Limits...
MNS16A tandem repeats minisatellite of human telomerase gene and cancer risk: a meta-analysis.

Xia X, Rui R, Quan S, Zhong R, Zou L, Lou J, Lu X, Ke J, Zhang T, Zhang Y, Liu L, Yan J, Miao X - PLoS ONE (2013)

Bottom Line: The cumulative analysis in chronologic order suggested a clear tendency towards a significant association with additional study samples.The results provided a more accurate depiction of the role of MNS16A in cerebral cancer and breast cancer susceptibility.Additional larger studies were warranted to validate our findings.

View Article: PubMed Central - PubMed

Affiliation: Clinical Laboratory of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.

ABSTRACT

Background: Researchers have provided evidence that telomere dysfunction play an important role in cancer development. MNS16A is a polymorphic tandem repeats minisatellite of human telomerase (hTERT) gene that influences promoter activity of hTERT and thus implicates to relate with risk of several malignancies. However, results on association between MNS16A and cancer risk remain controversial. We therefore conduct a meta-analysis to derive a more precise estimation of association between MNS16A and cancer risk.

Methods: A systematic literature search was conducted by searching PubMed, ISI Web of Knowledge, Human Genome and Epidemiology Network Navigator and Google Scholar digital database for publications on associations between MNS16A and cancer risk. Variants with statistically significant associations by meta-analysis were assessed using Venice criteria.

Results: 10 case-control articles enrolling 6101 cases and 10521 controls were brought into our meta-analysis. The relationships were strong epidemiological credibility in cerebral cancer and breast cancer population (P for heterogeneity > 0.1). The cumulative analysis in chronologic order suggested a clear tendency towards a significant association with additional study samples.

Conclusions: The results provided a more accurate depiction of the role of MNS16A in cerebral cancer and breast cancer susceptibility. Additional larger studies were warranted to validate our findings.

Show MeSH

Related in: MedlinePlus

Forest plot of MNS16A association with cancer risk under dominant model stratified by cancer type.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3750000&req=5

pone-0073367-g003: Forest plot of MNS16A association with cancer risk under dominant model stratified by cancer type.

Mentions: Then, we assessed the source of heterogeneity by cancer type (Table 3). On the basis of five cerebral cancer studies, there was no heterogeneity for all genetic models (P for heterogeneity > 0.1). Patients with MNS16A-S allele had a significant statistically association with cerebral cancer risk: with ORs of 1.42 (95%CI = 1.19–1.70), 1.22 (95%CI = 1.09–1.37), 1.32 (95%CI = 1.11–1.56) for SS versus LL genotype, dominant and recessive model (P for heterogeneity > 0.1). For breast cancer, patients carried with LS genotype had higher risk than SS genotype, which ORs and 95%CI were 1.52 (1.19–1.94) and 1.46 (1.16–1.84) for LS versus LL genotype and dominant models. However, no statistically significant associations were observed with lung cancer patients (Figure 3).


MNS16A tandem repeats minisatellite of human telomerase gene and cancer risk: a meta-analysis.

Xia X, Rui R, Quan S, Zhong R, Zou L, Lou J, Lu X, Ke J, Zhang T, Zhang Y, Liu L, Yan J, Miao X - PLoS ONE (2013)

Forest plot of MNS16A association with cancer risk under dominant model stratified by cancer type.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3750000&req=5

pone-0073367-g003: Forest plot of MNS16A association with cancer risk under dominant model stratified by cancer type.
Mentions: Then, we assessed the source of heterogeneity by cancer type (Table 3). On the basis of five cerebral cancer studies, there was no heterogeneity for all genetic models (P for heterogeneity > 0.1). Patients with MNS16A-S allele had a significant statistically association with cerebral cancer risk: with ORs of 1.42 (95%CI = 1.19–1.70), 1.22 (95%CI = 1.09–1.37), 1.32 (95%CI = 1.11–1.56) for SS versus LL genotype, dominant and recessive model (P for heterogeneity > 0.1). For breast cancer, patients carried with LS genotype had higher risk than SS genotype, which ORs and 95%CI were 1.52 (1.19–1.94) and 1.46 (1.16–1.84) for LS versus LL genotype and dominant models. However, no statistically significant associations were observed with lung cancer patients (Figure 3).

Bottom Line: The cumulative analysis in chronologic order suggested a clear tendency towards a significant association with additional study samples.The results provided a more accurate depiction of the role of MNS16A in cerebral cancer and breast cancer susceptibility.Additional larger studies were warranted to validate our findings.

View Article: PubMed Central - PubMed

Affiliation: Clinical Laboratory of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.

ABSTRACT

Background: Researchers have provided evidence that telomere dysfunction play an important role in cancer development. MNS16A is a polymorphic tandem repeats minisatellite of human telomerase (hTERT) gene that influences promoter activity of hTERT and thus implicates to relate with risk of several malignancies. However, results on association between MNS16A and cancer risk remain controversial. We therefore conduct a meta-analysis to derive a more precise estimation of association between MNS16A and cancer risk.

Methods: A systematic literature search was conducted by searching PubMed, ISI Web of Knowledge, Human Genome and Epidemiology Network Navigator and Google Scholar digital database for publications on associations between MNS16A and cancer risk. Variants with statistically significant associations by meta-analysis were assessed using Venice criteria.

Results: 10 case-control articles enrolling 6101 cases and 10521 controls were brought into our meta-analysis. The relationships were strong epidemiological credibility in cerebral cancer and breast cancer population (P for heterogeneity > 0.1). The cumulative analysis in chronologic order suggested a clear tendency towards a significant association with additional study samples.

Conclusions: The results provided a more accurate depiction of the role of MNS16A in cerebral cancer and breast cancer susceptibility. Additional larger studies were warranted to validate our findings.

Show MeSH
Related in: MedlinePlus