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Correlation among Streptococcus bovis, endocarditis and septicemia in a patient with advanced colon cancer: a case report.

Abeni C, Rota L, Ogliosi C, Bertocchi P, Centurini PB, Zaniboni A - J Med Case Rep (2013)

Bottom Line: One of the bacterial agents that has been found to be associated with colorectal cancer is Streptococcus bovis, with 13% of infective endocarditis cases caused by this pathogenic species.A recent study suggests that the majority of patients affected by colonic cancer have a Streptococcus bovis/gallolyticus colonization that becomes apparent as an overt infection only when immunosystem disorders or cardiac valve lesions occur.This correlation is important for involving more specialists in a correct and early diagnosis of this rare, but potentially fatal, complication.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Medical Oncology, Fondazione Poliambulanza, Via Bissolati 57, 25124, Brescia, Italy. chiara.abeni@poliambulanza.it.

ABSTRACT

Introduction: One of the bacterial agents that has been found to be associated with colorectal cancer is Streptococcus bovis, with 13% of infective endocarditis cases caused by this pathogenic species.

Case presentation: We describe the case of a 57-year-old Caucasian man with infiltrating and ulcerating metastatic adenocarcinoma of the sigmoid colon. The patient was receiving second-line chemotherapy treatment and, on the eighth day of the second cycle, he developed a grade IV pancytopenia. We diagnosed a severe sepsis with positive blood cultures for Streptococcus bovis/gallolyticus with a secondary endocarditis.

Conclusions: A recent study suggests that the majority of patients affected by colonic cancer have a Streptococcus bovis/gallolyticus colonization that becomes apparent as an overt infection only when immunosystem disorders or cardiac valve lesions occur. This correlation is important for involving more specialists in a correct and early diagnosis of this rare, but potentially fatal, complication.

No MeSH data available.


Related in: MedlinePlus

Endocardial vegetation stack on the right coronary cusp.
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Figure 1: Endocardial vegetation stack on the right coronary cusp.

Mentions: In the meantime, Streptococcus gallolyticus subsp gallolyticus was isolated in the blood cultures. Echocardiography showed a moderate aortic valve insufficiency due to an endocardial vegetation stack on the right coronary cusp (about 10mm in diameter) protruding in the outflow tract of the left ventricle (FigureĀ 1). A cerebrospinal fluid sample was not taken due to the very low platelet count (5000/mL on the second day after admission).


Correlation among Streptococcus bovis, endocarditis and septicemia in a patient with advanced colon cancer: a case report.

Abeni C, Rota L, Ogliosi C, Bertocchi P, Centurini PB, Zaniboni A - J Med Case Rep (2013)

Endocardial vegetation stack on the right coronary cusp.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3750266&req=5

Figure 1: Endocardial vegetation stack on the right coronary cusp.
Mentions: In the meantime, Streptococcus gallolyticus subsp gallolyticus was isolated in the blood cultures. Echocardiography showed a moderate aortic valve insufficiency due to an endocardial vegetation stack on the right coronary cusp (about 10mm in diameter) protruding in the outflow tract of the left ventricle (FigureĀ 1). A cerebrospinal fluid sample was not taken due to the very low platelet count (5000/mL on the second day after admission).

Bottom Line: One of the bacterial agents that has been found to be associated with colorectal cancer is Streptococcus bovis, with 13% of infective endocarditis cases caused by this pathogenic species.A recent study suggests that the majority of patients affected by colonic cancer have a Streptococcus bovis/gallolyticus colonization that becomes apparent as an overt infection only when immunosystem disorders or cardiac valve lesions occur.This correlation is important for involving more specialists in a correct and early diagnosis of this rare, but potentially fatal, complication.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Medical Oncology, Fondazione Poliambulanza, Via Bissolati 57, 25124, Brescia, Italy. chiara.abeni@poliambulanza.it.

ABSTRACT

Introduction: One of the bacterial agents that has been found to be associated with colorectal cancer is Streptococcus bovis, with 13% of infective endocarditis cases caused by this pathogenic species.

Case presentation: We describe the case of a 57-year-old Caucasian man with infiltrating and ulcerating metastatic adenocarcinoma of the sigmoid colon. The patient was receiving second-line chemotherapy treatment and, on the eighth day of the second cycle, he developed a grade IV pancytopenia. We diagnosed a severe sepsis with positive blood cultures for Streptococcus bovis/gallolyticus with a secondary endocarditis.

Conclusions: A recent study suggests that the majority of patients affected by colonic cancer have a Streptococcus bovis/gallolyticus colonization that becomes apparent as an overt infection only when immunosystem disorders or cardiac valve lesions occur. This correlation is important for involving more specialists in a correct and early diagnosis of this rare, but potentially fatal, complication.

No MeSH data available.


Related in: MedlinePlus