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New non-linear color look-up table for visualization of brain fractional anisotropy based on normative measurements - principals and first clinical use.

Keller J, Rulseh AM, Komárek A, Latnerová I, Rusina R, Brožová H, Vymazal J - PLoS ONE (2013)

Bottom Line: Clinical use was demonstrated on 17 multiple system atrophy (MSA) patients compared to 13 patients with Parkinson disease (PD) and 17 healthy subjects.Four blinded radiologists classified subjects as MSA/non-MSA.The LUTs generated from 12 and 30 MPG were comparable and accentuate FA abnormalities.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Third Faculty of Medicine, Charles University in Prague, Prague, Czech Republic ; Department of Radiology, Na Homolce Hospital, Prague, Czech Republic.

ABSTRACT
Fractional anisotropy (FA) is the most commonly used quantitative measure of diffusion in the brain. Changes in FA have been reported in many neurological disorders, but the implementation of diffusion tensor imaging (DTI) in daily clinical practice remains challenging. We propose a novel color look-up table (LUT) based on normative data as a tool for screening FA changes. FA was calculated for 76 healthy volunteers using 12 motion-probing gradient directions (MPG), a subset of 59 subjects was additionally scanned using 30 MPG. Population means and 95% prediction intervals for FA in the corpus callosum, frontal gray matter, thalamus and basal ganglia were used to create the LUT. Unique colors were assigned to inflection points with continuous ramps between them. Clinical use was demonstrated on 17 multiple system atrophy (MSA) patients compared to 13 patients with Parkinson disease (PD) and 17 healthy subjects. Four blinded radiologists classified subjects as MSA/non-MSA. Using only the LUT, high sensitivity (80%) and specificity (84%) were achieved in differentiating MSA subjects from PD subjects and controls. The LUTs generated from 12 and 30 MPG were comparable and accentuate FA abnormalities.

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Possible application of the look-up table to fractional anisotropy imaging.a) Healthy volunteer data (60 year old male), b) A subject with multiple system atrophy (62 year old male). Decreased FA in the cerebellar peduncles is best appreciated in the rightmost image).
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pone-0071431-g006: Possible application of the look-up table to fractional anisotropy imaging.a) Healthy volunteer data (60 year old male), b) A subject with multiple system atrophy (62 year old male). Decreased FA in the cerebellar peduncles is best appreciated in the rightmost image).

Mentions: Using the same methodology, we additionally measured FA in the pyramidal tract and middle cerebellar peduncle. The pyramidal tract is a major white matter bundle connecting the primary motor cortex in the frontal lobe and peripheral neurons in the spinal cord. After the fibers coalesce from the frontal cortex, this structure becomes visible on the coronal view as a symmetric, yellow/red structure passing from the top lateral part of the image to the center (see the middle column of Figure 6). The pyramidal tract was selected using both cROI (FA = 0.76, PI 0.66–0.85) and freehand (FA = 0.73, PI 0.69–0.78) selections. In total (using all values), FA was 0.75 with PI 0.67–0.82. FA in freehand selection was lower than in cROI, but the overlap is significant.


New non-linear color look-up table for visualization of brain fractional anisotropy based on normative measurements - principals and first clinical use.

Keller J, Rulseh AM, Komárek A, Latnerová I, Rusina R, Brožová H, Vymazal J - PLoS ONE (2013)

Possible application of the look-up table to fractional anisotropy imaging.a) Healthy volunteer data (60 year old male), b) A subject with multiple system atrophy (62 year old male). Decreased FA in the cerebellar peduncles is best appreciated in the rightmost image).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3750032&req=5

pone-0071431-g006: Possible application of the look-up table to fractional anisotropy imaging.a) Healthy volunteer data (60 year old male), b) A subject with multiple system atrophy (62 year old male). Decreased FA in the cerebellar peduncles is best appreciated in the rightmost image).
Mentions: Using the same methodology, we additionally measured FA in the pyramidal tract and middle cerebellar peduncle. The pyramidal tract is a major white matter bundle connecting the primary motor cortex in the frontal lobe and peripheral neurons in the spinal cord. After the fibers coalesce from the frontal cortex, this structure becomes visible on the coronal view as a symmetric, yellow/red structure passing from the top lateral part of the image to the center (see the middle column of Figure 6). The pyramidal tract was selected using both cROI (FA = 0.76, PI 0.66–0.85) and freehand (FA = 0.73, PI 0.69–0.78) selections. In total (using all values), FA was 0.75 with PI 0.67–0.82. FA in freehand selection was lower than in cROI, but the overlap is significant.

Bottom Line: Clinical use was demonstrated on 17 multiple system atrophy (MSA) patients compared to 13 patients with Parkinson disease (PD) and 17 healthy subjects.Four blinded radiologists classified subjects as MSA/non-MSA.The LUTs generated from 12 and 30 MPG were comparable and accentuate FA abnormalities.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Third Faculty of Medicine, Charles University in Prague, Prague, Czech Republic ; Department of Radiology, Na Homolce Hospital, Prague, Czech Republic.

ABSTRACT
Fractional anisotropy (FA) is the most commonly used quantitative measure of diffusion in the brain. Changes in FA have been reported in many neurological disorders, but the implementation of diffusion tensor imaging (DTI) in daily clinical practice remains challenging. We propose a novel color look-up table (LUT) based on normative data as a tool for screening FA changes. FA was calculated for 76 healthy volunteers using 12 motion-probing gradient directions (MPG), a subset of 59 subjects was additionally scanned using 30 MPG. Population means and 95% prediction intervals for FA in the corpus callosum, frontal gray matter, thalamus and basal ganglia were used to create the LUT. Unique colors were assigned to inflection points with continuous ramps between them. Clinical use was demonstrated on 17 multiple system atrophy (MSA) patients compared to 13 patients with Parkinson disease (PD) and 17 healthy subjects. Four blinded radiologists classified subjects as MSA/non-MSA. Using only the LUT, high sensitivity (80%) and specificity (84%) were achieved in differentiating MSA subjects from PD subjects and controls. The LUTs generated from 12 and 30 MPG were comparable and accentuate FA abnormalities.

Show MeSH
Related in: MedlinePlus