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MNS16A tandem repeats minisatellite of human telomerase gene and cancer risk: a meta-analysis.

Xia X, Rui R, Quan S, Zhong R, Zou L, Lou J, Lu X, Ke J, Zhang T, Zhang Y, Liu L, Yan J, Miao X - PLoS ONE (2013)

Bottom Line: The cumulative analysis in chronologic order suggested a clear tendency towards a significant association with additional study samples.The results provided a more accurate depiction of the role of MNS16A in cerebral cancer and breast cancer susceptibility.Additional larger studies were warranted to validate our findings.

View Article: PubMed Central - PubMed

Affiliation: Clinical Laboratory of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.

ABSTRACT

Background: Researchers have provided evidence that telomere dysfunction play an important role in cancer development. MNS16A is a polymorphic tandem repeats minisatellite of human telomerase (hTERT) gene that influences promoter activity of hTERT and thus implicates to relate with risk of several malignancies. However, results on association between MNS16A and cancer risk remain controversial. We therefore conduct a meta-analysis to derive a more precise estimation of association between MNS16A and cancer risk.

Methods: A systematic literature search was conducted by searching PubMed, ISI Web of Knowledge, Human Genome and Epidemiology Network Navigator and Google Scholar digital database for publications on associations between MNS16A and cancer risk. Variants with statistically significant associations by meta-analysis were assessed using Venice criteria.

Results: 10 case-control articles enrolling 6101 cases and 10521 controls were brought into our meta-analysis. The relationships were strong epidemiological credibility in cerebral cancer and breast cancer population (P for heterogeneity > 0.1). The cumulative analysis in chronologic order suggested a clear tendency towards a significant association with additional study samples.

Conclusions: The results provided a more accurate depiction of the role of MNS16A in cerebral cancer and breast cancer susceptibility. Additional larger studies were warranted to validate our findings.

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Related in: MedlinePlus

Forest plot of MNS16A association with cancer risk under dominant model stratified by ethnicity.
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pone-0073367-g002: Forest plot of MNS16A association with cancer risk under dominant model stratified by ethnicity.

Mentions: Stratified analysis was performed for two ethnicity groups in order to investigate the hypothesis of Asian and Caucasian genetic mechanisms in the development of MNS16A. (Table 3). No evidence of heterogeneity was revealed in Caucasian population (P for heterogeneity > 0.1), and all genetic models presented a significantly increased cancer risk, with ORs of 1.16 (95%CI = 1.05–1.28), 1.33 (95%CI = 1.15–1.54), 1.19 (95%CI = 1.09–1.31), and 1.23 (95%CI = 1.07–1.42) for LS versus LL genotype, SS versus LL genotype, dominant model, and recessive model, respectively. However, all genetic models presented no statistical differences of cancer risk among Asian population (Figure 2).


MNS16A tandem repeats minisatellite of human telomerase gene and cancer risk: a meta-analysis.

Xia X, Rui R, Quan S, Zhong R, Zou L, Lou J, Lu X, Ke J, Zhang T, Zhang Y, Liu L, Yan J, Miao X - PLoS ONE (2013)

Forest plot of MNS16A association with cancer risk under dominant model stratified by ethnicity.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3750000&req=5

pone-0073367-g002: Forest plot of MNS16A association with cancer risk under dominant model stratified by ethnicity.
Mentions: Stratified analysis was performed for two ethnicity groups in order to investigate the hypothesis of Asian and Caucasian genetic mechanisms in the development of MNS16A. (Table 3). No evidence of heterogeneity was revealed in Caucasian population (P for heterogeneity > 0.1), and all genetic models presented a significantly increased cancer risk, with ORs of 1.16 (95%CI = 1.05–1.28), 1.33 (95%CI = 1.15–1.54), 1.19 (95%CI = 1.09–1.31), and 1.23 (95%CI = 1.07–1.42) for LS versus LL genotype, SS versus LL genotype, dominant model, and recessive model, respectively. However, all genetic models presented no statistical differences of cancer risk among Asian population (Figure 2).

Bottom Line: The cumulative analysis in chronologic order suggested a clear tendency towards a significant association with additional study samples.The results provided a more accurate depiction of the role of MNS16A in cerebral cancer and breast cancer susceptibility.Additional larger studies were warranted to validate our findings.

View Article: PubMed Central - PubMed

Affiliation: Clinical Laboratory of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.

ABSTRACT

Background: Researchers have provided evidence that telomere dysfunction play an important role in cancer development. MNS16A is a polymorphic tandem repeats minisatellite of human telomerase (hTERT) gene that influences promoter activity of hTERT and thus implicates to relate with risk of several malignancies. However, results on association between MNS16A and cancer risk remain controversial. We therefore conduct a meta-analysis to derive a more precise estimation of association between MNS16A and cancer risk.

Methods: A systematic literature search was conducted by searching PubMed, ISI Web of Knowledge, Human Genome and Epidemiology Network Navigator and Google Scholar digital database for publications on associations between MNS16A and cancer risk. Variants with statistically significant associations by meta-analysis were assessed using Venice criteria.

Results: 10 case-control articles enrolling 6101 cases and 10521 controls were brought into our meta-analysis. The relationships were strong epidemiological credibility in cerebral cancer and breast cancer population (P for heterogeneity > 0.1). The cumulative analysis in chronologic order suggested a clear tendency towards a significant association with additional study samples.

Conclusions: The results provided a more accurate depiction of the role of MNS16A in cerebral cancer and breast cancer susceptibility. Additional larger studies were warranted to validate our findings.

Show MeSH
Related in: MedlinePlus