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Factors other than the glomerular filtration rate that determine the serum beta-2-microglobulin level.

Stanga Z, Nock S, Medina-Escobar P, Nydegger UE, Risch M, Risch L - PLoS ONE (2013)

Bottom Line: As a marker of kidney function, the Berlin Initiative Study equation 2 for the estimation of the estimated glomerular filtration rate (eGFR(BIS2)) in the elderly was employed.In addition, there was an inverse non-renal relationship between systolic blood pressure, total cholesterol and current smoking status.Serum β2-microglobulin levels in elderly subjects are related to several non-renal factors.

View Article: PubMed Central - PubMed

Affiliation: Division of Endocrinology, Diabetes and Clinical Nutrition and Department of General Internal Medicine, University Hospital and University of Bern, Bern, Switzerland.

ABSTRACT

Background: β2-microglobulin has been increasingly investigated as a diagnostic marker of kidney function and a prognostic marker of adverse outcomes. To date, non-renal determinants of β2-microglobulin levels have not been well described. Non-renal determinants are important for the interpretation and appraisal of the diagnostic and prognostic value of any endogenous kidney function marker.

Methods: This cross-sectional analysis was performed within the framework of the www.seniorlabor.ch study, which includes subjectively healthy individuals aged ≥ 60 years. Factors known or suspected to have a non-renal association with kidney function markers were investigated for a non-renal association with serum β2-microglobulin. As a marker of kidney function, the Berlin Initiative Study equation 2 for the estimation of the estimated glomerular filtration rate (eGFR(BIS2)) in the elderly was employed.

Results: A total of 1302 participants (714 females and 588 males) were enrolled in the study. The use of a multivariate regression model adjusting for age, gender and kidney function (eGFR(BIS2)) revealed age, male gender, and C-reactive protein level to be positively associated with β2-microglobulin levels. In addition, there was an inverse non-renal relationship between systolic blood pressure, total cholesterol and current smoking status. No association with markers of diabetes mellitus, body stature, nutritional risk, thyroid function or calcium and phosphate levels was observed.

Conclusions: Serum β2-microglobulin levels in elderly subjects are related to several non-renal factors. These non-renal factors are not congruent to those known from other markers (i.e. cystatin C and creatinine) and remind of classical cardiovascular risk factors.

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Related in: MedlinePlus

The relationship between β2-microglobulin and eGFRBIS2.
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pone-0072073-g001: The relationship between β2-microglobulin and eGFRBIS2.

Mentions: A total of 1302 individuals (714 female/588 male) with a median age of 72 years and an IQR of (66,78) were included in the study. All participants were of Caucasian descent. The detailed characteristics of the study population are given in Table 1. The median eGFRBIS2 was 73 ml/min/1.73 m2 (62,83). An eGFRBIS2<60 ml/min/1.73 m2 was present in 20.20% of the participants, whereas an eGFRBIS2>90 ml/min/1.73 m2 was found in 9.83%. There were no significant gender-specific differences in age, systolic and diastolic blood pressure, eGFRBIS2, albumin, HbA1c, potassium or CRP. However, female participants had a significantly lower BMI, weight, height, GNRI score, smoking prevalence, cystatin C level, creatinine level, β2-microglobulin level, blood urea nitrogen level, hemoglobin level, fasting glucose level and WBC count. Males had lower calcium and phosphate levels than females. Although statistically significant, these gender-specific differences, with the exception of serum creatinine and hemoglobin levels, were small. The Spearman rank correlation coefficient of the reciprocal of β2-microglobulin and eGFRBIS2 was 0.70 (P<0.001). The relationship between the inverse β2-microglobulin levels and eGFRBIS2 is given in Figure 1. Table 2 shows the regression coefficients together with standard errors relating the log β2-microglobulin with different predictor variables. As expected, the univariate analysis of β2-microglobulin levels and the chosen predictors hypothesized to be associated with kidney function markers revealed a significant relationship for a majority of predictors.


Factors other than the glomerular filtration rate that determine the serum beta-2-microglobulin level.

Stanga Z, Nock S, Medina-Escobar P, Nydegger UE, Risch M, Risch L - PLoS ONE (2013)

The relationship between β2-microglobulin and eGFRBIS2.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3750024&req=5

pone-0072073-g001: The relationship between β2-microglobulin and eGFRBIS2.
Mentions: A total of 1302 individuals (714 female/588 male) with a median age of 72 years and an IQR of (66,78) were included in the study. All participants were of Caucasian descent. The detailed characteristics of the study population are given in Table 1. The median eGFRBIS2 was 73 ml/min/1.73 m2 (62,83). An eGFRBIS2<60 ml/min/1.73 m2 was present in 20.20% of the participants, whereas an eGFRBIS2>90 ml/min/1.73 m2 was found in 9.83%. There were no significant gender-specific differences in age, systolic and diastolic blood pressure, eGFRBIS2, albumin, HbA1c, potassium or CRP. However, female participants had a significantly lower BMI, weight, height, GNRI score, smoking prevalence, cystatin C level, creatinine level, β2-microglobulin level, blood urea nitrogen level, hemoglobin level, fasting glucose level and WBC count. Males had lower calcium and phosphate levels than females. Although statistically significant, these gender-specific differences, with the exception of serum creatinine and hemoglobin levels, were small. The Spearman rank correlation coefficient of the reciprocal of β2-microglobulin and eGFRBIS2 was 0.70 (P<0.001). The relationship between the inverse β2-microglobulin levels and eGFRBIS2 is given in Figure 1. Table 2 shows the regression coefficients together with standard errors relating the log β2-microglobulin with different predictor variables. As expected, the univariate analysis of β2-microglobulin levels and the chosen predictors hypothesized to be associated with kidney function markers revealed a significant relationship for a majority of predictors.

Bottom Line: As a marker of kidney function, the Berlin Initiative Study equation 2 for the estimation of the estimated glomerular filtration rate (eGFR(BIS2)) in the elderly was employed.In addition, there was an inverse non-renal relationship between systolic blood pressure, total cholesterol and current smoking status.Serum β2-microglobulin levels in elderly subjects are related to several non-renal factors.

View Article: PubMed Central - PubMed

Affiliation: Division of Endocrinology, Diabetes and Clinical Nutrition and Department of General Internal Medicine, University Hospital and University of Bern, Bern, Switzerland.

ABSTRACT

Background: β2-microglobulin has been increasingly investigated as a diagnostic marker of kidney function and a prognostic marker of adverse outcomes. To date, non-renal determinants of β2-microglobulin levels have not been well described. Non-renal determinants are important for the interpretation and appraisal of the diagnostic and prognostic value of any endogenous kidney function marker.

Methods: This cross-sectional analysis was performed within the framework of the www.seniorlabor.ch study, which includes subjectively healthy individuals aged ≥ 60 years. Factors known or suspected to have a non-renal association with kidney function markers were investigated for a non-renal association with serum β2-microglobulin. As a marker of kidney function, the Berlin Initiative Study equation 2 for the estimation of the estimated glomerular filtration rate (eGFR(BIS2)) in the elderly was employed.

Results: A total of 1302 participants (714 females and 588 males) were enrolled in the study. The use of a multivariate regression model adjusting for age, gender and kidney function (eGFR(BIS2)) revealed age, male gender, and C-reactive protein level to be positively associated with β2-microglobulin levels. In addition, there was an inverse non-renal relationship between systolic blood pressure, total cholesterol and current smoking status. No association with markers of diabetes mellitus, body stature, nutritional risk, thyroid function or calcium and phosphate levels was observed.

Conclusions: Serum β2-microglobulin levels in elderly subjects are related to several non-renal factors. These non-renal factors are not congruent to those known from other markers (i.e. cystatin C and creatinine) and remind of classical cardiovascular risk factors.

Show MeSH
Related in: MedlinePlus