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Inverse association between hepatitis B virus infection and fatty liver disease: a large-scale study in populations seeking for check-up.

Cheng YL, Wang YJ, Kao WY, Chen PH, Huo TI, Huang YH, Lan KH, Su CW, Chan WL, Lin HC, Lee FY, Wu JC - PLoS ONE (2013)

Bottom Line: Multivariate analysis showed that BMI, age, waist circumference, systolic blood pressure, fasting glucose, cholesterol, alanine aminotransferase (ALT) levels, and platelet counts were positively associated, while hepatitis B surface antigen (HBsAg) positivity was inversely associated with fatty liver, especially for subjects with BMI>22.4 kg/m(2) and age>50 years.Patients with HBV infection were inversely associated with fatty liver disease than the general population, especially in older and obese patients.Furthermore, metabolic factors and HBV infection were associated with elevated serum ALT levels in fatty liver disease.

View Article: PubMed Central - PubMed

Affiliation: Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

ABSTRACT

Background: Although many studies have attempted to clarify the association between hepatitis B virus (HBV) infection and fatty liver disease, no prior studies have emphasized the relationship of HBV and fatty liver regarding different demographics of age and body mass index (BMI).

Aim: To investigate the correlation of HBV and fatty liver in the different demographics of age and BMI.

Methods: We enrolled consecutive subjects who had received health check-up services at the Taipei Veterans General Hospital from 2002 to 2009 and ultrasonography was used to diagnose fatty liver according to the practice guidelines of the American Gastroenterological Association.

Results: Among the 33,439 subjects enrolled in this study, fatty liver was diagnosed in 43.9% of the population and 38.9% of patients with chronic HBV infection. Multivariate analysis showed that BMI, age, waist circumference, systolic blood pressure, fasting glucose, cholesterol, alanine aminotransferase (ALT) levels, and platelet counts were positively associated, while hepatitis B surface antigen (HBsAg) positivity was inversely associated with fatty liver, especially for subjects with BMI>22.4 kg/m(2) and age>50 years. On the contrary, HBV infection was positively correlated with the presence of elevated serum ALT levels in subjects with fatty liver disease regardless of their age and BMI.

Conclusions: Metabolic factors are important determinants for the prevalence of fatty liver. Patients with HBV infection were inversely associated with fatty liver disease than the general population, especially in older and obese patients. Furthermore, metabolic factors and HBV infection were associated with elevated serum ALT levels in fatty liver disease.

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Distribution of fatty liver disease stratified by HBV status and BMI.The prevalence rates of fatty liver in all subgroups are expressed as prevalence rate (standard error). For subjects with BMI ≦22.4 kg/m2, the prevalence rate of fatty liver between those with and without HBV infection were insignificant by multivariate analysis though the P value was 0.021 by univariate analysis. For subjects with BMI >22.4 kg/m2 in combination with HBV infections have a significant lower rate of fatty liver (52.3%) in compared to those with BMI >22.4 kg/m2 but without HBV infections (59.8%).
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pone-0072049-g003: Distribution of fatty liver disease stratified by HBV status and BMI.The prevalence rates of fatty liver in all subgroups are expressed as prevalence rate (standard error). For subjects with BMI ≦22.4 kg/m2, the prevalence rate of fatty liver between those with and without HBV infection were insignificant by multivariate analysis though the P value was 0.021 by univariate analysis. For subjects with BMI >22.4 kg/m2 in combination with HBV infections have a significant lower rate of fatty liver (52.3%) in compared to those with BMI >22.4 kg/m2 but without HBV infections (59.8%).

Mentions: For the whole subjects stratified by BMI, those with BMI ≦22.4 kg/m2 in combination with HBV infections have a lower rate of fatty liver (14.7%), comparing to those with BMI ≦22.4 kg/m2 and without HBV infections (17.2%). (Figure 3) However, the difference was not significant by multivariate analysis. (Table 4) On the contrary, subjects with BMI >22.4 kg/m2 in combination with HBV infections have a significant lower rate of fatty liver (52.3%) in compared to those with BMI >22.4 kg/m2 but without HBV infections (59.8%) both in univariate and multivariate analyses.


Inverse association between hepatitis B virus infection and fatty liver disease: a large-scale study in populations seeking for check-up.

Cheng YL, Wang YJ, Kao WY, Chen PH, Huo TI, Huang YH, Lan KH, Su CW, Chan WL, Lin HC, Lee FY, Wu JC - PLoS ONE (2013)

Distribution of fatty liver disease stratified by HBV status and BMI.The prevalence rates of fatty liver in all subgroups are expressed as prevalence rate (standard error). For subjects with BMI ≦22.4 kg/m2, the prevalence rate of fatty liver between those with and without HBV infection were insignificant by multivariate analysis though the P value was 0.021 by univariate analysis. For subjects with BMI >22.4 kg/m2 in combination with HBV infections have a significant lower rate of fatty liver (52.3%) in compared to those with BMI >22.4 kg/m2 but without HBV infections (59.8%).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3750031&req=5

pone-0072049-g003: Distribution of fatty liver disease stratified by HBV status and BMI.The prevalence rates of fatty liver in all subgroups are expressed as prevalence rate (standard error). For subjects with BMI ≦22.4 kg/m2, the prevalence rate of fatty liver between those with and without HBV infection were insignificant by multivariate analysis though the P value was 0.021 by univariate analysis. For subjects with BMI >22.4 kg/m2 in combination with HBV infections have a significant lower rate of fatty liver (52.3%) in compared to those with BMI >22.4 kg/m2 but without HBV infections (59.8%).
Mentions: For the whole subjects stratified by BMI, those with BMI ≦22.4 kg/m2 in combination with HBV infections have a lower rate of fatty liver (14.7%), comparing to those with BMI ≦22.4 kg/m2 and without HBV infections (17.2%). (Figure 3) However, the difference was not significant by multivariate analysis. (Table 4) On the contrary, subjects with BMI >22.4 kg/m2 in combination with HBV infections have a significant lower rate of fatty liver (52.3%) in compared to those with BMI >22.4 kg/m2 but without HBV infections (59.8%) both in univariate and multivariate analyses.

Bottom Line: Multivariate analysis showed that BMI, age, waist circumference, systolic blood pressure, fasting glucose, cholesterol, alanine aminotransferase (ALT) levels, and platelet counts were positively associated, while hepatitis B surface antigen (HBsAg) positivity was inversely associated with fatty liver, especially for subjects with BMI>22.4 kg/m(2) and age>50 years.Patients with HBV infection were inversely associated with fatty liver disease than the general population, especially in older and obese patients.Furthermore, metabolic factors and HBV infection were associated with elevated serum ALT levels in fatty liver disease.

View Article: PubMed Central - PubMed

Affiliation: Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

ABSTRACT

Background: Although many studies have attempted to clarify the association between hepatitis B virus (HBV) infection and fatty liver disease, no prior studies have emphasized the relationship of HBV and fatty liver regarding different demographics of age and body mass index (BMI).

Aim: To investigate the correlation of HBV and fatty liver in the different demographics of age and BMI.

Methods: We enrolled consecutive subjects who had received health check-up services at the Taipei Veterans General Hospital from 2002 to 2009 and ultrasonography was used to diagnose fatty liver according to the practice guidelines of the American Gastroenterological Association.

Results: Among the 33,439 subjects enrolled in this study, fatty liver was diagnosed in 43.9% of the population and 38.9% of patients with chronic HBV infection. Multivariate analysis showed that BMI, age, waist circumference, systolic blood pressure, fasting glucose, cholesterol, alanine aminotransferase (ALT) levels, and platelet counts were positively associated, while hepatitis B surface antigen (HBsAg) positivity was inversely associated with fatty liver, especially for subjects with BMI>22.4 kg/m(2) and age>50 years. On the contrary, HBV infection was positively correlated with the presence of elevated serum ALT levels in subjects with fatty liver disease regardless of their age and BMI.

Conclusions: Metabolic factors are important determinants for the prevalence of fatty liver. Patients with HBV infection were inversely associated with fatty liver disease than the general population, especially in older and obese patients. Furthermore, metabolic factors and HBV infection were associated with elevated serum ALT levels in fatty liver disease.

Show MeSH
Related in: MedlinePlus