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Acute responsivity of the serotonergic system to S-citalopram and positive emotionality-the moderating role of the 5-HTTLPR.

Wielpuetz C, Kuepper Y, Grant P, Munk AJ, Hennig J - Front Hum Neurosci (2013)

Bottom Line: In a placebo-controlled double-blind and randomized cross-over neuroendocrine challenge design (n = 72 healthy males) we investigated the association of the central serotonergic responsivity, 5-HTTLPR-genotype as well as their combined effects on positive emotionality.The findings correspond to previous research demonstrating that the 5-HTTLPR is not only involved in the negative-emotional aspects of behavior and temperament, but is associated, moreover, with positive affectivity-supporting the assumption of its valence-neutrality.In addition, our data are in line with the idea of possible influences of the 5-HTTLPR-genotype on early neuronal development.

View Article: PubMed Central - PubMed

Affiliation: Personality Psychology and Individual Differences, Department of Psychology, Justus-Liebig-University Giessen Giessen, Germany.

ABSTRACT
According to the idea that the central serotonergic system has a modulatory function on behavior and personality in general, we aimed to highlight its association to habitual positive emotionality. In a placebo-controlled double-blind and randomized cross-over neuroendocrine challenge design (n = 72 healthy males) we investigated the association of the central serotonergic responsivity, 5-HTTLPR-genotype as well as their combined effects on positive emotionality. Regression analyses revealed an involvement of the serotonergic system in positive emotionality. There was, however, no direct association between positive emotionality and cortisol responses to S-citalopram; rather 5-HTTLPR-genotype showed an association (p < 0.05). That is, positive emotionality scores increased with the number of s-alleles carried by the individuals. Most notable was the moderating role of 5-HTTLPR-genotype (p < 0.05) on the association between acute serotonergic responsivity and positive emotionality. Indeed, this association was only found in ss-homozygotes, in which the acute responsivity of the serotonergic system additionally seems to contribute to the level of positive emotionality (r = 0.70, p < 0.05). The findings correspond to previous research demonstrating that the 5-HTTLPR is not only involved in the negative-emotional aspects of behavior and temperament, but is associated, moreover, with positive affectivity-supporting the assumption of its valence-neutrality. In addition, our data are in line with the idea of possible influences of the 5-HTTLPR-genotype on early neuronal development. They also indicate the need for further studies in order to clearly elucidate the role of the serotonergic system and its subcomponents in the regulation of positive emotionality.

No MeSH data available.


Related in: MedlinePlus

Mean cortisol levels for both placebo and S-citalopram conditions for samples 1–7. Error bars indicate the SEM. The area between the curves for S-citalopram and placebo for samples 3–7 (80–200 min after substance intake) is represented in the AUC-R. ANOVAs for repeated measures showed a significant interaction: substance × time point [F(2.1, 144.1) = 3.71, p = 0.023, Greenhouse–Geisser-adjusted]. This analysis was based on N = 67 participants, as one participant had a missing cortisol-sample for the second time point. (*p < 0.01, **p < 0.001, +p = 0.066).
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Figure 1: Mean cortisol levels for both placebo and S-citalopram conditions for samples 1–7. Error bars indicate the SEM. The area between the curves for S-citalopram and placebo for samples 3–7 (80–200 min after substance intake) is represented in the AUC-R. ANOVAs for repeated measures showed a significant interaction: substance × time point [F(2.1, 144.1) = 3.71, p = 0.023, Greenhouse–Geisser-adjusted]. This analysis was based on N = 67 participants, as one participant had a missing cortisol-sample for the second time point. (*p < 0.01, **p < 0.001, +p = 0.066).

Mentions: In order to have a single measure for the serotonergic responsivity, we calculated the placebo-corrected area under the response curve (AUC-R) for the cortisol response (Pruessner et al., 2003). A preliminary analysis of the cortisol responses showed significant differences between the cortisol responses under placebo and S-citalopram for samples 4–6 (ps ≤ 0.008) and a trend for sample 7 (p = 0.066). Therefore, areas under the curves (AUCs) were calculated for samples 3–7, using sample 3 as baseline. Finally, the placebo corrected AUC-R was determined by subtracting the AUC for placebo from the AUC for S-citalopram (Figure 1).


Acute responsivity of the serotonergic system to S-citalopram and positive emotionality-the moderating role of the 5-HTTLPR.

Wielpuetz C, Kuepper Y, Grant P, Munk AJ, Hennig J - Front Hum Neurosci (2013)

Mean cortisol levels for both placebo and S-citalopram conditions for samples 1–7. Error bars indicate the SEM. The area between the curves for S-citalopram and placebo for samples 3–7 (80–200 min after substance intake) is represented in the AUC-R. ANOVAs for repeated measures showed a significant interaction: substance × time point [F(2.1, 144.1) = 3.71, p = 0.023, Greenhouse–Geisser-adjusted]. This analysis was based on N = 67 participants, as one participant had a missing cortisol-sample for the second time point. (*p < 0.01, **p < 0.001, +p = 0.066).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3750213&req=5

Figure 1: Mean cortisol levels for both placebo and S-citalopram conditions for samples 1–7. Error bars indicate the SEM. The area between the curves for S-citalopram and placebo for samples 3–7 (80–200 min after substance intake) is represented in the AUC-R. ANOVAs for repeated measures showed a significant interaction: substance × time point [F(2.1, 144.1) = 3.71, p = 0.023, Greenhouse–Geisser-adjusted]. This analysis was based on N = 67 participants, as one participant had a missing cortisol-sample for the second time point. (*p < 0.01, **p < 0.001, +p = 0.066).
Mentions: In order to have a single measure for the serotonergic responsivity, we calculated the placebo-corrected area under the response curve (AUC-R) for the cortisol response (Pruessner et al., 2003). A preliminary analysis of the cortisol responses showed significant differences between the cortisol responses under placebo and S-citalopram for samples 4–6 (ps ≤ 0.008) and a trend for sample 7 (p = 0.066). Therefore, areas under the curves (AUCs) were calculated for samples 3–7, using sample 3 as baseline. Finally, the placebo corrected AUC-R was determined by subtracting the AUC for placebo from the AUC for S-citalopram (Figure 1).

Bottom Line: In a placebo-controlled double-blind and randomized cross-over neuroendocrine challenge design (n = 72 healthy males) we investigated the association of the central serotonergic responsivity, 5-HTTLPR-genotype as well as their combined effects on positive emotionality.The findings correspond to previous research demonstrating that the 5-HTTLPR is not only involved in the negative-emotional aspects of behavior and temperament, but is associated, moreover, with positive affectivity-supporting the assumption of its valence-neutrality.In addition, our data are in line with the idea of possible influences of the 5-HTTLPR-genotype on early neuronal development.

View Article: PubMed Central - PubMed

Affiliation: Personality Psychology and Individual Differences, Department of Psychology, Justus-Liebig-University Giessen Giessen, Germany.

ABSTRACT
According to the idea that the central serotonergic system has a modulatory function on behavior and personality in general, we aimed to highlight its association to habitual positive emotionality. In a placebo-controlled double-blind and randomized cross-over neuroendocrine challenge design (n = 72 healthy males) we investigated the association of the central serotonergic responsivity, 5-HTTLPR-genotype as well as their combined effects on positive emotionality. Regression analyses revealed an involvement of the serotonergic system in positive emotionality. There was, however, no direct association between positive emotionality and cortisol responses to S-citalopram; rather 5-HTTLPR-genotype showed an association (p < 0.05). That is, positive emotionality scores increased with the number of s-alleles carried by the individuals. Most notable was the moderating role of 5-HTTLPR-genotype (p < 0.05) on the association between acute serotonergic responsivity and positive emotionality. Indeed, this association was only found in ss-homozygotes, in which the acute responsivity of the serotonergic system additionally seems to contribute to the level of positive emotionality (r = 0.70, p < 0.05). The findings correspond to previous research demonstrating that the 5-HTTLPR is not only involved in the negative-emotional aspects of behavior and temperament, but is associated, moreover, with positive affectivity-supporting the assumption of its valence-neutrality. In addition, our data are in line with the idea of possible influences of the 5-HTTLPR-genotype on early neuronal development. They also indicate the need for further studies in order to clearly elucidate the role of the serotonergic system and its subcomponents in the regulation of positive emotionality.

No MeSH data available.


Related in: MedlinePlus