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A sparse-projection computed tomography reconstruction method for in vivo application of in-line phase-contrast imaging.

Wang L, Li X, Wu M, Zhang L, Luo S - Biomed Eng Online (2013)

Bottom Line: In recent years, X-ray phase-contrast imaging techniques have been extensively studied to visualize weakly absorbing objects.Combined with computed tomography (CT), phase-contrast CT can produce 3D volumetric images of samples.To date, the most common reconstruction method for phase-contrast X-ray CT imaging has been filtered back projection (FBP).

View Article: PubMed Central - HTML - PubMed

Affiliation: College of Biomedical Engineering, Capital Medical University, You An Men, Beijing 100069, People's Republic of China.

ABSTRACT

Background: In recent years, X-ray phase-contrast imaging techniques have been extensively studied to visualize weakly absorbing objects. One of the most popular methods for phase-contrast imaging is in-line phase-contrast imaging (ILPCI). Combined with computed tomography (CT), phase-contrast CT can produce 3D volumetric images of samples. To date, the most common reconstruction method for phase-contrast X-ray CT imaging has been filtered back projection (FBP). However, because of the impact of respiration, lung slices cannot be reconstructed in vivo for a mouse using this method. Methods for reducing the radiation dose and the sampling time must also be considered.

Methods: This paper proposes a novel method of in vivo mouse lung in-line phase-contrast imaging that has two primary improvements compared with recent methods: 1) using a compressed sensing (CS) theory-based CT reconstruction method for the in vivo in-line phase-contrast imaging application and 2) using the breathing phase extraction method to address the lung and rib cage movement caused by a live mouse's breathing.

Results: Experiments were performed to test the breathing phase extraction method as applied to the lung and rib cage movement of a live mouse. Results with a live mouse specimen demonstrate that our method can reconstruct images of in vivo mouse lung.

Conclusions: The results demonstrate that our method could deal with vivo mouse's breathing and movements, meanwhile, using less sampling data than FBP while maintaining the same high quality.

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Images of two respiratory cycles viewed from one angle.
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Figure 2: Images of two respiratory cycles viewed from one angle.

Mentions: As shown in FigureĀ 2, there are two respiratory cycles in one angle. The aim is to design a respiratory phase extraction algorithm that can divide the images into different phases and extract two stages, expanded to maximum and contracted to minimum. Two parameters, AP (average parameter) and MP (mean parameter), are calculated as


A sparse-projection computed tomography reconstruction method for in vivo application of in-line phase-contrast imaging.

Wang L, Li X, Wu M, Zhang L, Luo S - Biomed Eng Online (2013)

Images of two respiratory cycles viewed from one angle.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3750831&req=5

Figure 2: Images of two respiratory cycles viewed from one angle.
Mentions: As shown in FigureĀ 2, there are two respiratory cycles in one angle. The aim is to design a respiratory phase extraction algorithm that can divide the images into different phases and extract two stages, expanded to maximum and contracted to minimum. Two parameters, AP (average parameter) and MP (mean parameter), are calculated as

Bottom Line: In recent years, X-ray phase-contrast imaging techniques have been extensively studied to visualize weakly absorbing objects.Combined with computed tomography (CT), phase-contrast CT can produce 3D volumetric images of samples.To date, the most common reconstruction method for phase-contrast X-ray CT imaging has been filtered back projection (FBP).

View Article: PubMed Central - HTML - PubMed

Affiliation: College of Biomedical Engineering, Capital Medical University, You An Men, Beijing 100069, People's Republic of China.

ABSTRACT

Background: In recent years, X-ray phase-contrast imaging techniques have been extensively studied to visualize weakly absorbing objects. One of the most popular methods for phase-contrast imaging is in-line phase-contrast imaging (ILPCI). Combined with computed tomography (CT), phase-contrast CT can produce 3D volumetric images of samples. To date, the most common reconstruction method for phase-contrast X-ray CT imaging has been filtered back projection (FBP). However, because of the impact of respiration, lung slices cannot be reconstructed in vivo for a mouse using this method. Methods for reducing the radiation dose and the sampling time must also be considered.

Methods: This paper proposes a novel method of in vivo mouse lung in-line phase-contrast imaging that has two primary improvements compared with recent methods: 1) using a compressed sensing (CS) theory-based CT reconstruction method for the in vivo in-line phase-contrast imaging application and 2) using the breathing phase extraction method to address the lung and rib cage movement caused by a live mouse's breathing.

Results: Experiments were performed to test the breathing phase extraction method as applied to the lung and rib cage movement of a live mouse. Results with a live mouse specimen demonstrate that our method can reconstruct images of in vivo mouse lung.

Conclusions: The results demonstrate that our method could deal with vivo mouse's breathing and movements, meanwhile, using less sampling data than FBP while maintaining the same high quality.

Show MeSH