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Effects of radioiodine administration on serum concentrations of matrix metalloproteinases, adiponectin and thrombospondin-1.

Lewinski A, Brona A, Lewandowski KC, Jedrzejuk D, Bohdanowicz-Pawlak A, Skowronska-Jozwiak E, Bienkiewicz M, Milewicz A - Thyroid Res (2013)

Bottom Line: Further analysis revealed no significant change in MMP-2/TIMP-2 ratio, but there was a significant decrease in MMP-9/TIMP-1 ratio (p < 0.05), suggestive of possible decrease in free MMP-9 concentrations.In contrast, there was no significant change of TSP-1.This might indicate overall safety of radioiodine treatment of thyrotoxicosis in terms of the risks of subsequent cardiovascular and neoplastic disease.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Endocrinology & Metabolic Diseases, Medical University of Lodz, Polish Mother's Memorial Hospital - Research Institute, Rzgowska 281/289, 93-338 Lodz, Poland. alewin@csk.umed.lodz.pl.

ABSTRACT

Background: In order to assess safety of radioactive iodine administration in the treatment of thyrotoxicosis, we measured concentrations of matrix metalloproteinase-2 (MMP-2), its main inhibitor - TIMP-2 (tissue inhibitor of MMP-2), matrix metalloproteinase-9 (MMP-9), its main inhibitor - TIMP-1, adiponectin, as well as pro-inflammatory and procancerogenic thrombospondin-1 (TSP-1).

Design and patients: The study involved 23 patients treated with radioiodine for thyrotoxicosis. Serum concentrations of TSH, free T4, free T3, MMP-2, MMP-9, TIMP-1, TIMP-2, total adiponectin and TSP-1 were measured by immunoassays just before radioiodine administration (visit 1), and subsequently, after 7 days (visit 2), 3 months (visit 3), 6 to 8 months (visit 4) and 15-18 months after radioiodine administration (visit 5).

Results: There were no acute changes in serum concentrations of MMP-2, MMP-9, TIMP-1, TIMP-2, adiponectin and TSP-1 (visit 1 vs. 2). Subsequently, there was an increase in MMP-2 (from 393±106 ng/ml to 774±424 ng/ml), TIMP-1 (from 177±76 ng/ml to 296±118 ng/ml), and adiponectin (from 16442±9490 ng/ml to 23518±9840 ng/ml), visit 1 to 5, respectively (p < 0.01). Further analysis revealed no significant change in MMP-2/TIMP-2 ratio, but there was a significant decrease in MMP-9/TIMP-1 ratio (p < 0.05), suggestive of possible decrease in free MMP-9 concentrations.

Conclusions: Our data reveal a significant and sustained increase in serum adiponectin, as well as possible decrease of free MMP-9 concentration after radioiodine administration. In contrast, there was no significant change of TSP-1. This might indicate overall safety of radioiodine treatment of thyrotoxicosis in terms of the risks of subsequent cardiovascular and neoplastic disease.

No MeSH data available.


Related in: MedlinePlus

Concentrations of adiponectin before and after radioiodine administration at consecutive time-points (visits 1–5), p < 0.01 (Kruskal-Wallis’ ANOVA for repeated measures design).
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Figure 2: Concentrations of adiponectin before and after radioiodine administration at consecutive time-points (visits 1–5), p < 0.01 (Kruskal-Wallis’ ANOVA for repeated measures design).

Mentions: Results of the study are presented in Tables 1, 2 and 3 and Figures 1, 2, 3 and 4. Following radioiodine treatment there was a fall in free T4 between visit 2 and visit 3 (p < 0.01), however, as patients later developing hypothyroidism were treated with L-thyroxine, then the concentrations of free T4 remained stable at subsequent visits. Changes of TSH, free T4, free T3, glucose and lipids at the beginning and at the end of the study are presented in Table 1. Concentrations of other parameters, measured at subsequent visits (1–5) are presented in Table 2. There were no acute changes in serum concentrations of MMP-2, MMP-9, TIMP-1, TIMP-2, adiponectin and TSP-1 (visit 1 vs. visit 2). There was no significant change in serum concentrations of TSP-1 throughout the study (Table 2, Figure 1). In contrast to TSP-1, there was, however, an increase in serum adiponectin (already significant at visit 3, p < 0.05), that remained significant for further duration of the study and (16442±9490 ng/ml at visit 1 (before radioiodine administration) vs. to 23518±9840 ng/ml, at visit 5 (15–18 months after radioiodine administration), p < 0.01, Table 2, Figure 2.


Effects of radioiodine administration on serum concentrations of matrix metalloproteinases, adiponectin and thrombospondin-1.

Lewinski A, Brona A, Lewandowski KC, Jedrzejuk D, Bohdanowicz-Pawlak A, Skowronska-Jozwiak E, Bienkiewicz M, Milewicz A - Thyroid Res (2013)

Concentrations of adiponectin before and after radioiodine administration at consecutive time-points (visits 1–5), p < 0.01 (Kruskal-Wallis’ ANOVA for repeated measures design).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3750645&req=5

Figure 2: Concentrations of adiponectin before and after radioiodine administration at consecutive time-points (visits 1–5), p < 0.01 (Kruskal-Wallis’ ANOVA for repeated measures design).
Mentions: Results of the study are presented in Tables 1, 2 and 3 and Figures 1, 2, 3 and 4. Following radioiodine treatment there was a fall in free T4 between visit 2 and visit 3 (p < 0.01), however, as patients later developing hypothyroidism were treated with L-thyroxine, then the concentrations of free T4 remained stable at subsequent visits. Changes of TSH, free T4, free T3, glucose and lipids at the beginning and at the end of the study are presented in Table 1. Concentrations of other parameters, measured at subsequent visits (1–5) are presented in Table 2. There were no acute changes in serum concentrations of MMP-2, MMP-9, TIMP-1, TIMP-2, adiponectin and TSP-1 (visit 1 vs. visit 2). There was no significant change in serum concentrations of TSP-1 throughout the study (Table 2, Figure 1). In contrast to TSP-1, there was, however, an increase in serum adiponectin (already significant at visit 3, p < 0.05), that remained significant for further duration of the study and (16442±9490 ng/ml at visit 1 (before radioiodine administration) vs. to 23518±9840 ng/ml, at visit 5 (15–18 months after radioiodine administration), p < 0.01, Table 2, Figure 2.

Bottom Line: Further analysis revealed no significant change in MMP-2/TIMP-2 ratio, but there was a significant decrease in MMP-9/TIMP-1 ratio (p < 0.05), suggestive of possible decrease in free MMP-9 concentrations.In contrast, there was no significant change of TSP-1.This might indicate overall safety of radioiodine treatment of thyrotoxicosis in terms of the risks of subsequent cardiovascular and neoplastic disease.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Endocrinology & Metabolic Diseases, Medical University of Lodz, Polish Mother's Memorial Hospital - Research Institute, Rzgowska 281/289, 93-338 Lodz, Poland. alewin@csk.umed.lodz.pl.

ABSTRACT

Background: In order to assess safety of radioactive iodine administration in the treatment of thyrotoxicosis, we measured concentrations of matrix metalloproteinase-2 (MMP-2), its main inhibitor - TIMP-2 (tissue inhibitor of MMP-2), matrix metalloproteinase-9 (MMP-9), its main inhibitor - TIMP-1, adiponectin, as well as pro-inflammatory and procancerogenic thrombospondin-1 (TSP-1).

Design and patients: The study involved 23 patients treated with radioiodine for thyrotoxicosis. Serum concentrations of TSH, free T4, free T3, MMP-2, MMP-9, TIMP-1, TIMP-2, total adiponectin and TSP-1 were measured by immunoassays just before radioiodine administration (visit 1), and subsequently, after 7 days (visit 2), 3 months (visit 3), 6 to 8 months (visit 4) and 15-18 months after radioiodine administration (visit 5).

Results: There were no acute changes in serum concentrations of MMP-2, MMP-9, TIMP-1, TIMP-2, adiponectin and TSP-1 (visit 1 vs. 2). Subsequently, there was an increase in MMP-2 (from 393±106 ng/ml to 774±424 ng/ml), TIMP-1 (from 177±76 ng/ml to 296±118 ng/ml), and adiponectin (from 16442±9490 ng/ml to 23518±9840 ng/ml), visit 1 to 5, respectively (p < 0.01). Further analysis revealed no significant change in MMP-2/TIMP-2 ratio, but there was a significant decrease in MMP-9/TIMP-1 ratio (p < 0.05), suggestive of possible decrease in free MMP-9 concentrations.

Conclusions: Our data reveal a significant and sustained increase in serum adiponectin, as well as possible decrease of free MMP-9 concentration after radioiodine administration. In contrast, there was no significant change of TSP-1. This might indicate overall safety of radioiodine treatment of thyrotoxicosis in terms of the risks of subsequent cardiovascular and neoplastic disease.

No MeSH data available.


Related in: MedlinePlus