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Enlargement of cerebral ventricles as an early indicator of encephalomyelitis.

Lepore S, Waiczies H, Hentschel J, Ji Y, Skodowski J, Pohlmann A, Millward JM, Paul F, Wuerfel J, Niendorf T, Waiczies S - PLoS ONE (2013)

Bottom Line: The increase in ventricle size was seen in the lateral, third and fourth ventricles.In parallel to this macroscopic phenomenon, we studied the temporal evolution of microscopic lesions commonly observed in the cerebellum also starting prior to disease onset.Our data suggest that changes in ventricle size during the early stages of brain inflammation could be an early indicator of the events preceding neurological disease and warrant further exploration in preclinical and clinical studies.

View Article: PubMed Central - PubMed

Affiliation: Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine, Berlin, Germany.

ABSTRACT
Inflammatory disorders of the central nervous system such as multiple sclerosis and acute disseminated encephalomyelitis involve an invasion of immune cells that ultimately leads to white matter demyelination, neurodegeneration and development of neurological symptoms. A clinical diagnosis is often made when neurodegenerative processes are already ongoing. In an attempt to seek early indicators of disease, we studied the temporal and spatial distribution of brain modifications in experimental autoimmune encephalomyelitis (EAE). In a thorough magnetic resonance imaging study performed with EAE mice, we observed significant enlargement of the ventricles prior to disease clinical manifestation and an increase in free water content within the cerebrospinal fluid as demonstrated by changes in T2 relaxation times. The increase in ventricle size was seen in the lateral, third and fourth ventricles. In some EAE mice the ventricle size started returning to normal values during disease remission. In parallel to this macroscopic phenomenon, we studied the temporal evolution of microscopic lesions commonly observed in the cerebellum also starting prior to disease onset. Our data suggest that changes in ventricle size during the early stages of brain inflammation could be an early indicator of the events preceding neurological disease and warrant further exploration in preclinical and clinical studies.

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Changes in volume for the single ventricular compartments.Shown is a graphical representation of the temporal changes in volume for both lateral (A), left lateral (B), right lateral (C), third (D) and fourth (E) ventricles for all EAE (n=20) and control (n=6) mice. All points represent a ratio of the daily ventricle volume to the ventricle volume prior to immunization (baseline d-15) and are synchronized to the day of clinical disease onset.
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pone-0072841-g004: Changes in volume for the single ventricular compartments.Shown is a graphical representation of the temporal changes in volume for both lateral (A), left lateral (B), right lateral (C), third (D) and fourth (E) ventricles for all EAE (n=20) and control (n=6) mice. All points represent a ratio of the daily ventricle volume to the ventricle volume prior to immunization (baseline d-15) and are synchronized to the day of clinical disease onset.

Mentions: To investigate the possibility that mechanical obstruction between the ventricles (e.g. due to lesion formation) could explain the changes in ventricular volume we calculated the size of each of all four ventricles independently and over time (Figure 4). All ventricles showed a volume increase before the symptom onset. However, the change in volume in the combined lateral ventricles (Figure 4A), left ventricle alone (Figure 4B) and right ventricle alone (Figure 4C) was much more pronounced than the change in volume in the third (Figure 4D) and fourth ventricle (Figure 4E).


Enlargement of cerebral ventricles as an early indicator of encephalomyelitis.

Lepore S, Waiczies H, Hentschel J, Ji Y, Skodowski J, Pohlmann A, Millward JM, Paul F, Wuerfel J, Niendorf T, Waiczies S - PLoS ONE (2013)

Changes in volume for the single ventricular compartments.Shown is a graphical representation of the temporal changes in volume for both lateral (A), left lateral (B), right lateral (C), third (D) and fourth (E) ventricles for all EAE (n=20) and control (n=6) mice. All points represent a ratio of the daily ventricle volume to the ventricle volume prior to immunization (baseline d-15) and are synchronized to the day of clinical disease onset.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3750011&req=5

pone-0072841-g004: Changes in volume for the single ventricular compartments.Shown is a graphical representation of the temporal changes in volume for both lateral (A), left lateral (B), right lateral (C), third (D) and fourth (E) ventricles for all EAE (n=20) and control (n=6) mice. All points represent a ratio of the daily ventricle volume to the ventricle volume prior to immunization (baseline d-15) and are synchronized to the day of clinical disease onset.
Mentions: To investigate the possibility that mechanical obstruction between the ventricles (e.g. due to lesion formation) could explain the changes in ventricular volume we calculated the size of each of all four ventricles independently and over time (Figure 4). All ventricles showed a volume increase before the symptom onset. However, the change in volume in the combined lateral ventricles (Figure 4A), left ventricle alone (Figure 4B) and right ventricle alone (Figure 4C) was much more pronounced than the change in volume in the third (Figure 4D) and fourth ventricle (Figure 4E).

Bottom Line: The increase in ventricle size was seen in the lateral, third and fourth ventricles.In parallel to this macroscopic phenomenon, we studied the temporal evolution of microscopic lesions commonly observed in the cerebellum also starting prior to disease onset.Our data suggest that changes in ventricle size during the early stages of brain inflammation could be an early indicator of the events preceding neurological disease and warrant further exploration in preclinical and clinical studies.

View Article: PubMed Central - PubMed

Affiliation: Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine, Berlin, Germany.

ABSTRACT
Inflammatory disorders of the central nervous system such as multiple sclerosis and acute disseminated encephalomyelitis involve an invasion of immune cells that ultimately leads to white matter demyelination, neurodegeneration and development of neurological symptoms. A clinical diagnosis is often made when neurodegenerative processes are already ongoing. In an attempt to seek early indicators of disease, we studied the temporal and spatial distribution of brain modifications in experimental autoimmune encephalomyelitis (EAE). In a thorough magnetic resonance imaging study performed with EAE mice, we observed significant enlargement of the ventricles prior to disease clinical manifestation and an increase in free water content within the cerebrospinal fluid as demonstrated by changes in T2 relaxation times. The increase in ventricle size was seen in the lateral, third and fourth ventricles. In some EAE mice the ventricle size started returning to normal values during disease remission. In parallel to this macroscopic phenomenon, we studied the temporal evolution of microscopic lesions commonly observed in the cerebellum also starting prior to disease onset. Our data suggest that changes in ventricle size during the early stages of brain inflammation could be an early indicator of the events preceding neurological disease and warrant further exploration in preclinical and clinical studies.

Show MeSH
Related in: MedlinePlus