Limits...
Altered pattern of spontaneous brain activity in the patients with end-stage renal disease: a resting-state functional MRI study with regional homogeneity analysis.

Liang X, Wen J, Ni L, Zhong J, Qi R, Zhang LJ, Lu GM - PLoS ONE (2013)

Bottom Line: No significant correlations were found between any regional ReHo values and disease duration, dialysis duration and serum creatinine values in ESRD patients (all P>0.05, AlphaSim corrected).Diffused decreased ReHo values were found in both MNE and non-NE patients.The progressively decreased ReHo in the default mode network (DMN), frontal and parietal lobes might be trait-related in MNE.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, China ; School of Medical Imaging, Xuzhou Medical College, Xuzhou, China.

ABSTRACT

Purpose: To investigate the pattern of spontaneous neural activity in patients with end-stage renal disease (ESRD) with and without neurocognitive dysfunction using resting-state functional magnetic resonance imaging (rs-fMRI) with a regional homogeneity (ReHo) algorithm.

Materials and methods: rs-fMRI data were acquired in 36 ESRD patients (minimal nephro-encephalopathy [MNE], n = 19, 13 male, 37±12.07 years; non-nephro-encephalopathy [non-NE], n = 17, 11 male, 38±12.13 years) and 20 healthy controls (13 male, 7 female, 36±10.27 years). Neuropsychological (number connection test type A [NCT-A], digit symbol test [DST]) and laboratory tests were performed in all patients. The Kendall's coefficient of concordance (KCC) was used to measure the regional homogeneity for each subject. The regional homogeneity maps were compared using ANOVA tests among MNE, non-NE, and healthy control groups and post hoc t -tests between each pair in a voxel-wise way. A multiple regression analysis was performed to evaluate the relationships between ReHo index and NCT-A, DST scores, serum creatinine and urea levels, disease and dialysis duration.

Results: Compared with healthy controls, both MNE and non-NE patients showed decreased ReHo in the multiple areas of bilateral frontal, parietal and temporal lobes. Compared with the non-NE, MNE patients showed decreased ReHo in the right inferior parietal lobe (IPL), medial frontal cortex (MFC) and left precuneus (PCu). The NCT-A scores and serum urea levels of ESRD patients negatively correlated with ReHo values in the frontal and parietal lobes, while DST scores positively correlated with ReHo values in the bilateral PCC/precuneus, MFC and inferior parietal lobe (IPL) (all P<0.05, AlphaSim corrected). No significant correlations were found between any regional ReHo values and disease duration, dialysis duration and serum creatinine values in ESRD patients (all P>0.05, AlphaSim corrected).

Conclusion: Diffused decreased ReHo values were found in both MNE and non-NE patients. The progressively decreased ReHo in the default mode network (DMN), frontal and parietal lobes might be trait-related in MNE. The ReHo analysis may be potentially valuable for elucidating neurocognitive abnormalities of ESRD patients and detecting the development from non-NE to MNE.

Show MeSH

Related in: MedlinePlus

ReHo differences among MNE, non-NE, and healthy controls (P<0.05, AlphaSim corrected).Compared with the healthy controls, MNE patients show decreased ReHo in the bilateral SMA, ACC, PCC, MOG, right insula, cuneus, MFG, IPL, STG, PCu, and left PreCG, PoCG, and non-NE patients show decreased ReHo in the bilateral ACC, cuneus, precuneus, STG, PreCG, left PoCG, MOG and right MFG, and Compared with the non-NE patients, the MNE patients show decreased ReHo in the right IPL, MFG and left precuneus. MNE  =  minimal nephro-encephalopathy; non-NE  =  non-nephro-encephalopathy; ReHo  =  regional homogeneity; IPL  =  inferior parietal lobe; PCu  =  precuneus; ACC  =  anterior cingulate cortex; PCC  =  posterior cingulate cortex; SMA  =  supplementary motor area; PreCG  =  precentral gyrus; PoCG  =  postcentral gyrus; SFG  =  superior frontal gyrus; MFG  =  medial frontal gyrus; STG  =  superior temporal gyrus; MOG  =  medial occipital gyrus.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3750036&req=5

pone-0071507-g002: ReHo differences among MNE, non-NE, and healthy controls (P<0.05, AlphaSim corrected).Compared with the healthy controls, MNE patients show decreased ReHo in the bilateral SMA, ACC, PCC, MOG, right insula, cuneus, MFG, IPL, STG, PCu, and left PreCG, PoCG, and non-NE patients show decreased ReHo in the bilateral ACC, cuneus, precuneus, STG, PreCG, left PoCG, MOG and right MFG, and Compared with the non-NE patients, the MNE patients show decreased ReHo in the right IPL, MFG and left precuneus. MNE  =  minimal nephro-encephalopathy; non-NE  =  non-nephro-encephalopathy; ReHo  =  regional homogeneity; IPL  =  inferior parietal lobe; PCu  =  precuneus; ACC  =  anterior cingulate cortex; PCC  =  posterior cingulate cortex; SMA  =  supplementary motor area; PreCG  =  precentral gyrus; PoCG  =  postcentral gyrus; SFG  =  superior frontal gyrus; MFG  =  medial frontal gyrus; STG  =  superior temporal gyrus; MOG  =  medial occipital gyrus.

Mentions: Compared with the healthy control group, both MNE and non-NE patients showed significantly decreased regional homogeneity in the bilateral frontal, parietal and temporal lobes (Fig.2, Tables2 and 3). In addition, when comparing with the non-NE patients, MNE patients showed decreased regional homogeneity in the right inferior parietal lobe (IPL), medial frontal cortex (MFC) and left precuneus (PCu). (P<0.05, AlphaSim corrected) (Fig.2, Table4).


Altered pattern of spontaneous brain activity in the patients with end-stage renal disease: a resting-state functional MRI study with regional homogeneity analysis.

Liang X, Wen J, Ni L, Zhong J, Qi R, Zhang LJ, Lu GM - PLoS ONE (2013)

ReHo differences among MNE, non-NE, and healthy controls (P<0.05, AlphaSim corrected).Compared with the healthy controls, MNE patients show decreased ReHo in the bilateral SMA, ACC, PCC, MOG, right insula, cuneus, MFG, IPL, STG, PCu, and left PreCG, PoCG, and non-NE patients show decreased ReHo in the bilateral ACC, cuneus, precuneus, STG, PreCG, left PoCG, MOG and right MFG, and Compared with the non-NE patients, the MNE patients show decreased ReHo in the right IPL, MFG and left precuneus. MNE  =  minimal nephro-encephalopathy; non-NE  =  non-nephro-encephalopathy; ReHo  =  regional homogeneity; IPL  =  inferior parietal lobe; PCu  =  precuneus; ACC  =  anterior cingulate cortex; PCC  =  posterior cingulate cortex; SMA  =  supplementary motor area; PreCG  =  precentral gyrus; PoCG  =  postcentral gyrus; SFG  =  superior frontal gyrus; MFG  =  medial frontal gyrus; STG  =  superior temporal gyrus; MOG  =  medial occipital gyrus.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3750036&req=5

pone-0071507-g002: ReHo differences among MNE, non-NE, and healthy controls (P<0.05, AlphaSim corrected).Compared with the healthy controls, MNE patients show decreased ReHo in the bilateral SMA, ACC, PCC, MOG, right insula, cuneus, MFG, IPL, STG, PCu, and left PreCG, PoCG, and non-NE patients show decreased ReHo in the bilateral ACC, cuneus, precuneus, STG, PreCG, left PoCG, MOG and right MFG, and Compared with the non-NE patients, the MNE patients show decreased ReHo in the right IPL, MFG and left precuneus. MNE  =  minimal nephro-encephalopathy; non-NE  =  non-nephro-encephalopathy; ReHo  =  regional homogeneity; IPL  =  inferior parietal lobe; PCu  =  precuneus; ACC  =  anterior cingulate cortex; PCC  =  posterior cingulate cortex; SMA  =  supplementary motor area; PreCG  =  precentral gyrus; PoCG  =  postcentral gyrus; SFG  =  superior frontal gyrus; MFG  =  medial frontal gyrus; STG  =  superior temporal gyrus; MOG  =  medial occipital gyrus.
Mentions: Compared with the healthy control group, both MNE and non-NE patients showed significantly decreased regional homogeneity in the bilateral frontal, parietal and temporal lobes (Fig.2, Tables2 and 3). In addition, when comparing with the non-NE patients, MNE patients showed decreased regional homogeneity in the right inferior parietal lobe (IPL), medial frontal cortex (MFC) and left precuneus (PCu). (P<0.05, AlphaSim corrected) (Fig.2, Table4).

Bottom Line: No significant correlations were found between any regional ReHo values and disease duration, dialysis duration and serum creatinine values in ESRD patients (all P>0.05, AlphaSim corrected).Diffused decreased ReHo values were found in both MNE and non-NE patients.The progressively decreased ReHo in the default mode network (DMN), frontal and parietal lobes might be trait-related in MNE.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, China ; School of Medical Imaging, Xuzhou Medical College, Xuzhou, China.

ABSTRACT

Purpose: To investigate the pattern of spontaneous neural activity in patients with end-stage renal disease (ESRD) with and without neurocognitive dysfunction using resting-state functional magnetic resonance imaging (rs-fMRI) with a regional homogeneity (ReHo) algorithm.

Materials and methods: rs-fMRI data were acquired in 36 ESRD patients (minimal nephro-encephalopathy [MNE], n = 19, 13 male, 37±12.07 years; non-nephro-encephalopathy [non-NE], n = 17, 11 male, 38±12.13 years) and 20 healthy controls (13 male, 7 female, 36±10.27 years). Neuropsychological (number connection test type A [NCT-A], digit symbol test [DST]) and laboratory tests were performed in all patients. The Kendall's coefficient of concordance (KCC) was used to measure the regional homogeneity for each subject. The regional homogeneity maps were compared using ANOVA tests among MNE, non-NE, and healthy control groups and post hoc t -tests between each pair in a voxel-wise way. A multiple regression analysis was performed to evaluate the relationships between ReHo index and NCT-A, DST scores, serum creatinine and urea levels, disease and dialysis duration.

Results: Compared with healthy controls, both MNE and non-NE patients showed decreased ReHo in the multiple areas of bilateral frontal, parietal and temporal lobes. Compared with the non-NE, MNE patients showed decreased ReHo in the right inferior parietal lobe (IPL), medial frontal cortex (MFC) and left precuneus (PCu). The NCT-A scores and serum urea levels of ESRD patients negatively correlated with ReHo values in the frontal and parietal lobes, while DST scores positively correlated with ReHo values in the bilateral PCC/precuneus, MFC and inferior parietal lobe (IPL) (all P<0.05, AlphaSim corrected). No significant correlations were found between any regional ReHo values and disease duration, dialysis duration and serum creatinine values in ESRD patients (all P>0.05, AlphaSim corrected).

Conclusion: Diffused decreased ReHo values were found in both MNE and non-NE patients. The progressively decreased ReHo in the default mode network (DMN), frontal and parietal lobes might be trait-related in MNE. The ReHo analysis may be potentially valuable for elucidating neurocognitive abnormalities of ESRD patients and detecting the development from non-NE to MNE.

Show MeSH
Related in: MedlinePlus