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New non-linear color look-up table for visualization of brain fractional anisotropy based on normative measurements - principals and first clinical use.

Keller J, Rulseh AM, Komárek A, Latnerová I, Rusina R, Brožová H, Vymazal J - PLoS ONE (2013)

Bottom Line: Clinical use was demonstrated on 17 multiple system atrophy (MSA) patients compared to 13 patients with Parkinson disease (PD) and 17 healthy subjects.Four blinded radiologists classified subjects as MSA/non-MSA.The LUTs generated from 12 and 30 MPG were comparable and accentuate FA abnormalities.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Third Faculty of Medicine, Charles University in Prague, Prague, Czech Republic ; Department of Radiology, Na Homolce Hospital, Prague, Czech Republic.

ABSTRACT
Fractional anisotropy (FA) is the most commonly used quantitative measure of diffusion in the brain. Changes in FA have been reported in many neurological disorders, but the implementation of diffusion tensor imaging (DTI) in daily clinical practice remains challenging. We propose a novel color look-up table (LUT) based on normative data as a tool for screening FA changes. FA was calculated for 76 healthy volunteers using 12 motion-probing gradient directions (MPG), a subset of 59 subjects was additionally scanned using 30 MPG. Population means and 95% prediction intervals for FA in the corpus callosum, frontal gray matter, thalamus and basal ganglia were used to create the LUT. Unique colors were assigned to inflection points with continuous ramps between them. Clinical use was demonstrated on 17 multiple system atrophy (MSA) patients compared to 13 patients with Parkinson disease (PD) and 17 healthy subjects. Four blinded radiologists classified subjects as MSA/non-MSA. Using only the LUT, high sensitivity (80%) and specificity (84%) were achieved in differentiating MSA subjects from PD subjects and controls. The LUTs generated from 12 and 30 MPG were comparable and accentuate FA abnormalities.

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Related in: MedlinePlus

Fractional anisotropy in regional groups.W, whole scale; BG, basal ganglia; GM, gray matter; Ccf, freehand selection in the corpus callosum; Ccr, circular region of interest in the corpus callosum.
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pone-0071431-g003: Fractional anisotropy in regional groups.W, whole scale; BG, basal ganglia; GM, gray matter; Ccf, freehand selection in the corpus callosum; Ccr, circular region of interest in the corpus callosum.

Mentions: Results of descriptive statistics were used as inflection points, which were assigned unique colors, and continuous ramps were generated (see Figure 2) to create a color transition between them (see Figure 3). Based on these ramps, FA values were assigned unique colors.


New non-linear color look-up table for visualization of brain fractional anisotropy based on normative measurements - principals and first clinical use.

Keller J, Rulseh AM, Komárek A, Latnerová I, Rusina R, Brožová H, Vymazal J - PLoS ONE (2013)

Fractional anisotropy in regional groups.W, whole scale; BG, basal ganglia; GM, gray matter; Ccf, freehand selection in the corpus callosum; Ccr, circular region of interest in the corpus callosum.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3750032&req=5

pone-0071431-g003: Fractional anisotropy in regional groups.W, whole scale; BG, basal ganglia; GM, gray matter; Ccf, freehand selection in the corpus callosum; Ccr, circular region of interest in the corpus callosum.
Mentions: Results of descriptive statistics were used as inflection points, which were assigned unique colors, and continuous ramps were generated (see Figure 2) to create a color transition between them (see Figure 3). Based on these ramps, FA values were assigned unique colors.

Bottom Line: Clinical use was demonstrated on 17 multiple system atrophy (MSA) patients compared to 13 patients with Parkinson disease (PD) and 17 healthy subjects.Four blinded radiologists classified subjects as MSA/non-MSA.The LUTs generated from 12 and 30 MPG were comparable and accentuate FA abnormalities.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Third Faculty of Medicine, Charles University in Prague, Prague, Czech Republic ; Department of Radiology, Na Homolce Hospital, Prague, Czech Republic.

ABSTRACT
Fractional anisotropy (FA) is the most commonly used quantitative measure of diffusion in the brain. Changes in FA have been reported in many neurological disorders, but the implementation of diffusion tensor imaging (DTI) in daily clinical practice remains challenging. We propose a novel color look-up table (LUT) based on normative data as a tool for screening FA changes. FA was calculated for 76 healthy volunteers using 12 motion-probing gradient directions (MPG), a subset of 59 subjects was additionally scanned using 30 MPG. Population means and 95% prediction intervals for FA in the corpus callosum, frontal gray matter, thalamus and basal ganglia were used to create the LUT. Unique colors were assigned to inflection points with continuous ramps between them. Clinical use was demonstrated on 17 multiple system atrophy (MSA) patients compared to 13 patients with Parkinson disease (PD) and 17 healthy subjects. Four blinded radiologists classified subjects as MSA/non-MSA. Using only the LUT, high sensitivity (80%) and specificity (84%) were achieved in differentiating MSA subjects from PD subjects and controls. The LUTs generated from 12 and 30 MPG were comparable and accentuate FA abnormalities.

Show MeSH
Related in: MedlinePlus