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Effects of MTHFR gene polymorphism on the clinical and electrophysiological characteristics of migraine.

Azimova JE, Sergeev AV, Korobeynikova LA, Kondratieva NS, Kokaeva ZG, Shaikhaev GO, Skorobogatykh KV, Fokina NM, Tabeeva GR, Klimov EA - BMC Neurol (2013)

Bottom Line: We have shown that MA was significantly more prevalent among the T-allele carriers (37.2%), as compared to the СС genotype patients (0%), р < 0.0001.Patients with TT genotype were not only more likely to have accompanying symptoms (significant differences were found only for photophobia), but also more sensitive to migraine attack triggers.In RP-VEP test results we observed a trend that the T-allele carriers were presented with the decreased N75/P100 amplitudes and a positive habituation index, as compared to the СС genotype patients.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Neurology and Clinical Neurophysiology, Scientific-Research Centre, Sechenov First Moscow State Medical University, Moscow, Russia. azimova.j@mail.ru

ABSTRACT

Background: It was previously shown that the MTHFR gene polymorphism correlated with an increased risk of migraine, particularly migraine with aura. The substitution of cytosine for thymine at the position 677 of the MTHFR gene leads to formation of the thermolabile form of the protein and development of hyperhomocysteinemia, which increases the probability of migraine. The purpose of this study was to determine whether the replacement of C677T in the gene MTHFR influenced any particular symptoms of the disease.

Methods: We have analyzed clinical and electrophysiological characteristics of 83 patients with migraine (migraine with aura (MA), 19 patients, and migraine without aura (MO), 64 patients, according to the ICHD-II (2003)) taking into account their genotypes of C677T variant of MTHFR.

Results: We have shown that MA was significantly more prevalent among the T-allele carriers (37.2%), as compared to the СС genotype patients (0%), р < 0.0001. Patients with TT genotype were not only more likely to have accompanying symptoms (significant differences were found only for photophobia), but also more sensitive to migraine attack triggers. In RP-VEP test results we observed a trend that the T-allele carriers were presented with the decreased N75/P100 amplitudes and a positive habituation index, as compared to the СС genotype patients.

Conclusions: Thus, according to our data, the MTHFR genotypes are associated with several clinical and electrophysiological characteristics of migraine.

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RP-VEP N75/P100 amplitude changes in the 3 genotype subgroups.
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Figure 3: RP-VEP N75/P100 amplitude changes in the 3 genotype subgroups.

Mentions: Analyzing the amplitude values of the five consecutive stimulus series, we observed the trend of decreasing N75-P100 amplitudes in the Т/Т group in all tests; the difference with the CC group (8.06 ± 1.3 and 8.66 ± 1.56, respectively) attained statistical significance in test blocks 4 (6.44 ± 1.3; p = 0.01) and 5 (6.16 ± 1.1; p = 0.008) (Figure 3, Table 3). No differences were seen in the N75/P100 amplitude between the СТ and the СС groups. However, there was observed a trend to a decrease of N75/P100 amplitude in the СТ group, as compared to the mutation-free patients (СС). Therefore, the patients suffering from migraine without aura and carrying the Т-allele (СТ and ТТ) presented with decreased RP-VEP N75/P100 amplitude levels in all test blocks, which were particularly apparent in the ТТ group.


Effects of MTHFR gene polymorphism on the clinical and electrophysiological characteristics of migraine.

Azimova JE, Sergeev AV, Korobeynikova LA, Kondratieva NS, Kokaeva ZG, Shaikhaev GO, Skorobogatykh KV, Fokina NM, Tabeeva GR, Klimov EA - BMC Neurol (2013)

RP-VEP N75/P100 amplitude changes in the 3 genotype subgroups.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3750291&req=5

Figure 3: RP-VEP N75/P100 amplitude changes in the 3 genotype subgroups.
Mentions: Analyzing the amplitude values of the five consecutive stimulus series, we observed the trend of decreasing N75-P100 amplitudes in the Т/Т group in all tests; the difference with the CC group (8.06 ± 1.3 and 8.66 ± 1.56, respectively) attained statistical significance in test blocks 4 (6.44 ± 1.3; p = 0.01) and 5 (6.16 ± 1.1; p = 0.008) (Figure 3, Table 3). No differences were seen in the N75/P100 amplitude between the СТ and the СС groups. However, there was observed a trend to a decrease of N75/P100 amplitude in the СТ group, as compared to the mutation-free patients (СС). Therefore, the patients suffering from migraine without aura and carrying the Т-allele (СТ and ТТ) presented with decreased RP-VEP N75/P100 amplitude levels in all test blocks, which were particularly apparent in the ТТ group.

Bottom Line: We have shown that MA was significantly more prevalent among the T-allele carriers (37.2%), as compared to the СС genotype patients (0%), р < 0.0001.Patients with TT genotype were not only more likely to have accompanying symptoms (significant differences were found only for photophobia), but also more sensitive to migraine attack triggers.In RP-VEP test results we observed a trend that the T-allele carriers were presented with the decreased N75/P100 amplitudes and a positive habituation index, as compared to the СС genotype patients.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Neurology and Clinical Neurophysiology, Scientific-Research Centre, Sechenov First Moscow State Medical University, Moscow, Russia. azimova.j@mail.ru

ABSTRACT

Background: It was previously shown that the MTHFR gene polymorphism correlated with an increased risk of migraine, particularly migraine with aura. The substitution of cytosine for thymine at the position 677 of the MTHFR gene leads to formation of the thermolabile form of the protein and development of hyperhomocysteinemia, which increases the probability of migraine. The purpose of this study was to determine whether the replacement of C677T in the gene MTHFR influenced any particular symptoms of the disease.

Methods: We have analyzed clinical and electrophysiological characteristics of 83 patients with migraine (migraine with aura (MA), 19 patients, and migraine without aura (MO), 64 patients, according to the ICHD-II (2003)) taking into account their genotypes of C677T variant of MTHFR.

Results: We have shown that MA was significantly more prevalent among the T-allele carriers (37.2%), as compared to the СС genotype patients (0%), р < 0.0001. Patients with TT genotype were not only more likely to have accompanying symptoms (significant differences were found only for photophobia), but also more sensitive to migraine attack triggers. In RP-VEP test results we observed a trend that the T-allele carriers were presented with the decreased N75/P100 amplitudes and a positive habituation index, as compared to the СС genotype patients.

Conclusions: Thus, according to our data, the MTHFR genotypes are associated with several clinical and electrophysiological characteristics of migraine.

Show MeSH
Related in: MedlinePlus