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MNS16A tandem repeats minisatellite of human telomerase gene and cancer risk: a meta-analysis.

Xia X, Rui R, Quan S, Zhong R, Zou L, Lou J, Lu X, Ke J, Zhang T, Zhang Y, Liu L, Yan J, Miao X - PLoS ONE (2013)

Bottom Line: The cumulative analysis in chronologic order suggested a clear tendency towards a significant association with additional study samples.The results provided a more accurate depiction of the role of MNS16A in cerebral cancer and breast cancer susceptibility.Additional larger studies were warranted to validate our findings.

View Article: PubMed Central - PubMed

Affiliation: Clinical Laboratory of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.

ABSTRACT

Background: Researchers have provided evidence that telomere dysfunction play an important role in cancer development. MNS16A is a polymorphic tandem repeats minisatellite of human telomerase (hTERT) gene that influences promoter activity of hTERT and thus implicates to relate with risk of several malignancies. However, results on association between MNS16A and cancer risk remain controversial. We therefore conduct a meta-analysis to derive a more precise estimation of association between MNS16A and cancer risk.

Methods: A systematic literature search was conducted by searching PubMed, ISI Web of Knowledge, Human Genome and Epidemiology Network Navigator and Google Scholar digital database for publications on associations between MNS16A and cancer risk. Variants with statistically significant associations by meta-analysis were assessed using Venice criteria.

Results: 10 case-control articles enrolling 6101 cases and 10521 controls were brought into our meta-analysis. The relationships were strong epidemiological credibility in cerebral cancer and breast cancer population (P for heterogeneity > 0.1). The cumulative analysis in chronologic order suggested a clear tendency towards a significant association with additional study samples.

Conclusions: The results provided a more accurate depiction of the role of MNS16A in cerebral cancer and breast cancer susceptibility. Additional larger studies were warranted to validate our findings.

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Related in: MedlinePlus

Cumulative meta-analysis of association MNS16A with risk of cancer under dominant model.
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pone-0073367-g004: Cumulative meta-analysis of association MNS16A with risk of cancer under dominant model.

Mentions: Cumulative meta-analyses of MNS16A were conducted via an assortment of studies in chronologic order. Figure 4 shows the results from the cumulative meta-analyses in fixed-effects model. The effect of MNS16A tended to show a significant association over time in all genetic models. Moreover, the 95% CIs became increasingly narrow with increasing data, suggesting that the precision of the estimates was progressively boosted by continually adding more studies.


MNS16A tandem repeats minisatellite of human telomerase gene and cancer risk: a meta-analysis.

Xia X, Rui R, Quan S, Zhong R, Zou L, Lou J, Lu X, Ke J, Zhang T, Zhang Y, Liu L, Yan J, Miao X - PLoS ONE (2013)

Cumulative meta-analysis of association MNS16A with risk of cancer under dominant model.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3750000&req=5

pone-0073367-g004: Cumulative meta-analysis of association MNS16A with risk of cancer under dominant model.
Mentions: Cumulative meta-analyses of MNS16A were conducted via an assortment of studies in chronologic order. Figure 4 shows the results from the cumulative meta-analyses in fixed-effects model. The effect of MNS16A tended to show a significant association over time in all genetic models. Moreover, the 95% CIs became increasingly narrow with increasing data, suggesting that the precision of the estimates was progressively boosted by continually adding more studies.

Bottom Line: The cumulative analysis in chronologic order suggested a clear tendency towards a significant association with additional study samples.The results provided a more accurate depiction of the role of MNS16A in cerebral cancer and breast cancer susceptibility.Additional larger studies were warranted to validate our findings.

View Article: PubMed Central - PubMed

Affiliation: Clinical Laboratory of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.

ABSTRACT

Background: Researchers have provided evidence that telomere dysfunction play an important role in cancer development. MNS16A is a polymorphic tandem repeats minisatellite of human telomerase (hTERT) gene that influences promoter activity of hTERT and thus implicates to relate with risk of several malignancies. However, results on association between MNS16A and cancer risk remain controversial. We therefore conduct a meta-analysis to derive a more precise estimation of association between MNS16A and cancer risk.

Methods: A systematic literature search was conducted by searching PubMed, ISI Web of Knowledge, Human Genome and Epidemiology Network Navigator and Google Scholar digital database for publications on associations between MNS16A and cancer risk. Variants with statistically significant associations by meta-analysis were assessed using Venice criteria.

Results: 10 case-control articles enrolling 6101 cases and 10521 controls were brought into our meta-analysis. The relationships were strong epidemiological credibility in cerebral cancer and breast cancer population (P for heterogeneity > 0.1). The cumulative analysis in chronologic order suggested a clear tendency towards a significant association with additional study samples.

Conclusions: The results provided a more accurate depiction of the role of MNS16A in cerebral cancer and breast cancer susceptibility. Additional larger studies were warranted to validate our findings.

Show MeSH
Related in: MedlinePlus