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Synthesis, solvatochromism and crystal structure of 5-Methoxy-5,6-diphenyl-4,5-dihydro-2H -1,2,4-triazine-3-thione.

Rezaei B, Fazlollahi M - Chem Cent J (2013)

Bottom Line: It was found that the monomer of the ligand 5-Methoxy-5,6-diphenyl-4,5-dihydro-2H-1,2,4-triazine-3-thione, further extends into 3D networks via hydrogen bonding and pi-pi stacking interactions.While progressing from the non-polar solvent to the polar one, the main intense band at 310 nm, which is due to the π-π* transition, was red shifted by 13 nm.Thus, the title compound showed positive solvatochromic behavior.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Chemistry, Lorestan University, Khorramabad, Iran.

ABSTRACT

Background: For the development of properties in molecular crystals, such as electrical conductivities, magnetic properties, or non-linear optical properties, not only the electronic properties of molecules themselves matter, but also the molecular arrangements in the crystals are very important. Therefore, the design of the crystal structures and the control of molecular arrangements have attracted much attention in recent years. Among various ligands, triazine moieties have been especially interesting because of their biological, pharmacological and medicinal properties.

Results: Crystal structure of 5-Methoxy-5,6-diphenyl-4,5-dihydro-2H-1,2,4-triazine-3-thione is Monoclinic, which consists of space group P21/c with a = 9.699(1), b = 8.500(1), c = 18.044(2) Å, β = 101.290(7)° and Z = 4, R1 = 0.0371 and wR2 = 0.1008 with 2456 reflections (I > 2σ(I)). Intermolecular H bonds between NH groups are acting as donors and S atoms as acceptors. There are also shorted face-to-face as well as edge to face π-π stacking interactions between the parallel aromatic rings. The behavior of solvatochromic of the mentioned compound that involved interhydrogen bonding was investigated by studying its electronic absorption spectra in pure organic solvents of different characters.

Conclusions: The crystal structure of C16H15N3OS, shows the expected face-to-face π-π stacking interactions between aromatic rings of the neighbor chains in this compound. The centroid-centroid distance between the aromatic rings is 3.325 Å. It was found that the monomer of the ligand 5-Methoxy-5,6-diphenyl-4,5-dihydro-2H-1,2,4-triazine-3-thione, further extends into 3D networks via hydrogen bonding and pi-pi stacking interactions. The solvatochromic behavior of the title compound was also investigated by studying its spectra in a selection of different organic solvents. While progressing from the non-polar solvent to the polar one, the main intense band at 310 nm, which is due to the π-π* transition, was red shifted by 13 nm. Thus, the title compound showed positive solvatochromic behavior.

No MeSH data available.


Related in: MedlinePlus

Chemical structure of 5-Methoxy-5,6-diphenyl-4,5-dihydro-2H-1,2,4-triazine-3-thione.
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Figure 1: Chemical structure of 5-Methoxy-5,6-diphenyl-4,5-dihydro-2H-1,2,4-triazine-3-thione.

Mentions: Numerous compounds containing the 1,2,4-triazine moieties are well known in natural materials and show interesting biological, pharmacological and medicinal properties. One of the important classes of N-containing heterocycles is the 3,5,6-trisubstituted-1,2,4-triazines. Some of them can be active as blood platelet aggregation inhibitors and others exhibit antiviral inhibitory activity (against influenza viruses for example), significant activity towards leukaemia and ovarian cancer, and anti-HIV activity [1-4]. Therefore, the design of molecule structures and control of molecular arrangements have attracted much attention in recent years [5]. In this paper, we wish to report the crystalline structure of 5-Methoxy-5,6-diphenyl-4,5-dihydro-2H-1,2,4-triazine-3-thione (Figure 1). In addition to structural, solvatochromic properties of the mentioned molecule are discussed.


Synthesis, solvatochromism and crystal structure of 5-Methoxy-5,6-diphenyl-4,5-dihydro-2H -1,2,4-triazine-3-thione.

Rezaei B, Fazlollahi M - Chem Cent J (2013)

Chemical structure of 5-Methoxy-5,6-diphenyl-4,5-dihydro-2H-1,2,4-triazine-3-thione.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3750551&req=5

Figure 1: Chemical structure of 5-Methoxy-5,6-diphenyl-4,5-dihydro-2H-1,2,4-triazine-3-thione.
Mentions: Numerous compounds containing the 1,2,4-triazine moieties are well known in natural materials and show interesting biological, pharmacological and medicinal properties. One of the important classes of N-containing heterocycles is the 3,5,6-trisubstituted-1,2,4-triazines. Some of them can be active as blood platelet aggregation inhibitors and others exhibit antiviral inhibitory activity (against influenza viruses for example), significant activity towards leukaemia and ovarian cancer, and anti-HIV activity [1-4]. Therefore, the design of molecule structures and control of molecular arrangements have attracted much attention in recent years [5]. In this paper, we wish to report the crystalline structure of 5-Methoxy-5,6-diphenyl-4,5-dihydro-2H-1,2,4-triazine-3-thione (Figure 1). In addition to structural, solvatochromic properties of the mentioned molecule are discussed.

Bottom Line: It was found that the monomer of the ligand 5-Methoxy-5,6-diphenyl-4,5-dihydro-2H-1,2,4-triazine-3-thione, further extends into 3D networks via hydrogen bonding and pi-pi stacking interactions.While progressing from the non-polar solvent to the polar one, the main intense band at 310 nm, which is due to the π-π* transition, was red shifted by 13 nm.Thus, the title compound showed positive solvatochromic behavior.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Chemistry, Lorestan University, Khorramabad, Iran.

ABSTRACT

Background: For the development of properties in molecular crystals, such as electrical conductivities, magnetic properties, or non-linear optical properties, not only the electronic properties of molecules themselves matter, but also the molecular arrangements in the crystals are very important. Therefore, the design of the crystal structures and the control of molecular arrangements have attracted much attention in recent years. Among various ligands, triazine moieties have been especially interesting because of their biological, pharmacological and medicinal properties.

Results: Crystal structure of 5-Methoxy-5,6-diphenyl-4,5-dihydro-2H-1,2,4-triazine-3-thione is Monoclinic, which consists of space group P21/c with a = 9.699(1), b = 8.500(1), c = 18.044(2) Å, β = 101.290(7)° and Z = 4, R1 = 0.0371 and wR2 = 0.1008 with 2456 reflections (I > 2σ(I)). Intermolecular H bonds between NH groups are acting as donors and S atoms as acceptors. There are also shorted face-to-face as well as edge to face π-π stacking interactions between the parallel aromatic rings. The behavior of solvatochromic of the mentioned compound that involved interhydrogen bonding was investigated by studying its electronic absorption spectra in pure organic solvents of different characters.

Conclusions: The crystal structure of C16H15N3OS, shows the expected face-to-face π-π stacking interactions between aromatic rings of the neighbor chains in this compound. The centroid-centroid distance between the aromatic rings is 3.325 Å. It was found that the monomer of the ligand 5-Methoxy-5,6-diphenyl-4,5-dihydro-2H-1,2,4-triazine-3-thione, further extends into 3D networks via hydrogen bonding and pi-pi stacking interactions. The solvatochromic behavior of the title compound was also investigated by studying its spectra in a selection of different organic solvents. While progressing from the non-polar solvent to the polar one, the main intense band at 310 nm, which is due to the π-π* transition, was red shifted by 13 nm. Thus, the title compound showed positive solvatochromic behavior.

No MeSH data available.


Related in: MedlinePlus