly aggressive biological behavior. Our goal was to investigate the prognosis of CXPA in the major salivary glands and factors influencing it.

Methods: We retrospectively reviewed 51 patients diagnosed with CXPA of the major salivary glands between 1999 and 2006, comprising 36 males and 15 females, aged from 23 to 86 years. All patients underwent surgery with curative intention, and 21 received postoperative radiation therapy.

Results: Of the 51 patients, 39.2% developed locoregional recurrence and 27.5% developed distant metastases. Median follow-up was 54 months. At the time of analysis, 29 (56.9%) patients were deceased. Overall survival was 62.7% at 3 years and 50.3% at 5 years. Tumor-specific survival was 64.4% at 3 years and 53.5% at 5 years. Using chi-squared tests, invasiveness, T stage, lymph node involvement and clinical stage were found to be significantly associated with locoregional recurrence. Histological grade, invasiveness, lymph node involvement and perineural invasion were associated with distant metastases (P < 0.05). Cox analysis showed that T stage, lymph node involvement, histological grade and perineural invasion were independent prognostic factors for overall survival.

Conclusion: T stage, lymph node involvement, histological grade, perineural invasion and extent of invasion are important prognostic factors of CXPA in the major salivary glands. Surgery is the primary treatment modality for CXPA and postoperative radiation therapy may be used in patients with factors for poor prognosis.

Show MeSH
Related in: MedlinePlus