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Changing trends and serotype distribution of Shigella species in Beijing from 1994 to 2010.

Mao Y, Cui E, Bao C, Liu Z, Chen S, Zhang J, Wang H, Zhang C, Zou J, Klena JD, Zhu B, Qu F, Wang Z - Gut Pathog (2013)

Bottom Line: The annual number of Shigella isolates reached a peak (n = 1192; 19.84%) in 1996 and then decreased annually, reaching the lowest point (n = 24; 0.41%) in 2010.Significant decreases in percentage of S. flexneri over time were observed.Continuous monitoring of Shigella showed that all 4 species and 27 serotypes were present in Beijing, China, during the study period.

View Article: PubMed Central - HTML - PubMed

Affiliation: Clinical Diagnostic Center, 302nd Hospital of the People's Liberation Army, Beijing 100039, PR China.

ABSTRACT
Shigella species are a common cause of acute diarrheal disease in China. In this study, we characterized the changing trends and serotype distribution of Shigella species in Beijing from 1994 to 2010. A total of 5999 Shigella strains were isolated and serotyped from the 302nd Hospital in Beijing. The annual number of Shigella isolates reached a peak (n = 1192; 19.84%) in 1996 and then decreased annually, reaching the lowest point (n = 24; 0.41%) in 2010. S. flexneri 2a and S. sonnei were the most frequently isolated Shigella, with their respective isolates making up 53.3% and 27.6% of the total. Isolates of S. flexneri 4c, 4a, and x made up 3% respectively of the total isolates. Significant decreases in percentage of S. flexneri over time were observed. S. sonnei surpassed S. flexneri 2a as the predominant serotype in 2000. Most isolates were recovered from July to September; 13.6% of the isolates were recovered from children aged 0 to 5 years, and 16% were recovered from those aged 21 to 25 years. S. flexneri 2a and 5 were recovered mostly from males (33.41%, p < 0.001; and 0.46%, p < 0.001%; respectively), whereas S. flexneri 2b and 6, and S. sonnei were most often isolated from females. Continuous monitoring of Shigella showed that all 4 species and 27 serotypes were present in Beijing, China, during the study period. The emergence of S. sonnei and the overall decreasing isolation rate of Shigella in Beijing can potentially aid in the development of vaccine and control strategies for shigellosis in the city.

No MeSH data available.


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Isolation rates of Shigella spp. by subgroup in Beijing from 1994 to 2010.
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Figure 4: Isolation rates of Shigella spp. by subgroup in Beijing from 1994 to 2010.

Mentions: The distribution of typeable Shigella during the study period was S. flexneri, 71.7% (n = 4295); S. sonnei, 27.3% (n = 1639); S. dysenteriae, 0.55% (n = 33); and S. boydii, 0.33% (n = 20). The distribution of Shigella species changed over the 17-year observation period (Figure 4). Between 1994 and 2005, Shigella isolation rates were largely driven by S. flexneri, reaching peak numbers in 1996 when 90% of all isolated Shigella were S. flexneri. In 2006, S. sonnei became the dominant subgroup. In 2009, the lowest percentage of isolated S. flexneri (6%) was recorded. The apparent isolation rates of S. boydii and S. dysenteriae increased during this period, e.g., S. boydii isolation rates increased from 0% to 4.2% (n = 5), 3.8% (n = 3), 4.5% (n = 1), 8.3% (n = 3), and 7.6% (n = 2) in 2006, 2007, 2008, 2009, and 2010, respectively. However, the absolute numbers of S. boydii and S. dysenteriae did not change during this period, remaining between 0 and 5 per year. This result suggests that although uncommon, sources of S. dysenteriae and S. boydii remain in the Beijing area.


Changing trends and serotype distribution of Shigella species in Beijing from 1994 to 2010.

Mao Y, Cui E, Bao C, Liu Z, Chen S, Zhang J, Wang H, Zhang C, Zou J, Klena JD, Zhu B, Qu F, Wang Z - Gut Pathog (2013)

Isolation rates of Shigella spp. by subgroup in Beijing from 1994 to 2010.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3750644&req=5

Figure 4: Isolation rates of Shigella spp. by subgroup in Beijing from 1994 to 2010.
Mentions: The distribution of typeable Shigella during the study period was S. flexneri, 71.7% (n = 4295); S. sonnei, 27.3% (n = 1639); S. dysenteriae, 0.55% (n = 33); and S. boydii, 0.33% (n = 20). The distribution of Shigella species changed over the 17-year observation period (Figure 4). Between 1994 and 2005, Shigella isolation rates were largely driven by S. flexneri, reaching peak numbers in 1996 when 90% of all isolated Shigella were S. flexneri. In 2006, S. sonnei became the dominant subgroup. In 2009, the lowest percentage of isolated S. flexneri (6%) was recorded. The apparent isolation rates of S. boydii and S. dysenteriae increased during this period, e.g., S. boydii isolation rates increased from 0% to 4.2% (n = 5), 3.8% (n = 3), 4.5% (n = 1), 8.3% (n = 3), and 7.6% (n = 2) in 2006, 2007, 2008, 2009, and 2010, respectively. However, the absolute numbers of S. boydii and S. dysenteriae did not change during this period, remaining between 0 and 5 per year. This result suggests that although uncommon, sources of S. dysenteriae and S. boydii remain in the Beijing area.

Bottom Line: The annual number of Shigella isolates reached a peak (n = 1192; 19.84%) in 1996 and then decreased annually, reaching the lowest point (n = 24; 0.41%) in 2010.Significant decreases in percentage of S. flexneri over time were observed.Continuous monitoring of Shigella showed that all 4 species and 27 serotypes were present in Beijing, China, during the study period.

View Article: PubMed Central - HTML - PubMed

Affiliation: Clinical Diagnostic Center, 302nd Hospital of the People's Liberation Army, Beijing 100039, PR China.

ABSTRACT
Shigella species are a common cause of acute diarrheal disease in China. In this study, we characterized the changing trends and serotype distribution of Shigella species in Beijing from 1994 to 2010. A total of 5999 Shigella strains were isolated and serotyped from the 302nd Hospital in Beijing. The annual number of Shigella isolates reached a peak (n = 1192; 19.84%) in 1996 and then decreased annually, reaching the lowest point (n = 24; 0.41%) in 2010. S. flexneri 2a and S. sonnei were the most frequently isolated Shigella, with their respective isolates making up 53.3% and 27.6% of the total. Isolates of S. flexneri 4c, 4a, and x made up 3% respectively of the total isolates. Significant decreases in percentage of S. flexneri over time were observed. S. sonnei surpassed S. flexneri 2a as the predominant serotype in 2000. Most isolates were recovered from July to September; 13.6% of the isolates were recovered from children aged 0 to 5 years, and 16% were recovered from those aged 21 to 25 years. S. flexneri 2a and 5 were recovered mostly from males (33.41%, p < 0.001; and 0.46%, p < 0.001%; respectively), whereas S. flexneri 2b and 6, and S. sonnei were most often isolated from females. Continuous monitoring of Shigella showed that all 4 species and 27 serotypes were present in Beijing, China, during the study period. The emergence of S. sonnei and the overall decreasing isolation rate of Shigella in Beijing can potentially aid in the development of vaccine and control strategies for shigellosis in the city.

No MeSH data available.


Related in: MedlinePlus