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Effects of uric acid on endothelial dysfunction in early chronic kidney disease and its mechanisms.

Wang Y, Bao X - Eur. J. Med. Res. (2013)

Bottom Line: An increase in serum uric acid (UA) occurs during the early and middle stages of chronic kidney disease (CKD) and aggravates the deterioration of kidney function.Linear regression analysis showed that the level of serum UA had a significant positive correlation with serum endothelin-1 and the percentage of collagen I positive area, but a negative correlation with serum nitric oxide (NO) and NO/endothelin-1 ratio.In addition, the level of serum UA had significant positive correlations with serum malonaldehyde, serum C-reactive protein, serum oxidatively-modified low-density lipoprotein and serum low-density lipoprotein, but a negative correlation with serum superoxide dismutase.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Nephrology, Jinshan Hospital affiliated to Fudan University, No,1508 Longhang Road, Jinshan District, Shanghai 201508, China.

ABSTRACT

Background: An increase in serum uric acid (UA) occurs during the early and middle stages of chronic kidney disease (CKD) and aggravates the deterioration of kidney function. This study aims to explore the relation between UA and endothelial dysfunction in early CKD and its mechanisms in a murine model.

Methods: The experimental animals were randomly divided into three groups (n = 10): sham-operation group (control group), right nephrectomy only group (CKD group) and right nephrectomy with oxonic potassium group (CKD with hyperuricemia group). Furthermore, we analyzed the relation between UA and endothelial dysfunction indices in early CKD as well as its mechanisms.

Results: Linear regression analysis showed that the level of serum UA had a significant positive correlation with serum endothelin-1 and the percentage of collagen I positive area, but a negative correlation with serum nitric oxide (NO) and NO/endothelin-1 ratio. In addition, the level of serum UA had significant positive correlations with serum malonaldehyde, serum C-reactive protein, serum oxidatively-modified low-density lipoprotein and serum low-density lipoprotein, but a negative correlation with serum superoxide dismutase.

Conclusions: Endothelial dysfunction in the CKD group was significant and had a positive correlation with the level of serum UA. Endothelial dysfunction in early CKD with hyperuricemia is perhaps related to oxidative stress, micro-inflammation and lipid oxidation.

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Collagen I staining of the vascular wall in groups A, B, and C. (A,B) A small amount of collagen I deposition was seen in the vascular wall of group A (×400). (C) Collagen I component was significantly increased in group C (×400).
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Figure 3: Collagen I staining of the vascular wall in groups A, B, and C. (A,B) A small amount of collagen I deposition was seen in the vascular wall of group A (×400). (C) Collagen I component was significantly increased in group C (×400).

Mentions: Collagen I staining of the vascular wall in the three groups is shown in Figure 3. Several collagen I depositions were visible in the vascular wall of groups A and B, while the collagen I component was significantly increased in group C. Statistical analysis showed that the percentage of collagen I positive area in the vessel wall of the experimental group was significantly higher than that of group A and group B (group C vs. group A, P < 0.01; group C vs. group B, P < 0.01) (Table 1).


Effects of uric acid on endothelial dysfunction in early chronic kidney disease and its mechanisms.

Wang Y, Bao X - Eur. J. Med. Res. (2013)

Collagen I staining of the vascular wall in groups A, B, and C. (A,B) A small amount of collagen I deposition was seen in the vascular wall of group A (×400). (C) Collagen I component was significantly increased in group C (×400).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3750429&req=5

Figure 3: Collagen I staining of the vascular wall in groups A, B, and C. (A,B) A small amount of collagen I deposition was seen in the vascular wall of group A (×400). (C) Collagen I component was significantly increased in group C (×400).
Mentions: Collagen I staining of the vascular wall in the three groups is shown in Figure 3. Several collagen I depositions were visible in the vascular wall of groups A and B, while the collagen I component was significantly increased in group C. Statistical analysis showed that the percentage of collagen I positive area in the vessel wall of the experimental group was significantly higher than that of group A and group B (group C vs. group A, P < 0.01; group C vs. group B, P < 0.01) (Table 1).

Bottom Line: An increase in serum uric acid (UA) occurs during the early and middle stages of chronic kidney disease (CKD) and aggravates the deterioration of kidney function.Linear regression analysis showed that the level of serum UA had a significant positive correlation with serum endothelin-1 and the percentage of collagen I positive area, but a negative correlation with serum nitric oxide (NO) and NO/endothelin-1 ratio.In addition, the level of serum UA had significant positive correlations with serum malonaldehyde, serum C-reactive protein, serum oxidatively-modified low-density lipoprotein and serum low-density lipoprotein, but a negative correlation with serum superoxide dismutase.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Nephrology, Jinshan Hospital affiliated to Fudan University, No,1508 Longhang Road, Jinshan District, Shanghai 201508, China.

ABSTRACT

Background: An increase in serum uric acid (UA) occurs during the early and middle stages of chronic kidney disease (CKD) and aggravates the deterioration of kidney function. This study aims to explore the relation between UA and endothelial dysfunction in early CKD and its mechanisms in a murine model.

Methods: The experimental animals were randomly divided into three groups (n = 10): sham-operation group (control group), right nephrectomy only group (CKD group) and right nephrectomy with oxonic potassium group (CKD with hyperuricemia group). Furthermore, we analyzed the relation between UA and endothelial dysfunction indices in early CKD as well as its mechanisms.

Results: Linear regression analysis showed that the level of serum UA had a significant positive correlation with serum endothelin-1 and the percentage of collagen I positive area, but a negative correlation with serum nitric oxide (NO) and NO/endothelin-1 ratio. In addition, the level of serum UA had significant positive correlations with serum malonaldehyde, serum C-reactive protein, serum oxidatively-modified low-density lipoprotein and serum low-density lipoprotein, but a negative correlation with serum superoxide dismutase.

Conclusions: Endothelial dysfunction in the CKD group was significant and had a positive correlation with the level of serum UA. Endothelial dysfunction in early CKD with hyperuricemia is perhaps related to oxidative stress, micro-inflammation and lipid oxidation.

Show MeSH
Related in: MedlinePlus