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Changing trends and serotype distribution of Shigella species in Beijing from 1994 to 2010.

Mao Y, Cui E, Bao C, Liu Z, Chen S, Zhang J, Wang H, Zhang C, Zou J, Klena JD, Zhu B, Qu F, Wang Z - Gut Pathog (2013)

Bottom Line: The annual number of Shigella isolates reached a peak (n = 1192; 19.84%) in 1996 and then decreased annually, reaching the lowest point (n = 24; 0.41%) in 2010.Significant decreases in percentage of S. flexneri over time were observed.Continuous monitoring of Shigella showed that all 4 species and 27 serotypes were present in Beijing, China, during the study period.

View Article: PubMed Central - HTML - PubMed

Affiliation: Clinical Diagnostic Center, 302nd Hospital of the People's Liberation Army, Beijing 100039, PR China.

ABSTRACT
Shigella species are a common cause of acute diarrheal disease in China. In this study, we characterized the changing trends and serotype distribution of Shigella species in Beijing from 1994 to 2010. A total of 5999 Shigella strains were isolated and serotyped from the 302nd Hospital in Beijing. The annual number of Shigella isolates reached a peak (n = 1192; 19.84%) in 1996 and then decreased annually, reaching the lowest point (n = 24; 0.41%) in 2010. S. flexneri 2a and S. sonnei were the most frequently isolated Shigella, with their respective isolates making up 53.3% and 27.6% of the total. Isolates of S. flexneri 4c, 4a, and x made up 3% respectively of the total isolates. Significant decreases in percentage of S. flexneri over time were observed. S. sonnei surpassed S. flexneri 2a as the predominant serotype in 2000. Most isolates were recovered from July to September; 13.6% of the isolates were recovered from children aged 0 to 5 years, and 16% were recovered from those aged 21 to 25 years. S. flexneri 2a and 5 were recovered mostly from males (33.41%, p < 0.001; and 0.46%, p < 0.001%; respectively), whereas S. flexneri 2b and 6, and S. sonnei were most often isolated from females. Continuous monitoring of Shigella showed that all 4 species and 27 serotypes were present in Beijing, China, during the study period. The emergence of S. sonnei and the overall decreasing isolation rate of Shigella in Beijing can potentially aid in the development of vaccine and control strategies for shigellosis in the city.

No MeSH data available.


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Trends over time for Shigella spp. isolated from Beijing between 1994 and 2010.
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Figure 2: Trends over time for Shigella spp. isolated from Beijing between 1994 and 2010.

Mentions: A statistically significant decreasing trend in S. flexneri and an increasing trend in S. sonnei were observed by chi-square analysis (p < 0.01) (Figure 1). The trends in Shigella spp. isolated from Beijing between 1994 and 2010 are shown in Figure 2. The recording of annual Shigella isolation began in 1994, and the maximum number of isolates was reported in 1996 (n = 1194). The annual total number of isolated Shigella organisms had been decreasing since then, reaching a low point in 2008 (n = 22). This trend may be related to the strict hygiene inspection and adequate sanitation during the 2008 Olympic season [17]. Four peaks were observed during the 17-year collection period. Peak 1 appeared in 1996, with subsequent peaks in 1998 (peak 2, n = 602), 2002 (peak 3, n = 398), and 2004 (peak 4, n = 251). A sudden decrease in Shigella isolation was observed more in 2003 than in 2002 and 2004; one possible explanation is that resources were redirected to identify severe acute respiratory syndrome cases in China in 2003, thereby limiting bacterial diarrheal isolation. It should be noted that as the numbers of observed cases of shigellosis were decreasing, China’s per capita gross domestic product (GDP) was increasing (Figure 3).


Changing trends and serotype distribution of Shigella species in Beijing from 1994 to 2010.

Mao Y, Cui E, Bao C, Liu Z, Chen S, Zhang J, Wang H, Zhang C, Zou J, Klena JD, Zhu B, Qu F, Wang Z - Gut Pathog (2013)

Trends over time for Shigella spp. isolated from Beijing between 1994 and 2010.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3750644&req=5

Figure 2: Trends over time for Shigella spp. isolated from Beijing between 1994 and 2010.
Mentions: A statistically significant decreasing trend in S. flexneri and an increasing trend in S. sonnei were observed by chi-square analysis (p < 0.01) (Figure 1). The trends in Shigella spp. isolated from Beijing between 1994 and 2010 are shown in Figure 2. The recording of annual Shigella isolation began in 1994, and the maximum number of isolates was reported in 1996 (n = 1194). The annual total number of isolated Shigella organisms had been decreasing since then, reaching a low point in 2008 (n = 22). This trend may be related to the strict hygiene inspection and adequate sanitation during the 2008 Olympic season [17]. Four peaks were observed during the 17-year collection period. Peak 1 appeared in 1996, with subsequent peaks in 1998 (peak 2, n = 602), 2002 (peak 3, n = 398), and 2004 (peak 4, n = 251). A sudden decrease in Shigella isolation was observed more in 2003 than in 2002 and 2004; one possible explanation is that resources were redirected to identify severe acute respiratory syndrome cases in China in 2003, thereby limiting bacterial diarrheal isolation. It should be noted that as the numbers of observed cases of shigellosis were decreasing, China’s per capita gross domestic product (GDP) was increasing (Figure 3).

Bottom Line: The annual number of Shigella isolates reached a peak (n = 1192; 19.84%) in 1996 and then decreased annually, reaching the lowest point (n = 24; 0.41%) in 2010.Significant decreases in percentage of S. flexneri over time were observed.Continuous monitoring of Shigella showed that all 4 species and 27 serotypes were present in Beijing, China, during the study period.

View Article: PubMed Central - HTML - PubMed

Affiliation: Clinical Diagnostic Center, 302nd Hospital of the People's Liberation Army, Beijing 100039, PR China.

ABSTRACT
Shigella species are a common cause of acute diarrheal disease in China. In this study, we characterized the changing trends and serotype distribution of Shigella species in Beijing from 1994 to 2010. A total of 5999 Shigella strains were isolated and serotyped from the 302nd Hospital in Beijing. The annual number of Shigella isolates reached a peak (n = 1192; 19.84%) in 1996 and then decreased annually, reaching the lowest point (n = 24; 0.41%) in 2010. S. flexneri 2a and S. sonnei were the most frequently isolated Shigella, with their respective isolates making up 53.3% and 27.6% of the total. Isolates of S. flexneri 4c, 4a, and x made up 3% respectively of the total isolates. Significant decreases in percentage of S. flexneri over time were observed. S. sonnei surpassed S. flexneri 2a as the predominant serotype in 2000. Most isolates were recovered from July to September; 13.6% of the isolates were recovered from children aged 0 to 5 years, and 16% were recovered from those aged 21 to 25 years. S. flexneri 2a and 5 were recovered mostly from males (33.41%, p < 0.001; and 0.46%, p < 0.001%; respectively), whereas S. flexneri 2b and 6, and S. sonnei were most often isolated from females. Continuous monitoring of Shigella showed that all 4 species and 27 serotypes were present in Beijing, China, during the study period. The emergence of S. sonnei and the overall decreasing isolation rate of Shigella in Beijing can potentially aid in the development of vaccine and control strategies for shigellosis in the city.

No MeSH data available.


Related in: MedlinePlus