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Association of systemic collagen type IV formation with survival among patients undergoing hemodialysis.

Leeming DJ, Karsdal MA, Rasmussen LM, Scholze A, Tepel M - PLoS ONE (2013)

Bottom Line: Plasma P4NP_7S was analyzed using a specific enzyme-linked immunosorbent assay detecting the amino-terminal propeptide of type IV procollagen.Survival analysis showed an increased risk of death in the highest P4NP_7S category compared to the other categories (Chi square 6.903; P = 0.032).Median survival was only 105 days in the highest P4NP_7S category whereas it was 629 days in the medium category, and 905 days in the lowest category.

View Article: PubMed Central - PubMed

Affiliation: Nordic Bioscience, Herlev, Denmark.

ABSTRACT

Objective: The 7S domain of collagen type IV (P4NP_7S) assessed in plasma represents systemic collagen type IV formation. The objective of the study was to investigate the association of systemic collagen type IV formation with survival among patients undergoing hemodialysis.

Methods: We performed an observational cohort study of 371 hemodialysis patients. Plasma P4NP_7S was analyzed using a specific enzyme-linked immunosorbent assay detecting the amino-terminal propeptide of type IV procollagen. Association between categories of plasma P4NP_7S concentrations and survival was initially assessed by Kaplan-Meier analysis, then in an adjusted Cox model.

Results: For hemodialysis patients in the highest category of systemic collagen type IV formation, i.e. plasma P4NP_7S concentrations more than 775 pg/L, an increased risk for death was observed (highest P4NP_7S category vs all other categories, hazard ratio, 1.934; 95% confidence interval, 1.139 to 3.285). Survival analysis showed an increased risk of death in the highest P4NP_7S category compared to the other categories (Chi square 6.903; P = 0.032). Median survival was only 105 days in the highest P4NP_7S category whereas it was 629 days in the medium category, and 905 days in the lowest category. Multivariable-adjusted Cox regression showed increased odds for death with higher age and higher P4NP_7S categories. Systemic collagen type IV formation was associated with plasma concentrations of the collagen IV degradation product C4M (Spearman r = 0.764; P<0.0001) confirming extracellular matrix turnover.

Conclusion: Among hemodialysis patients elevated systemic collagen type IV formation suggesting accelerating systemic fibrosis was associated with increased risk of death.

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Association of 7S domain of collagen type IV (P4NP_7S) plasma concentrations with plasma concentrations of the collagen type IV degradation product C4M.
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pone-0071050-g003: Association of 7S domain of collagen type IV (P4NP_7S) plasma concentrations with plasma concentrations of the collagen type IV degradation product C4M.

Mentions: To assess extracellular matrix turnover in hemodialysis patients we also analyzed plasma concentrations of the collagen type IV degradation product C4M. We observed a significant association of P4NP_7S concentrations with C4M concentrations (Spearman r = 0.764; P<0.0001; Figure 3). Hemodialysis patients in the highest plasma P4NP_7S category had higher C4M concentrations (median, 180 pg/L; IQR, 147 to 218 pg/L) compared to the medium category (median, 90 pg/L; IQT 72 to 118 pg/L) and compared to the lowest category (median, 60 pg/L; IQR, 47 to 70 pg/L; P<0.0001). These findings suggest characteristic extracellular matrix turnover in hemodialysis patients.


Association of systemic collagen type IV formation with survival among patients undergoing hemodialysis.

Leeming DJ, Karsdal MA, Rasmussen LM, Scholze A, Tepel M - PLoS ONE (2013)

Association of 7S domain of collagen type IV (P4NP_7S) plasma concentrations with plasma concentrations of the collagen type IV degradation product C4M.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3750054&req=5

pone-0071050-g003: Association of 7S domain of collagen type IV (P4NP_7S) plasma concentrations with plasma concentrations of the collagen type IV degradation product C4M.
Mentions: To assess extracellular matrix turnover in hemodialysis patients we also analyzed plasma concentrations of the collagen type IV degradation product C4M. We observed a significant association of P4NP_7S concentrations with C4M concentrations (Spearman r = 0.764; P<0.0001; Figure 3). Hemodialysis patients in the highest plasma P4NP_7S category had higher C4M concentrations (median, 180 pg/L; IQR, 147 to 218 pg/L) compared to the medium category (median, 90 pg/L; IQT 72 to 118 pg/L) and compared to the lowest category (median, 60 pg/L; IQR, 47 to 70 pg/L; P<0.0001). These findings suggest characteristic extracellular matrix turnover in hemodialysis patients.

Bottom Line: Plasma P4NP_7S was analyzed using a specific enzyme-linked immunosorbent assay detecting the amino-terminal propeptide of type IV procollagen.Survival analysis showed an increased risk of death in the highest P4NP_7S category compared to the other categories (Chi square 6.903; P = 0.032).Median survival was only 105 days in the highest P4NP_7S category whereas it was 629 days in the medium category, and 905 days in the lowest category.

View Article: PubMed Central - PubMed

Affiliation: Nordic Bioscience, Herlev, Denmark.

ABSTRACT

Objective: The 7S domain of collagen type IV (P4NP_7S) assessed in plasma represents systemic collagen type IV formation. The objective of the study was to investigate the association of systemic collagen type IV formation with survival among patients undergoing hemodialysis.

Methods: We performed an observational cohort study of 371 hemodialysis patients. Plasma P4NP_7S was analyzed using a specific enzyme-linked immunosorbent assay detecting the amino-terminal propeptide of type IV procollagen. Association between categories of plasma P4NP_7S concentrations and survival was initially assessed by Kaplan-Meier analysis, then in an adjusted Cox model.

Results: For hemodialysis patients in the highest category of systemic collagen type IV formation, i.e. plasma P4NP_7S concentrations more than 775 pg/L, an increased risk for death was observed (highest P4NP_7S category vs all other categories, hazard ratio, 1.934; 95% confidence interval, 1.139 to 3.285). Survival analysis showed an increased risk of death in the highest P4NP_7S category compared to the other categories (Chi square 6.903; P = 0.032). Median survival was only 105 days in the highest P4NP_7S category whereas it was 629 days in the medium category, and 905 days in the lowest category. Multivariable-adjusted Cox regression showed increased odds for death with higher age and higher P4NP_7S categories. Systemic collagen type IV formation was associated with plasma concentrations of the collagen IV degradation product C4M (Spearman r = 0.764; P<0.0001) confirming extracellular matrix turnover.

Conclusion: Among hemodialysis patients elevated systemic collagen type IV formation suggesting accelerating systemic fibrosis was associated with increased risk of death.

Show MeSH
Related in: MedlinePlus