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Effects of MTHFR gene polymorphism on the clinical and electrophysiological characteristics of migraine.

Azimova JE, Sergeev AV, Korobeynikova LA, Kondratieva NS, Kokaeva ZG, Shaikhaev GO, Skorobogatykh KV, Fokina NM, Tabeeva GR, Klimov EA - BMC Neurol (2013)

Bottom Line: We have shown that MA was significantly more prevalent among the T-allele carriers (37.2%), as compared to the СС genotype patients (0%), р < 0.0001.Patients with TT genotype were not only more likely to have accompanying symptoms (significant differences were found only for photophobia), but also more sensitive to migraine attack triggers.In RP-VEP test results we observed a trend that the T-allele carriers were presented with the decreased N75/P100 amplitudes and a positive habituation index, as compared to the СС genotype patients.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Neurology and Clinical Neurophysiology, Scientific-Research Centre, Sechenov First Moscow State Medical University, Moscow, Russia. azimova.j@mail.ru

ABSTRACT

Background: It was previously shown that the MTHFR gene polymorphism correlated with an increased risk of migraine, particularly migraine with aura. The substitution of cytosine for thymine at the position 677 of the MTHFR gene leads to formation of the thermolabile form of the protein and development of hyperhomocysteinemia, which increases the probability of migraine. The purpose of this study was to determine whether the replacement of C677T in the gene MTHFR influenced any particular symptoms of the disease.

Methods: We have analyzed clinical and electrophysiological characteristics of 83 patients with migraine (migraine with aura (MA), 19 patients, and migraine without aura (MO), 64 patients, according to the ICHD-II (2003)) taking into account their genotypes of C677T variant of MTHFR.

Results: We have shown that MA was significantly more prevalent among the T-allele carriers (37.2%), as compared to the СС genotype patients (0%), р < 0.0001. Patients with TT genotype were not only more likely to have accompanying symptoms (significant differences were found only for photophobia), but also more sensitive to migraine attack triggers. In RP-VEP test results we observed a trend that the T-allele carriers were presented with the decreased N75/P100 amplitudes and a positive habituation index, as compared to the СС genotype patients.

Conclusions: Thus, according to our data, the MTHFR genotypes are associated with several clinical and electrophysiological characteristics of migraine.

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Related in: MedlinePlus

Occurrence of migraine accompanying symptoms in patients with different genotypes of MTHFR. * - p<0.05 CC vs TT, # - p<0.05 CT vs TT.
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Figure 1: Occurrence of migraine accompanying symptoms in patients with different genotypes of MTHFR. * - p<0.05 CC vs TT, # - p<0.05 CT vs TT.

Mentions: Notwithstanding the fact that patients with different genotypes did not significantly differ in the frequency or duration of migraine attacks, patients with the ТТ genotype had a higher occurrence of accompanying symptoms (Figure 1), although significant differences were obtained only for photophobia. Besides, patients with the ТТ genotype were significantly (100% of patients) more sensitive to migraine attack triggers (weather changes, irregular sleep, certain foods), as compared to СС genotype (63.6%, p=0.002) and СТ genotype (82.6%, р=0.04) patients.


Effects of MTHFR gene polymorphism on the clinical and electrophysiological characteristics of migraine.

Azimova JE, Sergeev AV, Korobeynikova LA, Kondratieva NS, Kokaeva ZG, Shaikhaev GO, Skorobogatykh KV, Fokina NM, Tabeeva GR, Klimov EA - BMC Neurol (2013)

Occurrence of migraine accompanying symptoms in patients with different genotypes of MTHFR. * - p<0.05 CC vs TT, # - p<0.05 CT vs TT.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3750291&req=5

Figure 1: Occurrence of migraine accompanying symptoms in patients with different genotypes of MTHFR. * - p<0.05 CC vs TT, # - p<0.05 CT vs TT.
Mentions: Notwithstanding the fact that patients with different genotypes did not significantly differ in the frequency or duration of migraine attacks, patients with the ТТ genotype had a higher occurrence of accompanying symptoms (Figure 1), although significant differences were obtained only for photophobia. Besides, patients with the ТТ genotype were significantly (100% of patients) more sensitive to migraine attack triggers (weather changes, irregular sleep, certain foods), as compared to СС genotype (63.6%, p=0.002) and СТ genotype (82.6%, р=0.04) patients.

Bottom Line: We have shown that MA was significantly more prevalent among the T-allele carriers (37.2%), as compared to the СС genotype patients (0%), р < 0.0001.Patients with TT genotype were not only more likely to have accompanying symptoms (significant differences were found only for photophobia), but also more sensitive to migraine attack triggers.In RP-VEP test results we observed a trend that the T-allele carriers were presented with the decreased N75/P100 amplitudes and a positive habituation index, as compared to the СС genotype patients.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Neurology and Clinical Neurophysiology, Scientific-Research Centre, Sechenov First Moscow State Medical University, Moscow, Russia. azimova.j@mail.ru

ABSTRACT

Background: It was previously shown that the MTHFR gene polymorphism correlated with an increased risk of migraine, particularly migraine with aura. The substitution of cytosine for thymine at the position 677 of the MTHFR gene leads to formation of the thermolabile form of the protein and development of hyperhomocysteinemia, which increases the probability of migraine. The purpose of this study was to determine whether the replacement of C677T in the gene MTHFR influenced any particular symptoms of the disease.

Methods: We have analyzed clinical and electrophysiological characteristics of 83 patients with migraine (migraine with aura (MA), 19 patients, and migraine without aura (MO), 64 patients, according to the ICHD-II (2003)) taking into account their genotypes of C677T variant of MTHFR.

Results: We have shown that MA was significantly more prevalent among the T-allele carriers (37.2%), as compared to the СС genotype patients (0%), р < 0.0001. Patients with TT genotype were not only more likely to have accompanying symptoms (significant differences were found only for photophobia), but also more sensitive to migraine attack triggers. In RP-VEP test results we observed a trend that the T-allele carriers were presented with the decreased N75/P100 amplitudes and a positive habituation index, as compared to the СС genotype patients.

Conclusions: Thus, according to our data, the MTHFR genotypes are associated with several clinical and electrophysiological characteristics of migraine.

Show MeSH
Related in: MedlinePlus